Name: Invited Speaker Seminars
Start: 2025-06-24T16:00:00-04:00
End: 2025-06-24T17:00:00-04:00
Location: Hybrid – Zoom(https://partners.zoom.us/j/83437376110) and CVRC

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2024

Adenosine kinase inhibition protects mice from abdominal aortic aneurysm via epigenetic modulation of VSMC inflammation. Xu J, Liu Z, Yang Q, Ma Q, Zhou Y, Cai Y, Zhao D, Zhao G, Lu T, Ouyang K, Hong M, Kim HW, Shi H, Zhang J, Fulton D, Miller C, Malhotra R, Weintraub NL, Huo Y. Cardiovasc Res. 2024 Sep 2;120(10):1202-1217. PMID: 38722818. PMC11368124.
Obesity and age are transmission risk factors for SARS-CoV-2 infection among exposed individuals. Matamalas JT, Chelvanambi S, Decano JL, França RF, Halu A, Santinelli-Pestana DV, Aikawa E, Malhotra R, Aikawa M. PNAS Nexus. 2024 Aug 27;3(8):pgae294. PMID: 39192848. PMC11348562.
Percent Predicted Peak Exercise Oxygen Pulse Provides Insights Into Ventricular-Vascular Response and Prognosticates HFpEF. Li JP, Slocum C, Sbarbaro J, Schoenike M, Campain J, Prasad C, Nayor MG, Lewis GD, Malhotra R. JACC Adv. 2024 Jul 12;3(8):101101. PMID: 39105119. PMC11299572.
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes.
Kwak SH, Hernandez-Cancela RB, DiCorpo DA, Condon DE, Merino J, Wu P, Brody JA, Yao J, Guo X, Ahmadizar F, Meyer M, Sincan M, Mercader JM, Lee S, Haessler J, Vy HMT, Lin Z, Armstrong ND, Gu S, Tsao NL, Lange LA, Wang N, Wiggins KL, Trompet S, Liu S, Loos RJF, Judy R, Schroeder PH, Hasbani NR, Bos MM, Morrison AC, Jackson RD, Reiner AP, Manson JE, Chaudhary NS, Carmichael LK, Chen YI, Taylor KD, Ghanbari M, van Meurs J, Pitsillides AN, Psaty BM, Noordam R, Do R, Park KS, Jukema JW, Kavousi M, Correa A, Rich SS, Damrauer SM, Hajek C, Cho NH, Irvin MR, Pankow JS, Nadkarni GN, Sladek R, Goodarzi MO, Florez JC, Chasman DI, Heckbert SR, Kooperberg C, Dupuis J, Malhotra R, de Vries PS, Liu CT, Rotter JI, Meigs JB; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Diabetes Care. 2024 Jun 1;47(6):1042-1047. PMID: 38652672. PMC11116923.
Genetically proxied low-density lipoprotein cholesterol lowering via PCSK9-inhibitor drug targets and risk of congenital malformations. Ardissino M, Slob EAW, Reddy RK, Morley AP, Schuermans A, Hill P, Williamson C, Honigberg MC, de Marvao A, Ng FS. Eur J Prev Cardiol. 2024 Jun 3;31(8):955-965. PMID: 38294056. PMC11144467.
Cardiovascular Significance and Genetics of Epicardial and Pericardial Adiposity. Rämö JT, Kany S, Hou CR, Friedman SF, Roselli C, Nauffal V, Koyama S, Karjalainen J, Maddah M, Palotie A, Ellinor PT, Pirruccello JP; FinnGen. JAMA Cardiol. 2024 May 1;9(5):418-427.PMID: 38477908. PMC10938251.
Outcomes of peripheral artery disease and polyvascular disease in patients with end-stage kidney disease. Mehta H, Chan WC, Aday AW, Jones WS, Parmar GM, Hance K, Thors A, Alli A, Wiley M, Tadros P, Gupta K. J Vasc Surg. 2024 May;79(5):1170-1178.e10. PMID: 38244643.
Delays in Accessing Healthcare Across the Gender Spectrum in the All of Us Research Program. Finneran P, Toribio MP, Natarajan P, Honigberg MC. J Gen Intern Med. 2024 May;39(7):1156-1163. PMID: 38049655. PMC11116354.
Genetically Predicted Gestational Age and Birth Weight Are Associated With Cardiac and Pulmonary Vascular Remodeling in Adulthood. Schuermans A, Ardissino M, Nauffal V, Khurshid S, Pirruccello JP, Ellinor PT, Lewandowski AJ, Natarajan P, Honigberg MC. Eur J Prev Cardiol. 2024 May 11;31(7):e49-e52. PMID: 37694688. PMC10925550.
The Role of Genetics in Advancing Cardiometabolic Drug Development. Abou-Karam R, Cheng F, Gady S, Fahed AC. Curr Atheroscler Rep. 2024 May;26(5):153-162. PMID: 38451435. Review.
Cardiac contractility modulation in patients with heart failure – A review of the literature. Bazoukis G, Saplaouras A, Efthymiou P, Yiannikourides A, Liu T, Letsas KP, Efremidis M, Lampropoulos K, Xydonas S, Tse G, Armoundas AA. Heart Fail Rev. 2024 May;29(3):689-705. PMID: 38393423. Review.
Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis. Small AM, Melloni GEM, Kamanu FK, Bergmark BA, Bonaca MP, O’Donoghue ML, Giugliano RP, Scirica BM, Bhatt D, Antman EM, Raz I, Wiviott SD, Truong B, Wilson PWF, Cho K, O’Donnell CJ, Braunwald E, Lubitz SA, Ellinor P, Peloso GM, Ruff CT, Sabatine MS, Natarajan P, Marston NA. JAMA Cardiol. 2024 Apr 1;9(4):357-366. PMID: 38416462. PMC10902779.
Noninvasive Quantification of Radiation-Induced Lung Injury Using a Targeted Molecular Imaging Probe. Abston E, Zhou IY, Saenger JA, Shuvaev S, Akam E, Esfahani SA, Hariri LP, Rotile NJ, Crowley E, Montesi SB, Humblet V, Arabasz G, Khandekar M, Catana C, Fintelmann FJ, Caravan P, Lanuti M. Int J Radiat Oncol Biol Phys. 2024 Apr 1;118(5):1228-1239. PMID: 38072325. PMC11184492.
Keeping to the Rhythm of Cardiovascular Health. Kany S, Khurshid S. Eur J Prev Cardiol. 2024 Apr 18;31(6):655-657. PMID: 38159042. PMC11025035.
Sex Differences in the Association of Multiethnic Genome-Wide Blood Pressure Polygenic Risk Score With Population-Level Systolic Blood Pressure Trajectories. Shetty NS, Pampana A, Patel N, Yerabolu K, Patel G, Irvin MR, Natarajan P, Lin HJ, Guo X, Rich SS, Rotter JI, Li P, Arora G, Arora P. Circ Genom Precis Med. 2024 Apr;17(2):e004515. PMID: 38372177. PMC11021155.
Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation. Lin AE, Bapat AC, Xiao L, Niroula A, Ye J, Wong WJ, Agrawal M, Farady CJ, Boettcher A, Hergott CB, McConkey M, Flores-Bringas P, Shkolnik V, Bick AG, Milan D, Natarajan P, Libby P, Ellinor PT, Ebert BL. Circulation. 2024 Apr 30;149(18):1419-1434. PMID: 38357791. PMC11058018.
Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations. Small AM, Pournamdari A, Melloni GEM, Scirica BM, Bhatt DL, Raz I, Braunwald E, Giugliano RP, Sabatine MS, Peloso GM, Marston NA, Natarajan P. JAMA Cardiol. JAMA Cardiol. 2024 Apr 1;9(4):385-391. PMID: 38353970. PMC10867772.
CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis. Cheng H, Hua L, Tang H, Bao Z, Xu X, Zhu H, Wang S, Jiapaer Z, Bhatia R, Dunn IF, Deng J, Wang D, Sun S, Luan S, Ji J, Xie Q, Yang X, Lei J, Li G, Wang X, Gong Y. J Mol Cell Biol. 2024 Apr 4;15(10):mjad057. PMID: 37791390. PMC11195615.
Individual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis in the Women’s Health Initiative. Love SM, Collins JM, Anthony KM, Buchheit SF, Butler EN, Bey GS, Gondalia R, Hayden KM, Zannas AS, Bick AG, Manson JE, Desai PM, Natarajan P, Bhattacharya R, Jaiswal S, Barac A, Reiner A, Kooperberg C, Stewart JD, Whitsel EA. Womens Health Issues. 2024 Mar-Apr;34(2):197-207. PMID: 38061917. PMC10978295.
Unlocking the dark matter: noncoding RNAs and RNA modifications in cardiac aging. Kang J, Rhee J, Wang C, Yang Y, Li G, Li H. Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H832-H844. PMID: 38305752. PMC11221808 Review.
Comparative Analysis of Polymer Versus Non-Polymer Jacketed Wires in Chronic Total Occlusion Percutaneous Coronary Intervention. Alexandrou M, Rempakos A, Mutlu D, Ogaili AA, Choi JW, Poommipanit P, Alaswad K, Basir MB, Davies R, Benton S, Jaffer FA, Chandwaney RH, Kearney KE, ElGuindy AM, Rafeh NA, Goktekin O, Gorgulu S, Khatri JJ, Krestyaninov O, Khelimskii D, Rangan BV, Mastrodemos OC, Burke MN, Sandoval Y, Lombardi WL, Brilakis ES, Azzalini L. Am J Cardiol. 2024 Mar 15;215:10-18. PMID: 38224729.
Effect of Macitentan in Pulmonary Arterial Hypertension and the Relationship Between Echocardiography and cMRI Variables: REPAIR Echocardiography Sub-study Results. Torbicki A, Channick R, Galiè N, Kiely DG, Moceri P, Peacock A, Swift AJ, Tawakol A, Vonk Noordegraaf A, Flores D, Martin N, Rosenkranz S. Cardiol Ther. 2024 Mar;13(1):173-190. PMID: 38281309. PMC10899124.
MMCT-Loop: a mix model-based pipeline for calling targeted 3D chromatin loops. Tang L, Liao J, Hill MC, Hu J, Zhao Y, Ellinor PT, Li M. Nucleic Acids Res. 2024 Mar 21;52(5):e25. PMID: 38281134. PMC10954456.
Uncovering Unrecognized Heart Failure With Preserved Ejection Fraction Among Individuals With Obesity and Dyspnea. Kosyakovsky LB, Liu EE, Wang JK, Myers L, Parekh JK, Knauss H, Lewis GD, Malhotra R, Nayor M, Robbins JM, Gerszten RE, Hamburg NM, McNeill JN, Lau ES, Ho JE. Circ Heart Fail. 2024 May;17(5):e011366. PMID: 38742409. PMC11214582.
