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Job Opportunities

Organization
Massachusetts General Hospital, Cardiovascular Research Center

Location
Boston, MA

Description
The projects involve the development of novel signal processing algorithms and hardware to improve health care delivery in:

  1. The Intensive Care Unit
  2. Smart-phone based diagnostics

The interested individual(s) will function as part of a multi-disciplinary team of life scientists, engineers and clinicians.

Environment
The mission of the laboratory is to develop advanced computational approaches to study the mechanisms of cardiac arrhythmias from the myocyte to the whole organ level. Massachusetts General Hospital (MGH) is a major research center, affiliated with Harvard Medical School and the Brigham and Women’s Hospital. Collectively, these institutions represent one of the largest aggregations of biomedical researchers in the world. Opportunities exist for scientific interaction and collaboration with an extensive program of seminars, symposia and other organized meetings focused on a large array of topics. These seminars are weekly and include local, national, and international speakers on topics of general relevance for cardiovascular science and medicine. The Cardiovascular Research Center (CVRC) has an internationally recognized research program in cardiovascular, vascular, and pulmonary disease and development. The CVRC is home to over 100 researchers, in two locations – the Charlestown Navy Yard and the new Richard B. Simches Research Building. The MGH Division of Cardiology and the CVRC have a proven track record in training leaders in the fields of applied cardiac electrophysiology, pulmonary and vascular biology.

Qualifications
The ideal candidate should have a Ph.D. in biomedical engineering or other relevant areas of biomedical sciences. She/he should possess excellent written and verbal communication skills, be independent, self- motivated, and should have solid knowledge of machine learning and signal processing, and significant programming experience in MATLAB and Python.

Contact
Antonis A. Armoundas, PhD
Massachusetts General Hospital/Cardiovascular Research Center 149 13th Street
Charlestown, MA 02129
TEL: 617-726-0930
FAX: 617-726-5806
Email: aarmoundas@partners.org

Organization
Massachusetts General Hospital, Cardiovascular Research Center

Location
Boston, MA

Description
A postdoctoral fellowship in pulmonary vascular biology is available in the Cardiovascular Research Center at Massachusetts General Hospital and Harvard Medical School in the laboratory of Dr. Paul Yu. A highly motivated candidate is sought for a fellowship that will examine cell signal transduction, cell biology, molecular pharmacology, and physiology with the goal of developing novel therapeutics for cardiopulmonary disease. Recent trainees have published high-profile manuscripts, presented at national conferences, won competitive fellowship and research awards, and contributed to the development of several treatments now in various stages of clinical development (Yung LM et al., Sci Transl Med 2020; Yang P et al., NEJM 2021). Recent trainees have attained faculty posts at prestigious academic institutions or attained Senior Scientist positions in the biotechnology and pharma industry. The Yu laboratory seeks to understand how signals mediated by the bone morphogenetic protein (BMP) and transforming growth factor-b (TGF-b) of molecules are transduced by target cells and integrated in physiologic and disease contexts. Human genetics has highlighted the roles of this signaling pathway in cardiopulmonary and musculoskeletal disease. We have developed unique experimental probes, novel animal and cellular models, and potentially translatable drug molecules to interrogate basic mechanisms of disease.  Our work lies at the nexus of progenitor cell biology, chemical biology, cardiovascular physiology, and experimental pharmacology.

We welcome applications from creative, independent, and entrepreneurial-minded individuals interested in pursuing multidisciplinary approaches to mechanisms of disease. A current CV, letter of interest, and three references should be sent to Dr. Paul Yu.

We are an Equal Opportunity Employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.

