Massachusetts General Hospital, Cardiovascular Research Center
The projects involve the development of novel signal processing algorithms and hardware to improve health care delivery in:
- The Intensive Care Unit
- Smart-phone based diagnostics
The interested individual(s) will function as part of a multi-disciplinary team of life scientists, engineers and clinicians.
The mission of the laboratory is to develop advanced computational approaches to study the mechanisms of cardiac arrhythmias from the myocyte to the whole organ level. Massachusetts General Hospital (MGH) is a major research center, affiliated with Harvard Medical School and the Brigham and Women’s Hospital. Collectively, these institutions represent one of the largest aggregations of biomedical researchers in the world. Opportunities exist for scientific interaction and collaboration with an extensive program of seminars, symposia and other organized meetings focused on a large array of topics. These seminars are weekly and include local, national, and international speakers on topics of general relevance for cardiovascular science and medicine. The Cardiovascular Research Center (CVRC) has an internationally recognized research program in cardiovascular, vascular, and pulmonary disease and development. The CVRC is home to over 100 researchers, in two locations – the Charlestown Navy Yard and the new Richard B. Simches Research Building. The MGH Division of Cardiology and the CVRC have a proven track record in training leaders in the fields of applied cardiac electrophysiology, pulmonary and vascular biology.
The ideal candidate should have a Ph.D. in biomedical engineering or other relevant areas of biomedical sciences. She/he should possess excellent written and verbal communication skills, be independent, self- motivated, and should have solid knowledge of machine learning and signal processing, and significant programming experience in MATLAB and Python.
Antonis A. Armoundas, PhD
Massachusetts General Hospital/Cardiovascular Research Center 149 13th Street
Charlestown, MA 02129
The laboratory of Dr. Anthony Rosenzweig at MGH is seeking a full-time Research Technician II to perform basic molecular biology and cell culture methods and small animal work. The lab studies the pathophysiology of heart disease with a growing focus on crosstalk between heart and brain. Our investigations focus on fundamental cellular processes such as cell growth, survival, and regeneration, as well as on the identification and validation of new therapeutic targets. Effects of genetic, pharmacological, and physiological (exercise, pregnancy) interventions are explored using high throughput profiling and screening techniques as well as mechanistic studies in mouse and cell culture models. We have identified a number of signaling pathways regulating the development of pathological and physiological cardiac phenotypes and are now uncovering roles for some of these pathways in neurocognitive function. Several promising therapeutic targets have come out of this work, including intracellular and intercellular signaling proteins, non-coding RNAs and transcriptional regulators. The selected candidate will join a group of talented and motivated basic and clinician scientists whose work has direct translational applications.
Principal Duties and Responsibilities
Lab duties will include cell culture, rodent work (genotyping, pharmacological, surgical interventions, and behavioral measurements etc.) and molecular biology/biochemical techniques such as qPCR and Western blot, DNA subcloning, CRISPR-based genome editing, viral vector construction, immunohistochemistry, histology, and enzyme assays, as well as data collection and analysis. The candidate will be expected to keep her/his work and data collection highly organized, and to help in the joint upkeep of the lab, as all lab members are assigned one or two lab jobs. As s/he gains more familiarity with the projects, s/he will take on responsibility for short- and long-term planning of experiments and will be expected to present data at lab meetings and research conferences. The candidate will also help orient and supervise more junior members joining the laboratory and to teach basic techniques.
The candidate should have a successful track record of reliability and collaboration. They should be excited about working on cardiovascular and neurological disease as well as the opportunity to learn and grow through this position. Individual initiative, self-motivation, and the ability to work both independently and collaboratively are all seen as important attributes of the successful candidate. S/he must be highly motivated to learn about cardiac physiology and neuroscience, and interested in applying powerful genetic, biochemical, animal models, and high throughput “-omic” strategies to advance understanding of cardiac illness, its relationship with cognitive dysfunction, and areas of therapeutic intervention. S/he must be eager to read primary literature related to the basic science of cardiac/neurological health and disease. Some prior laboratory experience is desirable. Experience with rodent models, cell culture and molecular biology techniques, and familiarity with common computer programs (MS Office, Prism, etc), and biostatistical data analysis methods are preferred but not required.
Bachelor’s degree required, preferably in a basic science discipline.
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
Haobo Li, PhD