Clinical Utility of Infrapopliteal Calcium Score for the Evaluation of Severity of Peripheral Artery Disease. Lee S, Tanaka M, Patel S, Zacharias N, Hedgire S, Malhotra R, Dua A. J Vasc Interv Radiol. 2024 Mar;35(3):370-376.e2. PMID: 38043705. PMC11179150.
Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia. Schuermans A, Truong B, Ardissino M, Bhukar R, Slob EAW, Nakao T, Dron JS, Small AM, Cho SMJ, Yu Z, Hornsby W, Antoine T, Lannery K, Postupaka D, Gray KJ, Yan Q, Butterworth AS, Burgess S, Wood MJ, Scott NS, Harrington CM, Sarma AA, Lau ES, Roh JD, Januzzi JL Jr, Natarajan P, Honigberg MC. JAMA Cardiol. 2024 Mar 1;9(3):209-220. PMID: 38170504. PMC10765315.
Association of Somatic TET2 Mutations With Giant Cell Arteritis. Robinette ML, Weeks LD, Kramer RJ, Agrawal M, Gibson CJ, Yu Z, Sekar A, Mehta A, Niroula A, Brown JT, McDermott GC, Reshef ER, Lu JE, Liou VD, Chiou CA, Natarajan P, Freitag SK, Rao DA, Ebert BL. Arthritis Rheumatol. 2024 Mar;76(3):438-443. PMID: 37909388.
A Lifestyle Modification Program for Secondary Prevention of Atrial Fibrillation: Introductory Findings. Ashburner JM, Carmichael TD, Bhattacharya R, Natarajan P, Singer DE, Thorndike AN. J Cardiopulm Rehabil Prev. 2024 Mar 1;44(2):143-145. PMID: 38113350. PMC10863832.
Complex Genetic Architecture of Spontaneous Coronary Artery Dissection. Natarajan P, Day SM. JAMA Cardiol. 2024 Mar 1;9(3):262. PMID: 38265841.
PTSD increases risk for major adverse cardiovascular events through neural and cardio-inflammatory pathways. Seligowski AV, Grewal SS, Abohashem S, Zureigat H, Qamar I, Aldosoky W, Gharios C, Hanlon E, Alani O, Bollepalli SC, Armoundas A, Fayad ZA, Shin LM, Osborne MT, Tawakol A. Brain Behav Immun. 2024 Mar;117:149-154. PMID: 38218349. PMC10932910.
Convergence of coronary artery disease genes onto endothelial cell programs. Schnitzler GR, Kang H, Fang S, Angom RS, Lee-Kim VS, Ma XR, Zhou R, Zeng T, Guo K, Taylor MS, Vellarikkal SK, Barry AE, Sias-Garcia O, Bloemendal A, Munson G, Guckelberger P, Nguyen TH, Bergman DT, Hinshaw S, Cheng N, Cleary B, Aragam K, Lander ES, Finucane HK, Mukhopadhyay D, Gupta RM, Engreitz JM. Nature. 2024 Feb;626(8000):799-807. PMID: 38326615. PMC10921916.
Lack of leisure time physical activity and variations in cardiovascular mortality across US communities: a comprehensive county-level analysis (2011-2019). Abohashem S, Nasir K, Munir M, Sayed A, Aldosoky W, Abbasi T, Michos ED, Gulati M, Rana JS. Br J Sports Med. 2024 Feb 9;58(4):204-212. PMID: 38212043.
Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a. Armani-Tourret M, Gao C, Hartana CA, Sun W, Carrere L, Vela L, Hochroth A, Bellefroid M, Sbrolla A, Shea K, Flynn T, Roseto I, Rassadkina Y, Lee C, Giguel F, Malhotra R, Bushman FD, Gandhi RT, Yu XG, Kuritzkes DR, Lichterfeld M. Cell. 2024 Feb 29;187(5):1238-1254.e14. PMID: 38367616. PMC10903630.
Risk factors for clonal hematopoiesis of indeterminate potential in people with HIV: a report from the REPRIEVE trial. Bhattacharya R, Uddin MM, Patel AP, Niroula A, Finneran P, Bernardo R, Fitch KV, Lu MT, Bloomfield GS, Malvestutto C, Aberg JA, Fichtenbaum CJ, Hornsby W, Ribaudo HJ, Libby P, Ebert BL, Zanni MV, Douglas PS, Grinspoon SK, Natarajan P. Blood Adv. 2024 Feb 27;8(4):959-967. PMID: 38197863. PMC10877123.
Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias. Schuermans A, Vlasschaert C, Nauffal V, Cho SMJ, Uddin MM, Nakao T, Niroula A, Klarqvist MDR, Weeks LD, Lin AE, Saadatagah S, Lannery K, Wong M, Hornsby W, Lubitz SA, Ballantyne C, Jaiswal S, Libby P, Ebert BL, Bick AG, Ellinor PT, Natarajan P, Honigberg MC. Eur Heart J. 2024 Mar 7;45(10):791-805. PMID: 37952204. PMC10919923.
The impact of government policies, funding, and networking to accelerate transatlantic cardiovascular research. Acharya S, Das S, Devaux Y, Robinson EL. Eur Heart J. 2024 Feb 21;45(8):567-569. PMID: 38103179.
Trends of Lipid Concentrations, Awareness, Evaluation, and Treatment in Severe Dyslipidemia in US Adults. Shetty NS, Gaonkar M, Patel N, Knowles JW, Natarajan P, Arora G, Arora P. Mayo Clin Proc. 2024 Feb;99(2):271-282. PMID: 38189687. PMC10873035.
Comparison of cardiac magnetic resonance imaging, functional and haemodynamic variables in pulmonary arterial hypertension: insights from REPAIR. Kiely DG, Channick R, Flores D, Galiè N, MacDonald G, Marcus JT, Mitchell L, Peacock A, Rosenkranz S, Tawakol A, Torbicki A, Vonk Noordegraaf A, Swift AJ. ERJ Open Res. 2024 Feb 12;10(1):00547-2023. PMID: 38348238. PMC10860210.
Using Genomics to Identify Novel Therapeutic Targets for Aortic Disease. Raghavan A, Pirruccello JP, Ellinor PT, Lindsay ME. Arterioscler Thromb Vasc Biol. 2024 Feb;44(2):334-351. PMID: 38095107. PMC10843699. Review.
Using Genomics to Identify Novel Therapeutic Targets for Aortic Disease. Raghavan A, Pirruccello JP, Ellinor PT, Lindsay ME. Arterioscler Thromb Vasc Biol. 2024 Feb;44(2):334-351. PMID: 38095107. PMC10843699. Review.
Roles of Activin A and Gpnmb in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Liu H, Yerevanian A, Westerhoff M, Hastings MH, Guerra JRB, Zhao M, Svensson KJ, Cai B, Soukas AA, Rosenzweig A. Diabetes. 2024 Feb 1;73(2):260-279. PMID: 37934943. PMC10796305.
Cumulative Diastolic Blood Pressure Burden in Normal Systolic Blood Pressure and Cardiovascular Disease. Cho SMJ, Lee H, Koyama S, Zou RS, Schuermans A, Ganesh S, Hornsby W, Honigberg MC, Natarajan P. Hypertension. 2024 Feb;81(2):273-281. PMID: 38084606. PMC10841692.
A disease of her own? Unique features of heart failure in women. Spacht WA, Lau ES. Climacteric. 2024 Feb;27(1):32-40. PMID: 37768321. PMC10843094. Review.
Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association. Ardissino M, Morley AP, Slob EAW, Schuermans A, Rayes B, Raisi-Estabragh Z, de Marvao A, Burgess S, Rogne T, Honigberg MC, Ng FS. Eur Heart J. 2024 Feb 7;45(6):443-454. PMID: 37738114. PMC10849320.
HIPK1: a New Druggable Kinase Target for Treating Pathological Cardiac Hypertrophy. Spanos M, Gokulnath P, Chatterjee E, Varrias D, Sun L, Das S, Li G. J Cardiovasc Transl Res. 2024 Feb;17(1):230-232. PMID: 37326697.
Comparison of cardiac magnetic resonance imaging, functional and haemodynamic variables in pulmonary arterial hypertension: insights from REPAIR. Kiely DG, Channick R, Flores D, Galiè N, MacDonald G, Marcus JT, Mitchell L, Peacock A, Rosenkranz S, Tawakol A, Torbicki A, Vonk Noordegraaf A, Swift AJ. ERJ Open Res. 2024 Feb 12;10(1):00547-2023. PMID: 38348238. PMC10860210.
Radon Exposure, Clonal Hematopoiesis, and Stroke Susceptibility in the Women’s Health Initiative. Anthony KM, Collins JM, Love SM, Stewart JD, Buchheit SF, Gondalia R, Schwartz GG, Huang DY, Meliker JR, Zhang Z, Barac A, Desai P, Hayden KM, Honigberg MC, Jaiswal S, Natarajan P, Bick AG, Kooperberg C, Manson JE, Reiner AP, Whitsel EA. Neurology. 2024 Jan 23;102(2):e208055. PMID: 38170948. PMC10870742.
Per-Particle Cardiovascular Risk of Lipoprotein(a) vs Non-Lp(a) Apolipoprotein B-Containing Lipoproteins. Marston NA, Melloni GEM, Murphy SA, Morze J, Kamanu FK, Ellinor PT, Ruff CT, Sabatine MS. J Am Coll Cardiol. 2024 Jan 23;83(3):470-472. PMID: 38233021.
Clonal Hematopoiesis Risk Score and All-Cause and Cardiovascular Mortality in Older Adults. Saadatagah S, Uddin MM, Weeks LD, Niroula A, Ru M, Takahashi K, Gondek L, Yu B, Bick AG, Ebert BL, Platz EA, Natarajan P, Ballantyne CM. JAMA Netw Open. 2024 Jan 2;7(1):e2351927. PMID: 38231513. PMC10794939.
Systemic Arterial Oxygen Levels Differentiate Pre- and Post-capillary Predominant Hemodynamic Abnormalities During Exercise in Undifferentiated Dyspnea on Exertion. Hardin KM, Giverts I, Campain J, Farrell R, Cunningham T, Brooks L, Christ A, Wooster L, Bailey CS, Schoenike M, Sbarbaro J, Baggish A, Nayor M, Ho JE, Malhotra R, Shah R, Lewis GD. J Card Fail. 2024 Jan;30(1):39-47. PMID: 37467924.