Organization
Massachusetts General Hospital, Cardiovascular Research Center

Location
Boston, MA

Description

The Cardiovascular Research Center (CVRC) in collaboration with the Center for the Neuroscience of Psychedelics (CNP) at Massachusetts General Hospital is seeking applicants for a two to three-year postdoctoral research fellowship under the supervision of Drs. Jeremy Ruskin and Leon Ptaszek commencing in mid to late 2022. The MGH CNP is an interdisciplinary center with senior scientific and clinical faculty representing diverse specialties including psychiatry, medicine, radiology, and neuroscience. The mission of the CNP is to collaboratively investigate the effects of current and future generations of psychedelics at the molecular, cellular and systems levels across different patient populations and in relevant experimental models. The goal of the CNP is to promote healing and alleviate patient suffering through the advancement of basic and clinical science.

Background and Objectives
Chronic stress states such as anxiety, depression, PTSD and substance use disorder contribute significantly to adverse cardiovascular risk factors and outcomes including elevated heart rates and blood pressure, diabetes, obesity, coronary artery and cerebrovascular disease, myocardial infarction, stroke and cardiac arrhythmias. Despite a growing body of research supporting the therapeutic benefits of psychedelic drugs, the mechanisms by which they may offer potential benefits in cardiovascular disease have not been explored. To address this gap, we propose to complement ongoing and planned clinical investigations in the MGH CNP by studying the downstream impact of psychedelic therapies for mental health conditions on biological markers of chronic stress and cardiovascular health. We propose to gather and analyze data on a range of cardiovascular risk factors (e.g. resting heart rate, heart rate variability, blood pressure, physical activity and BMI) obtained from short and long-term monitoring with current and newer generation wearable physiologic monitors, as well as plasma levels of inflammatory cytokines, lipids and glucose, prior to, during, and at regular intervals following psychedelic assisted therapy. Cardiovascular risk factors and outcomes will also be assessed during long term follow up. In addition, nonclinical studies on the autonomic, anti-inflammatory and cardiac electrophysiologic effects of first and second-generation psychedelics will be designed and carried out in experimental animal models.

Responsibilities and Goals

  • To develop research objectives, methods, projects and proposals
  • To plan, coordinate and conduct collaborative preclinical and clinical research projects
  • To evaluate research outcomes and prepare manuscripts for scientific presentation and publication
  • To participate in the formal educational and research activities of the MGH CNP and CVRC

Fellows will work under the close supervision of Drs. Ruskin and Ptaszek and in collaboration with senior faculty and research fellows in the MGH CNP.

Appointment: 2-3 years

Required Skills and Experience
Candidates with MD, PhD, or MD, PhD degrees with an interest in cardiovascular physiology, pharmacology and psychedelic research are invited to apply. Prior training and research experience in physiology, pharmacology and translational research are encouraged. Individuals must have good written and verbal communication skills and an ability to work as part of a team and collaborate with investigators from other disciplines. Interested candidates should contact Dr. Jeremy Ruskin and provide a CV, personal statement including research interests and experience, and the names of at least three individuals who will serve as references. The trainee will be selected based on scientific and scholarly promise, productivity, and commitment to a career in scientific research.

EOE Statement
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.

Organization
Massachusetts General Hospital, Cardiovascular Research Center

Location
Boston, MA

Description

The Integrated Vascular Biology and Imaging Laboratory which is located within the Cardiovascular Research Center (CVRC) of Massachusetts General Hospital is recruiting a Postdoctoral Fellow to study in vivo mechanisms of experimental venous and arterial disease.

Our laboratory operates at the interface of vascular biology and in vivo molecular, cellular, and structural imaging. The lab utilizes imaging to assess the role of inflammation in the evolution and complications of venous and arterial disease. We are a translational imaging and pharmacotherapeutics lab focusing on the diseases of atherosclerosis, venous thrombosis, and arteriovenous fistula failure. We are developing first-in-human strategies to image vascular inflammation at high-resolution using novel intravascular optical imaging devices.