DeepFreeze 3D-biofabrication for Bioengineering and Storage of Stem Cells in Thick and Large-Scale Human Tissue Analogs. Kumar A, Brown RA, Roufaeil DB, Gupta A, Lipford EL, Muthusamy D, Zalzman A, Hertzano R, Lowe T, Stains JP, Zalzman M. Adv Sci (Weinh). 2024 Jan 6:e2306683. PMID: 38183347. PMC10953591.
SGLT2 Inhibitors in Patients With Cancer Therapy-Related Cardiotoxicity: An Unexpected Benefit? Oren O, Natarajan P, Bhatt DL. JACC Heart Fail. 2024 Jan;12(1):79-82. PMID: 37999662.
Characteristics and Attitudes of Wearable Device Users and Nonusers in a Large Health Care System. Venn RA, Khurshid S, Grayson M, Ashburner JM, Al-Alusi MA, Chang Y, Foulkes A, Ellinor PT, McManus DD, Singer DE, Atlas SJ, Lubitz SA. J Am Heart Assoc. 2024 Jan 2;13(1):e032126. PMID: 38156452. PMC10863832.
Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health. Zekavat SM, Jorshery SD, Rauscher FG, Horn K, Sekimitsu S, Koyama S, Nguyen TT, Costanzo MC, Jang D, Burtt NP, Kühnapfel A, Shweikh Y, Ye Y, Raghu V, Zhao H, Ghassemi M, Elze T, Segrè AV, Wiggs JL, Del Priore L, Scholz M, Wang JC, Natarajan P, Zebardast N. Sci Transl Med. 2024 Jan 24;16(731):eadg4517. PMID: 38266105.
Mendelian Randomization and Cardiovascular Disease-Enabling Expert Readership. Natarajan P, Yancy CW. JAMA Cardiol. 2024 Jan 1;9(1):89-90. PMID: 37938849.
Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas. Hughes O, Bentley AR, Breeze CE, Aguet F, Xu X, Nadkarni G, Sun Q, Lin BM, Gilliland T, Meyer MC, Du J, Raffield LM, Kramer H, Morton RW, Gouveia MH, Atkinson EG, Valladares-Salgado A, Wacher-Rodarte N, Dueker ND, Guo X, Hai Y, Adeyemo A, Best LG, Cai J, Chen G, Chong M, Doumatey A, Eales J, Goodarzi MO, Ipp E, Irvin MR, Jiang M, Jones AC, Kooperberg C, Krieger JE, Lange EM, Lanktree MB, Lash JP, Lotufo PA, Loos RJF, Ha My VT, Peralta-Romero J, Qi L, Raffel LJ, Rich SS, Rodriquez EJ, Tarazona-Santos E, Taylor KD, Umans JG, Wen J, Young BA, Yu Z, Zhang Y, Ida Chen YD, Rundek T, Rotter JI, Cruz M, Fornage M, Lima-Costa MF, Pereira AC, Paré G, Natarajan P, Cole SA, Carson AP, Lange LA, Li Y, Perez-Stable EJ, Do R, Charchar FJ, Tomaszewski M, Mychaleckyj JC, Rotimi C, Morris AP, Franceschini N. Cell Genom. 2024 Jan 10;4(1):100468. PMID: 38190104. PMC10794846.
Clonal Hematopoiesis and Cardiovascular Disease in Patients With Multiple Myeloma Undergoing Hematopoietic Cell Transplant. Rhee JW, Pillai R, He T, Bosworth A, Chen S, Atencio L, Oganesyan A, Peng K, Guzman T, Lukas K, Sigala B, Iukuridze A, Lindenfeld L, Jamal F, Natarajan P, Goldsmith S, Krishnan A, Rosenzweig M, Wong FL, Forman SJ, Armenian S. JAMA Cardiol. 2024 Jan 1;9(1):16-24. PMID: 37938837. PMC10633387.
The Science of Precision Prevention: Research Opportunities and Clinical Applications to Reduce Cardiovascular Health Disparities. Pearson TA, Vitalis D, Pratt C, Campo R, Armoundas AA, Au D, Beech B, Brazhnik O, Chute CG, Davidson KW, Diez-Roux AV, Fine LJ, Gabriel D, Groenveld P, Hall J, Hamilton AB, Hu H, Ji H, Kind A, Kraus WE, Krumholz H, Mensah GA, Merchant RM, Mozaffarian D, Murray DM, Neumark-Sztainer D, Petersen M, Goff D. JACC Adv. 2024 Jan;3(1):100759. PMID: 38375059. PMC10876066.
Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease. Zhu QM, Hsu YH, Lassen FH, MacDonald BT, Stead S, Malolepsza E, Kim A, Li T, Mizoguchi T, Schenone M, Guzman G, Tanenbaum B, Fornelos N, Carr SA, Gupta RM, Ellinor PT, Lage K. Commun Biol. 2024 Jan 12;7(1):87. PMID: 38216744. PMC10786878.
SGLT2 Inhibitors in Patients With Cancer Therapy-Related Cardiotoxicity: An Unexpected Benefit? Oren O, Natarajan P, Bhatt DL. JACC Heart Fail. 2024 Jan;12(1):79-82. PMID: 37999662.
Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease. Rogers MA, Bartoli-Leonard F, Zheng KH, Small AM, Chen HY, Clift CL, Asano T, Kuraoka S, Blaser MC, Perez KA, Natarajan P, Yeang C, Stroes ESG, Tsimikas S, Engert JC, Thanassoulis G, O’Donnell CJ, Aikawa M, Singh SA, Aikawa E. Circulation. 2024 Jan 30;149(5):391-401. PMID: 37937463. PMC10842618.
Deep learned representations of the resting 12-lead electrocardiogram to predict at peak exercise. Khurshid S, Churchill TW, Diamant N, Di Achille P, Reeder C, Singh P, Friedman SF, Wasfy MM, Alba GA, Maron BA, Systrom DM, Wertheim BM, Ellinor PT, Ho JE, Baggish AL, Batra P, Lubitz SA, Guseh JS. Eur J Prev Cardiol. 2024 Jan 25;31(2):252-262. PMID: 37798122. PMC10809171.
Potential for Bridging Treatment Gaps in Cardiovascular Health in Asia With Inclusive Clinical Trials. Patel AP. JACC Asia. 2024 Jan 23;4(2):135-137. PMID: 38371288. PMC10866730.

2023

Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification. de Vries PS, Conomos MP, Singh K, Nicholson CJ, Jain D, Hasbani NR, Jiang W, Lee S, Lino Cardenas CL, Lutz SM, Wong D, Guo X, Yao J, Young EP, Tcheandjieu C, Hilliard AT, Bis JC, Bielak LF, Brown MR, Musharoff S, Clarke SL, Terry JG, Palmer ND, Yanek LR, Xu H, Heard-Costa N, Wessel J, Selvaraj MS, Li RH, Sun X, Turner AW, Stilp AM, Khan A, Newman AB, Rasheed A, Freedman BI, Kral BG, McHugh CP, Hodonsky C, Saleheen D, Herrington DM, Jacobs DR Jr, Nickerson DA, Boerwinkle E, Wang FF, Heiss G, Jun G, Kinney GL, Sigurslid HH, Doddapaneni H, Hall IM, Bensenor IM, Broome J, Crapo JD, Wilson JG, Smith JA, Blangero J, Vargas JD, Mosquera JV, Smith JD, Viaud-Martinez KA, Ryan KA, Young KA, Taylor KD, Lange LA, Emery LS, Bittencourt MS, Budoff MJ, Montasser ME, Yu M, Mahaney MC, Mahamdeh MS, Fornage M, Franceschini N, Lotufo PA, Natarajan P, Wong Q, Mathias RA, Gibbs RA, Do R, Mehran R, Tracy RP, Kim RW, Nelson SC, Damrauer SM, Kardia SLR, Rich SS, Fuster V, Napolioni V, Zhao W, Tian W, Yin X, Min YI, Manning AK, Peloso G, Kelly TN, O’Donnell CJ, Morrison AC, Curran JE, Zapol WM, Bowden DW, Becker LC, Correa A, Mitchell BD, Psaty BM, Carr JJ, Pereira AC, Assimes TL, Stitziel NO, Hokanson JE, Laurie CA, Rotter JI, Vasan RS, Post WS, Peyser PA, Miller CL, Malhotra R. Nat Cardiovasc Res. 2023 Dec;2(12):1159-1172. PMID: 38817323. PMC11138106.
Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research. Costanzo MC, Roselli C, Brandes M, Duby M, Hoang Q, Jang D, Koesterer R, Kudtarkar P, Moriondo A, Nguyen T, Ruebenacker O, Smadbeck P, Sun Y, Butterworth AS, Aragam KG, Lumbers RT, Khera AV, Lubitz SA, Ellinor PT, Gaulton KJ, Flannick J, Burtt NP. Circ Genom Precis Med. 2023 Dec;16(6):e004181. PMID: 37814896. PMC10843166.
Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways. Spanos M, Gokulnath P, Chatterjee E, Li G, Varrias D, Das S. Extracell Vesicle. 2023 Dec;2:100025. PMID: 38188000. PMC10768935.
Concordance of a High Lipoprotein(a) Concentration Among Relatives. Reeskamp LF, Tromp TR, Patel AP, Ibrahim S, Trinder M, Haidermota S, Hovingh GK, Stroes ESG, Natarajan P, Khera AV. JAMA Cardiol. 2023 Dec 1;8(12):1111-1118. PMID: 37819667. PMC10568442.
Diminished muscle integrity in patients with fibrodysplasia ossificans progressiva assessed with at-home electrical impedance myography. Farid A, Golden E, Robicheau S, Hu A, Cheung K, Yu PB, Rutkove SB, Upadhyay J. Sci Rep. 2022 Dec 3;12(1):20908. PMID: 36463382. PMC9719538.
Machine Learning in Invasive and Noninvasive Coronary Angiography. Unlu O, Fahed AC. Curr Atheroscler Rep. 2023 Dec;25(12):1025-1033. PMID: 38095805. Review.
Clinical applications of polygenic risk score for coronary artery disease through the life course. Fahed AC, Natarajan P. Atherosclerosis. 2023 Dec;386:117356. PMID: 37931336. PMC10842813. Review.
Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Schoenmakers E, Marelli F, Jørgensen HF, Visser WE, Moran C, Groeneweg S, Avalos C, Jurgens SJ, Figg N, Finigan A, Wali N, Agostini M, Wardle-Jones H, Lyons G, Rusk R, Gopalan D, Twiss P, Visser JJ, Goddard M, Nashef SAM, Heijmen R, Clift P, Sinha S, Pirruccello JP, Ellinor PT, Busch-Nentwich EM, Ramirez-Solis R, Murphy MP, Persani L, Bennett M, Chatterjee K. Nat Commun. 2023 Dec 2;14(1):7994. PMID: 38042913. PMC10693596.
Skull bone marrow channels as immune gateways to the central nervous system. Mazzitelli JA, Pulous FE, Smyth LCD, Kaya Z, Rustenhoven J, Moskowitz MA, Kipnis J, Nahrendorf M. Nat Neurosci. 2023 Dec;26(12):2052-2062. PMID: 37996526. PMC10894464. Review.
Accuracy and variability of cardiologist interpretation of single lead electrocardiograms for atrial fibrillation: The VITAL-AF trial. Pipilas DC, Khurshid S, Atlas SJ, Ashburner JM, Lipsanopoulos AT, Borowsky LH, Guan W, Ellinor PT, McManus DD, Singer DE, Chang Y, Lubitz SA. Am Heart J. 2023 Nov;265:92-103. PMID: 37451355. PMC11194686.
Transcriptional profile of the rat cardiovascular system at single cell resolution. Arduini A, Fleming SJ, Xiao L, Hall AW, Akkad AD, Chaffin M, Bendinelli KJ, Tucker NR, Papangeli I, Mantineo H, Babadi M, Stegmann CM, García-Cardeña G, Lindsay ME, Klattenhoff C, Ellinor PT. bioRxiv [Preprint]. 2023 Nov 16:2023.11.14.567085. PMID: 38014050. PMC10680727.
Massive underrepresentation of Arabs in genomic studies of common disease. Bhattacharya R, Chen N, Shim I, Kuwahara H, Gao X, Alkuraya FS, Fahed AC. Genome Med. 2023 Nov 22;15(1):99. PMID: 37993966. PMC10664351.
MSGene: Derivation and validation of a multistate model for lifetime risk of coronary artery disease using genetic risk and the electronic health record. Urbut SM, Yeung MW, Khurshid S, Cho SMJ, Schuermans A, German J, Taraszka K, Fahed AC, Ellinor P, Trinquart L, Parmigiani G, Gusev A, Natarajan P. medRxiv [Preprint]. 2023 Nov 8:2023.11.08.23298229. PMID: 37986972. PMC10659503.
Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction. Lau ES, Roshandelpoor A, Zarbafian S, Wang D, Guseh JS, Allen N, Varadarajan V, Nayor M, Shah RV, Lima JAC, Shah SJ, Yu B, Alotaibi M, Cheng S, Jain M, Lewis GD, Ho JE. Nat Commun. 2023 Nov 20;14(1):7557. PMID: 37985769. PMC10662264.
Infertility and Subclinical Antecedents of Heart Failure With Preserved Ejection Fraction in the Framingham Heart Study. Zhou JC, Zhao Y, Bello N, Benjamin EJ, Ramachandran VS, Levy D, Cheng S, Murabito JM, Ho JE, Lau ES. J Card Fail. 2023 Nov 17:S1071-9164(23)00872-2. PMID: 37979670
A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies. Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly T, Konigsberg I, Kooperberg C, Kral BG, Li C, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Palmer ND, Peyser PA, Psaty BM, Raffield LM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari H, Vasan RS, Wang Z, Yanek LR, Yu B; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X. bioRxiv [Preprint]. 2023 Nov 2:2023.10.30.564764. PMID: 37961350.
Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis. Mosquera JV, Auguste G, Wong D, Turner AW, Hodonsky CJ, Alvarez-Yela AC, Song Y, Cheng Q, Lino Cardenas CL, Theofilatos K, Bos M, Kavousi M, Peyser PA, Mayr M, Kovacic JC, Björkegren JLM, Malhotra R, Stukenberg PT, Finn AV, van der Laan SW, Zang C, Sheffield NC, Miller CL. Cell Rep. 2023 Nov 28;42(11):113380. PMID: 37950869.
Deep Learning-Enabled Assessment of Left Heart Structure and Function Predicts Cardiovascular Outcomes. Lau ES, Di Achille P, Kopparapu K, Andrews CT, Singh P, Reeder C, Al-Alusi M, Khurshid S, Haimovich JS, Ellinor PT, Picard MH, Batra P, Lubitz SA, Ho JE. J Am Coll Cardiol. 2023 Nov 14;82(20):1936-1948. PMID: 37940231.
Clinical perspectives on the adoption of the artificial intelligence-enabled electrocardiogram. Khurshid S. J Electrocardiol. 2023 Nov-Dec;81:142-145. PMID: 37696174. Review.
Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in the CETP Gene. Yu C, Bakshi A, Watts GF, Renton AE, Fulton-Howard B, Goate AM, Natarajan P, Chasman DI, Robman L, Woods RL, Guymer R, Wolfe R, Thao LTP, McNeil JJ, Tonkin AM, Nicholls SJ, Lacaze P. J Am Heart Assoc. 2023 Nov 7;12(21):e031459. PMID: 37929782.
Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling. Kim E, Kim H, Jedrychowski MP, Bakiasi G, Park J, Kruskop J, Choi Y, Kwak SS, Quinti L, Kim DY, Wrann CD, Spiegelman BM, Tanzi RE, Choi SH. Neuron. 2023 Nov 15;111(22):3619-3633.e8. PMID: 37689059.
The GenoVA study: Equitable implementation of a pragmatic randomized trial of polygenic-risk scoring in primary care. Vassy JL, Brunette CA, Lebo MS, MacIsaac K, Yi T, Danowski ME, Alexander NVJ, Cardellino MP, Christensen KD, Gala M, Green RC, Harris E, Jones NE, Kerman BJ, Kraft P, Kulkarni P, Lewis ACF, Lubitz SA, Natarajan P, Antwi AA. Am J Hum Genet. 2023 Nov 2;110(11):1841-1852. PMID: 37922883. Clinical Trial.
Pragmatic Approach to Applying Polygenic Risk Scores to Diverse Populations. Patel AP, Fahed AC. Curr Protoc. 2023 Nov;3(11):e911. PMID: 37921506.
Circulating extracellular vesicles in human cardiorenal syndrome promote renal injury in a kidney-on-chip system. Chatterjee E, Rodosthenous RS, Kujala V, Gokulnath P, Spanos M, Lehmann HI, de Oliveira GP, Shi M, Miller-Fleming TW, Li G, Ghiran IC, Karalis K, Lindenfeld J, Mosley JD, Lau ES, Ho JE, Sheng Q, Shah R, Das S. JCI Insight. 2023 Nov 22;8(22):e165172. PMID: 37707956.
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. Chen CW, Zhang L, Dutta R, Niroula A, Miller PG, Gibson CJ, Bick AG, Reyes JM, Lee YT, Tovy A, Gu T, Waldvogel S, Chen YH, Venters BJ, Estève PO, Pradhan S, Keogh MC, Natarajan P, Takahashi K, Sperling AS, Goodell MA. Cell Stem Cell. 2023 Nov 2;30(11):1503-1519.e8. PMID: 37863054.
Outcomes of Chronic Total Occlusion Percutaneous Coronary Interventions in Patients With Previous Coronary Artery Bypass Graft Surgery. Alexandrou M, Kostantinis S, Rempakos A, Simsek B, Karacsonyi J, Choi JW, Poommipanit P, Alaswad K, Basir MB, Megaly M, Davies R, Benton S, Jaffer FA, Karmpaliotis D, Azzalini L, Kearney KE, ElGuindy AM, Rafeh NA, Goktekin O, Gorgulu S, Khatri JJ, Aygul N, Jaber W, Nicholson W, Rinfret S, Krestyaninov O, Khelimskii D, Rangan BV, Mastrodemos OC, Allana SS, Sandoval Y, Burke MN, Brilakis ES. Am J Cardiol. 2023 Oct 15;205:40-49. PMID: 37586120.
Genetic and clinical factors underlying a self-reported family history of heart disease. Jowell AR, Bhattacharya R, Marnell C, Wong M, Haidermota S, Trinder M, Fahed AC, Peloso GM, Honigberg MC, Natarajan P. Eur J Prev Cardiol. 2023 Oct 26;30(15):1571-1579. PMID: 37011137.
The association of eicosanoids and eicosanoid-related metabolites with pulmonary hypertension. McNeill JN, Roshandelpoor A, Alotaibi M, Choudhary A, Jain M, Cheng S, Zarbafian S, Lau ES, Lewis GD, Ho JE. Eur Respir J. 2023 Oct 19;62(4):2300561. PMID: 37857430.
Decoding Genetics, Ancestry, and Geospatial Context for Precision Health. Koyama S, Wang Y, Paruchuri K, Uddin MM, Cho SMJ, Urbut SM, Haidermota S, Hornsby WE, Green RC, Daly MJ, Neale BM, Ellinor PT, Smoller JW, Lebo MS, Karlson EW, Martin AR, Natarajan P. medRxiv [Preprint]. 2023 Oct 25:2023.10.24.23297096. PMID: 37961173.
Clinical utility of polygenic scores for cardiometabolic disease in Arabs. Shim I, Kuwahara H, Chen N, Hashem MO, AlAbdi L, Abouelhoda M, Won HH, Natarajan P, Ellinor PT, Khera AV, Gao X, Alkuraya FS, Fahed AC. Nat Commun. 2023 Oct 18;14(1):6535. PMID: 37852978.
Treatment of calcific arterial disease via enhancement of autophagy using GSK343. Lino Cardenas CL, Jiang W, Kajuluri LP, Singh K, Ostrom K, Li R, Cherbonneau F, Boerboom S, Birchenough C, Roh K, Chou EL, Shahrooz Z, Nicholson C, Johnson AL, Lee S, Ichinose F, Bloch DB, Nigwekar S, Ellinor PT, Musolino P, Lindsay ME, Dou Z, Miller CL, Malhotra R. iScience. 2023 Oct 29;26(11):108360. PMID: 38033629.
Metabolic Dysfunction in Aortic Stenosis: A Key Piece of the Pathophysiological Puzzle. Sosnovik DE, Elmariah S. Circ Cardiovasc Imaging. 2023 Oct;16(10):e015977. PMID: 37847765
Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study. Wang Y, Selvaraj MS, Li X, Li Z, Holdcraft JA, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Cade BE, Carlson JC, Carson AP, Chen YI, Curran JE, de Vries PS, Dutcher SK, Ellinor PT, Floyd JS, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, Guo X, He J, Heard-Costa N, Hildalgo B, Hou L, Irvin MR, Joehanes R, Kaplan RC, Kardia SL, Kelly TN, Kim R, Kooperberg C, Kral BG, Levy D, Li C, Liu C, Lloyd-Jone D, Loos RJ, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Murabito JM, Naseri T, O’Connell JR, Palmer ND, Preuss MH, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Ruepena MS, Sheu WH, Smith JA, Smith A, Tiwari HK, Tsai MY, Viaud-Martinez KA, Wang Z, Yanek LR, Zhao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Rotter JI, Lin X, Natarajan P, Peloso GM. Am J Hum Genet. 2023 Oct 5;110(10):1704-1717. PMID: 37802043.