Required Skills and Experience

  • We are recruiting a bright and enthusiastic postdoctoral research fellow to join our laboratory. The candidate (PhD, MD/PhD, or MD) should have experience in: 1) basic science of vascular biology related to thrombosis, atherosclerosis, or other vascular disease; and 2) in vivo mouse or large animal experience, ideally with surgical model creation and vascular assessment.
  • Additional desirable experience includes: 3) cell/molecular biology (cell culture, microscopy, protein and gene analysis, immunohistochemistry, immunofluorescence, flow cytometry) 4) in vivo vascular imaging experience – preclinical or clinical; 5) excellent oral and written communication skills, and 6) prior first-author publication record.

Support for this position is available via NIH funding. Collaboration among the CVRC faculty and fellows, and investigators throughout the MGH, Harvard Medical School and MIT communities, help to create a stimulating and productive research environment. We are committed to mentoring and guide research fellows to think creatively and independently, expand their experimental capabilities, and write impactful manuscripts and grants.

Start date will be immediate upon acceptance. Qualified and interested candidates should please send a CV, a brief summary of your research accomplishments (< ½ page), and names and contact information of three references by email to:

Farouc A. Jaffer, MD, PhD
MGH Cardiovascular Research Center
Integrated Vascular Biology and Imaging Laboratory
Simches Research Building, Room 3206
185 Cambridge St.
Boston, MA 02114

Jaffer Lab
PubMed Citations
Twitter: @faroucjaffer

Description

The laboratory of Dr. Anthony Rosenzweig at MGH is seeking a full-time Research Technician II to perform basic molecular biology and cell culture methods and small animal work. The lab studies the pathophysiology of heart disease with a growing focus on crosstalk between heart and brain. Our investigations focus on fundamental cellular processes such as cell growth, survival, and regeneration, as well as on the identification and validation of new therapeutic targets. Effects of genetic, pharmacological, and physiological (exercise, pregnancy) interventions are explored using high throughput profiling and screening techniques as well as mechanistic studies in mouse and cell culture models. We have identified a number of signaling pathways regulating the development of pathological and physiological cardiac phenotypes and are now uncovering roles for some of these pathways in neurocognitive function. Several promising therapeutic targets have come out of this work, including intracellular and intercellular signaling proteins, non-coding RNAs and transcriptional regulators. The selected candidate will join a group of talented and motivated basic and clinician scientists whose work has direct translational applications.

Principal Duties and Responsibilities

Lab duties will include cell culture, rodent work (genotyping, pharmacological, surgical interventions, and behavioral measurements etc.) and molecular biology/biochemical techniques such as qPCR and Western blot, DNA subcloning, CRISPR-based genome editing, viral vector construction, immunohistochemistry, histology, and enzyme assays, as well as data collection and analysis. The candidate will be expected to keep her/his work and data collection highly organized, and to help in the joint upkeep of the lab, as all lab members are assigned one or two lab jobs. As s/he gains more familiarity with the projects, s/he will take on responsibility for short- and long-term planning of experiments and will be expected to present data at lab meetings and research conferences. The candidate will also help orient and supervise more junior members joining the laboratory and to teach basic techniques.

Qualifications

The candidate should have a successful track record of reliability and collaboration. They should be excited about working on cardiovascular and neurological disease as well as the opportunity to learn and grow through this position. Individual initiative, self-motivation, and the ability to work both independently and collaboratively are all seen as important attributes of the successful candidate. S/he must be highly motivated to learn about cardiac physiology and neuroscience, and interested in applying powerful genetic, biochemical, animal models, and high throughput “-omic” strategies to advance understanding of cardiac illness, its relationship with cognitive dysfunction, and areas of therapeutic intervention.  S/he must be eager to read primary literature related to the basic science of cardiac/neurological health and disease. Some prior laboratory experience is desirable. Experience with rodent models, cell culture and molecular biology techniques, and familiarity with common computer programs (MS Office, Prism, etc), and biostatistical data analysis methods are preferred but not required.

Education

Bachelor’s degree required, preferably in a basic science discipline.

EEO Statement

Massachusetts General Hospital is an Equal Opportunity Employer.  By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.

Contact

Haobo Li, PhD
Haobo.Li@mgh.harvard.edu