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification. Kavousi M, Bos MM, Barnes HJ, Lino Cardenas CL, Wong D, Lu H, Hodonsky CJ, Landsmeer LPL, Turner AW, Kho M, Hasbani NR, de Vries PS, Bowden DW, Chopade S, Deelen J, Benavente ED, Guo X, Hofer E, Hwang SJ, Lutz SM, Lyytikäinen LP, Slenders L, Smith AV, Stanislawski MA, van Setten J, Wong Q, Yanek LR, Becker DM, Beekman M, Budoff MJ, Feitosa MF, Finan C, Hilliard AT, Kardia SLR, Kovacic JC, Kral BG, Langefeld CD, Launer LJ, Malik S, Hoesein FAAM, Mokry M, Schmidt R, Smith JA, Taylor KD, Terry JG, van der Grond J, van Meurs J, Vliegenthart R, Xu J, Young KA, Zilhão NR, Zweiker R, Assimes TL, Becker LC, Bos D, Carr JJ, Cupples LA, de Kleijn DPV, de Winther M, den Ruijter HM, Fornage M, Freedman BI, Gudnason V, Hingorani AD, Hokanson JE, Ikram MA, Išgum I, Jacobs DR Jr, Kähönen M, Lange LA, Lehtimäki T, Pasterkamp G, Raitakari OT, Schmidt H, Slagboom PE, Uitterlinden AG, Vernooij MW, Bis JC, Franceschini N, Psaty BM, Post WS, Rotter JI, Björkegren JLM, O’Donnell CJ, Bielak LF, Peyser PA, Malhotra R, van der Laan SW, Miller CL. Nat Genet. 2023 Oct;55(10):1651-1664. PMID: 37770635.
Prediction of experimental cardiac magnetostimulation thresholds using pig-specific body models. Klein V, Davids M, Vendramini L, Ferris NG, Schad LR, Sosnovik DE, Nguyen CT, Wald LL, Guérin B. Magn Reson Med. 2023 Oct;90(4):1594-1609. PMID: 37288580.
Vagus Nerve Stimulation and Inflammation in Cardiovascular Disease: A State-of-the-Art Review. Bazoukis G, Stavrakis S, Armoundas AA. J Am Heart Assoc. 2023 Oct 3;12(19):e030539. PMID: 37721168. Review.
Zebrafish as a high throughput model for organ preservation and transplantation research. Da Silveira Cavalcante L, Lopera Higuita M, González-Rosa JM, Marques B, To S, Pendexter CA, Cronin SEJ, Gopinathan K, de Vries RJ, Ellett F, Uygun K, Langenau DM, Toner M, Tessier SN. FASEB J. 2023 Oct;37(10):e23187. PMID: 37718489.
Angiogenesis Redux: An Overall Protective Role of VEGF/KDR Signaling in the Microvasculature in Pulmonary Arterial Hypertension. Zhong Y, Yu PB. Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):1784-1787. PMID: 37675636.
Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis. Deflaux N, Selvaraj MS, Condon HR, Mayo K, Haidermota S, Basford MA, Lunt C, Philippakis AA, Roden DM, Denny JC, Musick A, Collins R, Allen N, Effingham M, Glazer D, Natarajan P, Bick AG. Nat Commun. 2023 Sep 5;14(1):5419. PMID: 37669985.
Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender. Fleming SJ, Chaffin MD, Arduini A, Akkad AD, Banks E, Marioni JC, Philippakis AA, Ellinor PT, Babadi M. Nat Methods. 2023 Sep;20(9):1323-1335. PMID: 37550580.
Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk. Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P. J Clin Invest. 2023 Sep 15;133(18):e168597. PMID: 37498674.
Representation of Race and Ethnicity in the Contemporary US Health Cohort All of Us Research Program. Kathiresan N, Cho SMJ, Bhattacharya R, Truong B, Hornsby W, Natarajan P. JAMA Cardiol. 2023 Sep 1;8(9):859-864. PMID: 37585212.
Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis. Kim MS, Song M, Kim B, Shim I, Kim DS, Natarajan P, Do R, Won HH. Cell Rep Med. 2023 Sep 19;4(9):101112. PMID: 37582372.
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma. Benson MD, Eisman AS, Tahir UA, Katz DH, Deng S, Ngo D, Robbins JM, Hofmann A, Shi X, Zheng S, Keyes M, Yu Z, Gao Y, Farrell L, Shen D, Chen ZZ, Cruz DE, Sims M, Correa A, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Guo X, Yao J, Chen YI, Manichaikul AW, Jain D, Yang Q; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Bouchard C, Sarzynski MA, Rich SS, Rotter JI, Wang TJ, Wilson JG, Clish CB, Sarkar IN, Natarajan P, Gerszten RE. Cell Metab. 2023 Sep 5;35(9):1646-1660.e3. PMID: 37582364.
Cardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury. Rhee J, Freeman R, Roh K, Lyons M, Xiao C, Zlotoff D, Yeri A, Li H, Guerra J, Guseh JS, Kuznetsov A, Houstis N, Roh J, Damilano F, Liu X, Silverman M, Kwong R, Das S, Rosenzweig A. Circ Res. 2023 Sep 15;133(7):651-653. PMID: 37638415.
Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study. Cho SMJ, Koyama S, Honigberg MC, Surakka I, Haidermota S, Ganesh S, Patel AP, Bhattacharya R, Lee H, Kim HC, Natarajan P. Eur Heart J. 2023 Sep 21;44(36):3456-3465. PMID: 37350734.
Quantifying the causal impact of biological risk factors on healthcare costs. Lee J, Jukarainen S, Karvanen A, Dixon P, Davies NM, Smith GD, Natarajan P, Ganna A. Nat Commun. 2023 Sep 13;14(1):5672. PMID: 37704630.
Bayesian multivariate genetic analysis improves translational insights. Urbut SM, Koyama S, Hornsby W, Bhukar R, Kheterpal S, Truong B, Selvaraj MS, Neale B, O’Donnell CJ, Peloso GM, Natarajan P. iScience. 2023 Sep 9;26(10):107854. PMID: 37766997.
Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis. Uddin MM, Saadatagah S, Niroula A, Yu B, Hornsby W, Ganesh S, Lannery K, Shuermans A, Honigberg MC, Bick AG, Libby P, Ebert BL, Ballantyne CM, Natarajan P. medRxiv [Preprint]. 2023 Sep 7:2023.09.05.23295093. PMID: 37732181.
Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review. Figtree GA, Vernon ST, Harmer JA, Gray MP, Arnott C, Bachour E, Barsha G, Brieger D, Brown A, Celermajer DS, Channon KM, Chew NWS, Chong JJH, Chow CK, Cistulli PA, Ellinor PT, Grieve SM, Guzik TJ, Hagström E, Jenkins A, Jennings G, Keech AC, Kott KA, Kritharides L, Mamas MA, Mehran R, Meikle PJ, Natarajan P, Negishi K, O’Sullivan J, Patel S, Psaltis PJ, Redfern J, Steg PG, Sullivan DR, Sundström J, Vogel B, Wilson A, Wong D, Bhatt DL, Kovacic JC, Nicholls SJ; CRE for CAD Collaborators. J Am Coll Cardiol. 2023 Sep 26;82(13):1343-1359. PMID: 37730292. Review.
Comparison of the 11-Day Adhesive ECG Patch Monitor and 24-h Holter Tests to Assess the Response to Antiarrhythmic Drug Therapy in Paroxysmal Atrial Fibrillation. Kim S, Choi Y, Lee K, Kim SH, Kim H, Shin S, Park S, Oh YS. Diagnostics (Basel). 2023 Sep 28;13(19):3078. PMID: 37835822.
Noninvasive Quantification of Radiation-Induced Lung Injury using a Targeted Molecular Imaging Probe. Abston E, Zhou IY, Saenger JA, Shuvaev S, Akam E, Esfahani SA, Hariri LP, Rotile NJ, Crowley E, Montesi SB, Humblet V, Arabasz G, Catana C, Fintelmann FJ, Caravan P, Lanuti M. medRxiv [Preprint]. 2023 Sep 26:2023.09.25.23295897. PMID: 37808864.
The Fall of Roe: the Devastating Impact of the Dobbs vs Jackson Decision on Women Living With Heart Failure. Rosenblum HR, Haythe JH, Lau ES. J Card Fail. 2023 Aug;29(8):1207-1209. PMID: 37562897.
Protein Biomarkers of Early Menopause and Incident Cardiovascular Disease. Ramirez MF, Honigberg M, Wang D, Parekh JK, Bielawski K, Courchesne P, Larson MD, Levy D, Murabito JM, Ho JE, Lau ES. J Am Heart Assoc. 2023 Aug 15;12(16):e028849. PMID: 37548169.
Genetic insights into resting heart rate and its role in cardiovascular disease. van de Vegte YJ, Eppinga RN, van der Ende MY, Hagemeijer YP, Mahendran Y, Salfati E, Smith AV, Tan VY, Arking DE, Ntalla I, Appel EV, et al. Nat Commun. 2023 Aug 2;14(1):4646. PMID: 37532724.
Publisher Correction: LungElast-an open-source, flexible, low-cost, microprocessor-controlled mouse lung elastometer. Roberts JD Jr. Sci Rep. 2023 Aug 1;13(1):12460. PMID: 37528185.
Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women. Schuermans A, Nakao T, Uddin MM, Hornsby W, Ganesh S, Shadyab AH, Liu S, Haring B, Shufelt CL, Taub MA, Mathias RA, Kooperberg C, Reiner AP, Bick AG, Manson JE, Natarajan P, Honigberg MC. Circ Res. 2023 Aug 18;133(5):376-386. PMID: 37489536.
Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion. Martí-Pàmies Í, Thoonen R, Morley M, Graves L, Tamez J, Caplan A, McDaid K, Yao V, Hindle A, Gerszten RE, Farrell LA, Li L, Tseng YH, Profeta G, Buys ES, Bloch DB, Scherrer-Crosbie M. Circ Res. 2023 Aug 4;133(4):353-365. PMID: 37462036.
Identifying high risk clinical phenogroups of pulmonary hypertension through a clustering analysis. Rambarat P, Zern EK, Wang D, Roshandelpoor A, Zarbafian S, Liu EE, Wang JK, McNeill JN, Andrews CT, Pomerantsev EV, Diamant N, Batra P, Lubitz SA, Picard MH, Ho JE. PLoS One. 2023 Aug 25;18(8):e0290553. PMID: 37624825.
Loss of the Atrial Fibrillation-Related Gene, Zfhx3, Results in Atrial Dilation and Arrhythmias. Jameson HS, Hanley A, Hill MC, Xiao L, Ye J, Bapat A, Ronzier E, Hall AW, Hucker WJ, Clauss S, Barazza M, Silber E, Mina JA, Tucker NR, Mills RW, Dong JT, Milan DJ, Ellinor PT. Circ Res. 2023 Aug 4;133(4):313-329. PMID: 37449401.
Characteristics and Attitudes of Wearable Device Users and Non-Users in a Large Healthcare System. Venn RA, Khurshid S, Grayson M, Ashburner JM, Al-Alusi MA, Chang Y, Foulkes A, Ellinor PT, McManus DD, Singer DE, Atlas SJ, Lubitz SA. medRxiv [Preprint]. 2023 Aug 12:2023.08.10.23293960. PMID: 37609134.
An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses. Kim JY, Song M, Kim MS, Natarajan P, Do R, Myung W, Won HH. BMC Med. 2023 Aug 21;21(1):316. PMID: 37605270.
AORTA Gene: Polygenic prediction improves detection of thoracic aortic aneurysm. Pirruccello JP, Khurshid S, Lin H, Lu-Chen W, Zamirpour S, Kany S, Raghavan A, Koyama S, Vasan RS, Benjamin EJ, Lindsay ME, Ellinor PT. medRxiv [Preprint]. 2023 Aug 25:2023.08.23.23294513. PMID: 37662232.
Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions. Zhang W, Petri K, Ma J, Lee H, Tsai CL, Joung JK, Yeh JJ. bioRxiv [Preprint]. 2023 Aug 15:2023.08.14.553324. PMID: 37645936.
Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries. Bai Y, Li G, Yung L, Yu PB, Ai X. Am J Physiol Lung Cell Mol Physiol. 2023 Aug 1;325(2):L114-L124. PMID: 37278410.
Genetic Susceptibility to Atrial Fibrillation Identified via Deep Learning of 12-Lead Electrocardiograms. Wang X, Khurshid S, Choi SH, Friedman S, Weng LC, Reeder C, Pirruccello JP, Singh P, Lau ES, Venn R, Diamant N, Di Achille P, Philippakis A, Anderson CD, Ho JE, Ellinor PT, Batra P, Lubitz SA. Circ Genom Precis Med. 2023 Aug;16(4):340-349. PMID: 37278238.
Ketone ester supplementation suppresses cardiac inflammation and improves cardiac energetics in a swine model of acute myocardial infarction. Yurista SR, Eder RA, Welsh A, Jiang W, Chen S, Foster AN, Mauskapf A, Tang WHW, Hucker WJ, Coll-Font J, Rosenzweig A, Nguyen CT. Metabolism. 2023 Aug;145:155608. PMID: 37268056.
Association of genetic risk and outcomes in patients with atrial fibrillation: interactions with early rhythm control in the EAST-AFNET4 trial. Kany S, Al-Taie C, Roselli C, Pirruccello JP, Borof K, Reinbold C, Suling A, Krause L, Reissmann B, Schnabel RB, Zeller T, Zapf A, Wegscheider K, Fabritz L, Ellinor PT, Kirchhof P. Cardiovasc Res. 2023 Aug 7;119(9):1799-1810. PMID: 37264683. Clinical Trial.
Identification of the Key Immune Cells and Genes for the Diagnostics and Therapeutics of Meningioma. Chen J, Hua L, Xu X, Jiapaer Z, Deng J, Wang D, Zhang L, Li G, Gong Y. World Neurosurg. 2023 Aug;176:e501-e514. PMID: 37263494.
Genetic Burden of TNNI3K in Diagnostic Testing of Patients With Dilated Cardiomyopathy and Supraventricular Arrhythmias. Pham C, Andrzejczyk K, Jurgens SJ, Lekanne Deprez R, Palm KCA, Vermeer AMC, Nijman J, Christiaans I, Barge-Schaapveld DQCM, van Dessel PFHM, Beekman L, Choi SH, Lubitz SA, Skoric-Milosavljevic D, van den Bersselaar L, Jansen PR, Copier JS, Ellinor PT, Wilde AAM, Bezzina CR, Lodder EM. Circ Genom Precis Med. 2023 Aug;16(4):328-336. PMID: 37199186.
Common and rare variants associated with cardiometabolic traits across 98,622 whole-genome sequences in the All of Us research program. Wang X, Ryu J, Kim J, Ramirez A, Mayo KR; All of Us Research Program; Condon H, Vaitinadin NS, Ohno-Machado L, Talavera GA, Ellinor PT, Lubitz SA, Choi SH. J Hum Genet. 2023 Aug;68(8):565-570. PMID: 37072623.
Autonomic Nervous System and Cardiac Metabolism: Links Between Autonomic and Metabolic Remodeling in Atrial Fibrillation. Chakraborty P, Farhat K, Po SS, Armoundas AA, Stavrakis S. JACC Clin Electrophysiol. 2023 Jul;9(7 Pt 2):1196-1206. PMID: 37086229. Review.
Novel AI-based HRV analysis (NAIHA) in healthcare automation and related applications. Rahul LR, Sarkar R, Sengupta A, Chandra BS, Jana S. J Electrocardiol. 2023 Jul-Aug;79:112-121. PMID: 37031632.
The common pathobiology between coronary artery disease and calcific aortic stenosis: Evidence and clinical implications. Abdul-Rahman T, Lizano-Jubert I, Garg N, Talukder S, Lopez PP, Awuah WA, Shah R, Chambergo D, Cantu-Herrera E, Farooqi M, Pyrpyris N, de Andrade H, Mares AC, Gupta R, Aldosoky W, Mir T, Lavie CJ, Abohashem S. Prog Cardiovasc Dis. 2023 Jul-Aug;79:89-99. PMID: 37302652. Review.
Accelerometer-Derived “Weekend Warrior” Physical Activity and Incident Cardiovascular Disease. Khurshid S, Al-Alusi MA, Churchill TW, Guseh JS, Ellinor PT. JAMA. 2023 Jul 18;330(3):247-252. PMID: 37462704.
Venous Thromboembolism in Pregnancy: Challenges and Solutions. Varrias D, Spanos M, Kokkinidis DG, Zoumpourlis P, Kalaitzopoulos DR. Vasc Health Risk Manag. 2023 Jul 20;19:469-484. PMID: 37492280. Review.
The Cardiovascular Impact and Genetics of Pericardial Adiposity. Rämö JT, Kany S, Hou CR, Friedman SF, Roselli C, Nauffal V, Koyama S, Karjalainen J; FinnGen; Maddah M, Palotie A, Ellinor PT, Pirruccello JP. medRxiv [Preprint]. 2023 Jul 18:2023.07.16.23292729. PMID: 37502935.
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus. Kwak SH, Hernandez-Cancela RB, DiCorpo DA, Condon DE, Merino J, Wu P, Brody JA, Yao J, Guo X, Ahmadizar F, Meyer M, Sincan M, Mercader JM, Lee S, Haessler J, Vy HMT, Lin Z, Armstrong ND, Gu S, Tsao NL, Lange LA, Wang N, Wiggins KL, Trompet S, Liu S, Loos RJF, Judy R, Schroeder PH, Hasbani NR, Bos MM, Morrison AC, Jackson RD, Reiner AP, Manson JE, Chaudhary NS, Carmichael LK, Chen YI, Taylor KD, Ghanbari M, van Meurs J, Pitsillides AN, Psaty BM, Noordam R, Do R, Park KS, Jukema JW, Kavousi M, Correa A, Rich SS, Damrauer SM, Hajek C, Cho NH, Irvin MR, Pankow JS, Nadkarni GN, Sladek R, Goodarzi MO, Florez JC, Chasman DI, Heckbert SR, Kooperberg C, Dupuis J, Malhotra R, de Vries PS, Liu CT, Rotter JI, Meigs JB. medRxiv [Preprint]. 2023 Jul 28:2023.07.25.23293180. PMID: 37546893.
Clinical and Genetic Atrial Fibrillation Risk and Discrimination of Cardioembolic From Noncardioembolic Stroke. Weng LC, Khurshid S, Gunn S, Trinquart L, Lunetta KL, Xu H; NINDS Stroke Genetics Network*; Benjamin EJ, Ellinor PT, Anderson CD, Lubitz SA. Stroke. 2023 Jul;54(7):1777-1785. PMID: 37363945.
Recruited macrophages elicit atrial fibrillation. Hulsmans M, Schloss MJ, Lee IH, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous FE, Keller D, Bening C, Green U, Lennerz JK, Mitchell RN, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong CS, Pierson RN, Aster JC, Rohde D, Wojtkiewicz GR, Weissleder R, Swirski FK, Tellides G, Tolis G Jr, Melnitchouk S, Milan DJ, Ellinor PT, Naxerova K, Nahrendorf M. Science. 2023 Jul 14;381(6654):231-239. PMID: 37440641.
LungElast-an open-source, flexible, low-cost, microprocessor-controlled mouse lung elastometer. Roberts JD Jr. Sci Rep. 2023 Jul 12;13(1):11246. PMID: 37438462.
A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease. Patel AP, Wang M, Ruan Y, Koyama S, Clarke SL, Yang X, Tcheandjieu C, Agrawal S, Fahed AC, Ellinor PT; Genes & Health Research Team; the Million Veteran Program; Tsao PS, Sun YV, Cho K, Wilson PWF, Assimes TL, van Heel DA, Butterworth AS, Aragam KG, Natarajan P, Khera AV. Nat Med. 2023 Jul;29(7):1793-1803. PMID: 37414900.
Effect of clinic-based single-lead electrocardiogram rhythm assessment on oral anticoagulation prescriptions in patients with previously diagnosed atrial fibrillation. Ashburner JM, Chang Y, Borowsky LH, Khurshid S, McManus DD, Ellinor PT, Lubitz SA, Singer DE, Atlas SJ. Heart Rhythm O2. 2023 Jul 12;4(8):469-477. PMID: 37645259.
Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia. Plotnikov MB, Chernysheva GA, Smol’yakova VI, Aliev OI, Anishchenko AM, Ulyakhina OA, Trofimova ES, Ligacheva AA, Anfinogenova ND, Osipenko AN, Kovrizhina AR, Khlebnikov AI, Schepetkin IA, Drozd AG, Plotnikov EV, Atochin DN, Quinn MT. Pharmaceuticals (Basel). 2023 Jul 25;16(8):1057. PMID: 37630972.
Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease. Limpitikul WB, Das S. J Cardiovasc Dev Dis. 2023 Jul 30;10(8):323. PMID: 37623336. Review.
Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood. Schuermans A, Nakao T, Ruan Y, Koyama S, Yu Z, Uddin MM, Haidermota S, Hornsby W, Lewandowski AJ, Bick AG, Niroula A, Jaiswal S, Ebert BL, Natarajan P, Honigberg MC. J Am Heart Assoc. 2023 Jul 4;12(13):e030220. PMID: 37345823.
H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia. Deng J, Zhao HJ, Zhong Y, Hu C, Meng J, Wang C, Lan X, Wang X, Chen ZJ, Yan J, Wang W, Li Y. EBioMedicine. 2023 Jul;93:104664. PMID: 37331163.
Clonal hematopoiesis is associated with protection from Alzheimer’s disease. Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT Jr, Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S. Nat Med. 2023 Jul;29(7):1662-1670. PMID: 37322115.
Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program. Klarin D, Devineni P, Sendamarai AK, Angueira AR, Graham SE, Shen YH, Levin MG, Pirruccello JP, Surakka I, Karnam PR, Roychowdhury T, Li Y, Wang M, Aragam KG, Paruchuri K, Zuber V, Shakt GE, Tsao NL, Judy RL, Vy HMT, Verma SS, Rader DJ, Do R, Bavaria JE, Nadkarni GN, Ritchie MD; VA Million Veteran Program; Burgess S, Guo DC, Ellinor PT, LeMaire SA, Milewicz DM, Willer CJ, Natarajan P, Tsao PS, Pyarajan S, Damrauer SM. Nat Genet. 2023 Jul;55(7):1106-1115. PMID: 37308786.
Wall shear rate and energy loss coefficient measures using conventional Doppler ultrasound do not predict carotid plaque progression. Goudot G, Bellomo TR, Gaston B, Pauly M, Patel S, Manchester S, Dua A. Vasa. 2023 Jul;52(4):249-256. PMID: 37128732.
Single breath-hold CINE imaging with combined simultaneous multislice and region-optimized virtual coils. Kim D, Coll-Font J, Lobos RA, Stäb D, Pang J, Foster A, Garrett T, Bi X, Speier P, Haldar JP, Nguyen C. Magn Reson Med. 2023 Jul;90(1):222-230. PMID: 36864561.
Application of artificial intelligence in the diagnosis of sleep apnea. Bazoukis G, Bollepalli SC, Chung CT, Li X, Tse G, Bartley BL, Batool-Anwar S, Quan SF, Armoundas AA. J Clin Sleep Med. 2023 Jul 1;19(7):1337-1363. PMID: 36856067. Review.
Multiple Prior Live Births Are Associated With Cardiac Remodeling and Heart Failure Risk in Women. Sarma AA, Paniagua SM, Lau ES, Wang D, Liu EE, Larson MG, Hamburg NM, Mitchell GF, Kizer J, Psaty BM, Allen NB, Lely AT, Gansevoort RT, Rosenberg E, Mukamal K, Benjamin EJ, Vasan RS, Cheng S, Levy D, Boer RA, Gottdiener JS, Shah SJ, Ho JE. J Card Fail. 2023 Jul;29(7):1032-1042. PMID: 36638956.
Beyond cardiomyocytes: Cellular diversity in the heart’s response to exercise. Trager LE, Lyons M, Kuznetsov A, Sheffield C, Roh K, Freeman R, Rhee J, Guseh JS, Li H, Rosenzweig A. J Sport Health Sci. 2023 Jul;12(4):423-437. PMID: 36549585. Review.
Screening for undiagnosed atrial fibrillation using a single-lead electrocardiogram at primary care visits: patient uptake and practitioner perspectives from the VITAL-AF trial. Atlas SJ, Ashburner JM, Chang Y, Borowsky LH, Ellinor PT, McManus DD, Lubitz SA, Singer DE. BMC Prim Care. 2023 Jun 30;24(1):135. PMID: 37391738. Clinical Trial.
Integrative metabolomics differentiate coronary artery disease, peripheral artery disease, and venous thromboembolism risks. Lee J, Gilliland T, Koyama S, Nakao T, Dron J, Lannery K, Wong M, Peloso GM, Hornsby W, Natarajan P. medRxiv [Preprint]. 2023 Jun 27:2023.06.21.23291103. PMID: 37425786.
Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study. Wang Y, Selvaraj MS, Li X, Li Z, Holdcraft JA, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Cade BE, Carlson JC, Carson AP, Chen YI, Curran JE, de Vries PS, Dutcher SK, Ellinor PT, Floyd JS, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, Guo X, He J, Heard-Costa N, Hildalgo B, Hou L, Irvin MR, Joehanes R, Kaplan RC, Kardia SL, Kelly TN, Kim R, Kooperberg C, Kral BG, Levy D, Li C, Liu C, Lloyd-Jone D, Loos RJ, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Murabito JM, Naseri T, O’Connell JR, Palmer ND, Preuss MH, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Ruepena MS, Sheu WH, Smith JA, Smith A, Tiwari HK, Tsai MY, Viaud-Martinez KA, Wang Z, Yanek LR, Zhao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Rotter JI, Lin X, Natarajan P, Peloso GM. medRxiv [Preprint]. 2023 Jun 29:2023.06.28.23291966. PMID: 37425772.
Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation. Pluimer BR, Harrison DL, Boonyavairoje C, Prinssen EP, Rogers-Evans M, Peterson RT, Thyme SB, Nath AK. iScience. 2023 Jun 14;26(7):107099. PMID: 37416451.
IL-6 helps weave the inflammatory web during acute coronary syndromes. Nakao T, Libby P. J Clin Invest. 2023 Jun 1;133(11):e167670. PMID: 37259918.
Periprocedural Mortality in Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO Registry. Simsek B, Rempakos A, Kostantinis S, Karacsonyi J, Gorgulu S, Alaswad K, Choi JW, Jaffer FA, Doshi D, Poommipanit P, Aygul N, Krestyaninov O, Khelimskii D, Uretsky B, Davies R, Goktekin O, ElGuindy A, Jefferson BK, Patel TN, Patel M, Sheikh A, Karmpaliotis D, Potluri S, Al-Azizi K, Mastrodemos OC, Rangan BV, Allana SS, Sandoval Y, Burke MN, Brilakis ES. Circ Cardiovasc Interv. 2023 Jun;16(6):e012977. PMID: 37259859.
Transfer learning enables predictions in network biology. Theodoris CV, Xiao L, Chopra A, Chaffin MD, Al Sayed ZR, Hill MC, Mantineo H, Brydon EM, Zeng Z, Liu XS, Ellinor PT. Nature. 2023 Jun;618(7965):616-624. PMID: 37258680.
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation. Adlam D, Berrandou TE, Georges A, Nelson CP, Giannoulatou E, Henry J, Ma L, Blencowe M, Turley TN, Yang ML, Chopade S, Finan C, Braund PS, Sadeg-Sayoud I, Iismaa SE, Kosel ML, Zhou X, Hamby SE, Cheng J, Liu L, Tarr I, Muller DWM, d’Escamard V, King A, Brunham LR, Baranowska-Clarke AA, Debette S, Amouyel P, Olin JW, Patil S, Hesselson SE, Junday K, Kanoni S, Aragam KG, Butterworth AS; CARDIoGRAMPlusC4D; MEGASTROKE; International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group; Tweet MS, Gulati R, Combaret N; DISCO register; Kadian-Dodov D, Kalman JM, Fatkin D, Hingorani AD, Saw J, Webb TR, Hayes SN, Yang X, Ganesh SK, Olson TM, Kovacic JC, Graham RM, Samani NJ, Bouatia-Naji N. Nat Genet. 2023 Jun;55(6):964-972. PMID: 37248441.
Polygenic prediction of preeclampsia and gestational hypertension. Honigberg MC, Truong B, Khan RR, Xiao B, Bhatta L, Vy HMT, Guerrero RF, Schuermans A, Selvaraj MS, Patel AP, Koyama S, Cho SMJ, Vellarikkal SK, Trinder M, Urbut SM, Gray KJ, Brumpton BM, Patil S, Zöllner S, Antopia MC, Saxena R, Nadkarni GN, Do R, Yan Q, Pe’er I, Verma SS, Gupta RM, Haas DM, Martin HC, van Heel DA, Laisk T, Natarajan P. Nat Med. 2023 Jun;29(6):1540-1549. PMID: 37248299.
Pacing-induced cardiomyopathy after leadless pacemaker implant: It’s all about location, location, location. Pipilas D, Frankel DS, Khurshid S. J Cardiovasc Electrophysiol. 2023 Jun;34(6):1427-1430. PMID: 37245077.
Frequent questions and responses on the 2022 lipoprotein(a) consensus statement of the European Atherosclerosis Society. Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky ML, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard BG, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JK, Ray KK, Tokgözoğlu LS, Catapano AL. Atherosclerosis. 2023 Jun;374:107-120. PMID: 37188555. Review.
Determination of optimal tip position of peripherally inserted central catheters using electrocardiography: a retrospective study. Jung KT, Kelly L, Kuznetsov A, Sabouri AS, Lee K. Korean J Anesthesiol. 2023 Jun;76(3):242-251. PMID: 36550778.
Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk. Kojima S, Koyama S, Ka M, Saito Y, Parrish EH, Endo M, Takata S, Mizukoshi M, Hikino K, Takeda A, Gelinas AF, Heaton SM, Koide R, Kamada AJ, Noguchi M, Hamada M; Biobank Japan Project Consortium; Kamatani Y, Murakawa Y, Ishigaki K, Nakamura Y, Ito K, Terao C, Momozawa Y, Parrish NF. Nat Genet. 2023 Jun;55(6):939-951. PMID: 37169872.
Procedural Time and Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention. Rempakos A, Kostantinis S, Simsek B, Karacsonyi J, Choi JW, Poommipanit P, Khatri JJ, Jaber W, Rinfret S, Nicholson W, Gorgulu S, Jaffer FA, Chandwaney R, Ybarra LF, Bagur R, Alaswad K, Krestyaninov O, Khelimskii D, Karmpaliotis D, Uretsky BF, Soylu K, Yildirim U, Potluri S, Al-Azizi KM, Rangan BV, Mastrodemos OC, Allana S, Sandoval Y, Burke MN, Brilakis ES. Am J Cardiol. 2023 Jun 15;197:55-64. PMID: 37156067.
Obesity-induced inflammation exacerbates clonal hematopoiesis. Pasupuleti SK, Ramdas B, Burns SS, Palam LR, Kanumuri R, Kumar R, Pandhiri TR, Dave UP, Yellapu NK, Zhou X, Zhang C, Sandusky GE, Yu Z, Honigberg MC, Bick AG, Griffin GK, Niroula A, Ebert BL, Paczesny S, Natarajan P, Kapur R. J Clin Invest. 2023 Jun 1;133(11):e163968. PMID: 37071471
Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery. Yurista SR, Chen S, Eder RA, Garrett T, Butsch WS, Aminian A, Tang WHW, Farrar CT, Gee D, Abel ED, Das S, Nguyen CT. Obes Surg. 2023 Jun;33(6):1944-1948. PMID: 37058265.
Prediction of risk for myeloid malignancy in clonal hematopoiesis. Weeks LD, Niroula A, Neuberg D, Wong W, Lindsley RC, Luskin M, Berliner N, Stone RM, DeAngelo DJ, Soiffer R, Uddin MM, Griffin G, Vlasschaert C, Gibson CJ, Jaiswal S, Bick AG, Malcovati L, Natarajan P, Ebert BL. NEJM Evid. 2023 May;2(5):10.1056/evidoa2200310. PMID: 37483562.
Exomap1 mouse: a transgenic model for in vivo studies of exosome biology. Fordjour FK, Abuelreich S, Hong X, Chatterjee E, Lallai V, Ng M, Saftics A, Deng F, Carnel-Amar N, Wakimoto H, Shimizu K, Bautista M, Phu TA, Vu NK, Geiger PC, Raffai RL, Fowler CD, Das S, Christenson LK, Jovanovic-Talisman T, Gould SJ. bioRxiv [Preprint]. 2023 May 29:2023.05.29.542707. PMID: 37398219.
An AAV capsid increases transduction of striatum and a ChAT promoter allows selective cholinergic neuron transduction. Santoscoy MC, Espinoza P, De La Cruz D, Mahamdeh M, Starr JR, Patel N, Maguire CA. Mol Ther Methods Clin Dev. 2023 May 9;29:532-540. PMID: 37359416.
Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes. Zekavat SM, Jorshery SD, Shweikh Y, Horn K, Rauscher FG, Sekimitsu S, Kayoma S, Ye Y, Raghu V, Zhao H, Ghassemi M, Elze T, Segrè AV, Wiggs JL, Scholz M, Priore LD, Wang JC, Natarajan P, Zebardast N. medRxiv [Preprint]. 2023 May 17:2023.05.16.23290063. PMID: 37292770.
Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy. Luciani M, Montalbano M, Troncone L, Bacchin C, Uchida K, Daniele G, Jacobs Wolf B, Butler HM, Kiel J, Berto S, Gensemer C, Moore K, Morningstar J, Diteepeng T, Albayram O, Abisambra JF, Norris RA, Di Salvo TG, Prosser B, Kayed R, Del Monte F. Eur Heart J. 2023 May 1;44(17):1560-1570. PMID: 37122097.
Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2. Giannetti F, Barbieri M, Shiti A, Casini S, Sager PT, Das S, Pradhananga S, Srinivasan D, Nimani S, Alerni N, Louradour J, Mura M, Gnecchi M, Brink P, Zehender M, Koren G, Zaza A, Crotti L, Wilde AAM, Schwartz PJ, Remme CA, Gepstein L, Sala L, Odening KE. Europace. 2023 May 19;25(5):euad094. PMID: 37099628.
Genetics of myocardial interstitial fibrosis in the human heart and association with disease. Nauffal V, Di Achille P, Klarqvist MDR, Cunningham JW, Hill MC, Pirruccello JP, Weng LC, Morrill VN, Choi SH, Khurshid S, Friedman SF, Nekoui M, Roselli C, Ng K, Philippakis AA, Batra P, Ellinor PT, Lubitz SA. Nat Genet. 2023 May;55(5):777-786. PMID: 37081215.
Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration. Rämö JT, Abner E, van Dijk EHC, Wang X, Brinks J, Nikopensius T, Nõukas M, Marjonen H, Silander K, Jukarainen S, Kiiskinen T, Choi SH, Kajanne R, Mehtonen J, Palta P, Lubitz SA, Kaarniranta K, Sobrin L, Kurki M, Yzer S, Ellinor PT, Esko T, Daly MJ, den Hollander AI, Palotie A, Turunen JA, Boon CJF, Rossin EJ; FinnGen Study; Estonian Biobank Research Team. JAMA Ophthalmol. 2023 May 1;141(5):449-457. PMID: 37079300.
The Use of Artificial Intelligence to Predict the Development of Atrial Fibrillation. Pipilas D, Friedman SF, Khurshid S. Curr Cardiol Rep. 2023 May;25(5):381-389. PMID: 37000332. Review.
Outcomes of Early Rhythm Control Therapy in Patients With Atrial Fibrillation and a High Comorbidity Burden in Large Real-World Cohorts. Dickow J, Kany S, Roth Cardoso V, Ellinor PT, Gkoutos GV, Van Houten HK, Kirchhof P, Metzner A, Noseworthy PA, Yao X, Rillig A. Circ Arrhythm Electrophysiol. 2023 May;16(5):e011585. PMID: 36942567
Multipolar Ablation Using Mapping Electrodes: A Novel Approach to Intramural Arrhythmia Substrates. Fernandes GC, Nguyen T, Creed E, Lee K, Jung K, Hack B, Hucker W, Hanley A. JACC Clin Electrophysiol. 2023 May;9(5):680-685. PMID: 36752474. Review.
Accelerated and quantitative three-dimensional molecular MRI using a generative adversarial network. Weigand-Whittier J, Sedykh M, Herz K, Coll-Font J, Foster AN, Gerstner ER, Nguyen C, Zaiss M, Farrar CT, Perlman O. Magn Reson Med. 2023 May;89(5):1901-1914. PMID: 36585915.
A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets. Vlasschaert C, Mack T, Heimlich JB, Niroula A, Uddin MM, Weinstock J, Sharber B, Silver AJ, Xu Y, Savona M, Gibson C, Lanktree MB, Rauh MJ, Ebert BL, Natarajan P, Jaiswal S, Bick AG. Blood. 2023 May 4;141(18):2214-2223. PMID: 36652671.
Plasma protein and venous thromboembolism: prospective cohort and mendelian randomisation analyses. Yuan S, Titova OE, Zhang K, Gou W, Schillemans T, Natarajan P, Chen J, Li X, Åkesson A, Bruzelius M, Klarin D, Damrauer SM, Larsson SC. Br J Haematol. 2023 May;201(4):783-792. PMID: 36734038.
Adjusting for common variant polygenic scores improves yield in rare variant association analyses. Jurgens SJ, Pirruccello JP, Choi SH, Morrill VN, Chaffin M, Lubitz SA, Lunetta KL, Ellinor PT. Nat Genet. 2023 Apr;55(4):544-548. PMID: 36959364.
Atrial Fibrillation in Patients With Cancer: A Persistent and Increasing Challenge. Suero-Abreu GA, Ellinor PT. JACC CardioOncol. 2023 Apr 18;5(2):230-232.PMID: 37144117.
The genetic determinants of recurrent somatic mutations in 43,693 blood genomes. Weinstock JS, Laurie CA, Broome JG, Taylor KD, Guo X, Shuldiner AR, O’Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Redline S, Cade BE, Gilliland FD, Chen Z, Gauderman WJ, Kumar R, Grammer L, Schleimer RP, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Weiss ST, Lasky-Su J, DeMeo DL, Palmer ND, Freedman BI, Bowden DW, Cho MH, Vasan RS, Johnson AD, Yanek LR, Becker LC, Kardia S, He J, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Manichaikul AW, Konkle BA, Johnsen JM, Wheeler MM, Custer BS, Duggirala R, Curran JE, Blangero J, Gui H, Xiao S, Williams LK, Meyers DA, Li X, Ortega V, McGarvey S, Gu CC, Chen YI, Lee WJ, Shoemaker MB, Darbar D, Roden D, Albert C, Kooperberg C, Desai P, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Mathias R, Natarajan P, Jaiswal S, Reiner AP, Bick AG; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Sci Adv. 2023 Apr 28;9(17):eabm4945. PMID: 37126548.
A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([¹⁸F]GE-180) PET/MRI. Kim SJW, Lupo JM, Chen Y, Pampaloni MH, VanBrocklin HF, Narvid J, Kim H, Seo Y. Front Med (Lausanne). 2023 Apr 5;10:1091463. PMID: 37089589.
Multimodal charting of molecular and functional cell states via in situ electro-sequencing. Li Q, Lin Z, Liu R, Tang X, Huang J, He Y, Sui X, Tian W, Shen H, Zhou H, Sheng H, Shi H, Xiao L, Wang X, Liu J. Cell. 2023 Apr 27;186(9):2002-2017.e21. PMID: 37080201.
Clonal haematopoiesis and risk of chronic liver disease. Wong WJ, Emdin C, Bick AG, Zekavat SM, Niroula A, Pirruccello JP, Dichtel L, Griffin G, Uddin MM, Gibson CJ, Kovalcik V, Lin AE, McConkey ME, Vromman A, Sellar RS, Kim PG, Agrawal M, Weinstock J, Long MT, Yu B, Banerjee R, Nicholls RC, Dennis A, Kelly M, Loh PR, McCarroll S, Boerwinkle E, Vasan RS, Jaiswal S, Johnson AD, Chung RT, Corey K, Levy D, Ballantyne C; NHLBI TOPMed Hematology Working Group; Ebert BL, Natarajan P. Nature. 2023 Apr;616(7958):747-754. PMID: 37046084.
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. Weinstock JS, Gopakumar J, Burugula BB, Uddin MM, Jahn N, Belk JA, Bouzid H, Daniel B, Miao Z, Ly N, Mack TM, Luna SE, Prothro KP, Mitchell SR, Laurie CA, Broome JG, Taylor KD, Guo X, Sinner MF, von Falkenhausen AS, Kääb S, Shuldiner AR, O’Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Hou L, Lloyd-Jones DM, Redline S, Cade BE, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Palmer ND, Freedman BI, Bowden DW, Cho MH, DeMeo DL, Vasan RS, Yanek LR, Becker LC, Kardia SLR, Peyser PA, He J, Rienstra M, Van der Harst P, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Cutler MJ, Knight S, Muhlestein JB, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Tracy RP, Konkle BA, Johnsen JM, Wheeler MM, Smith JG, Melander O, Nilsson PM, Custer BS, Duggirala R, Curran JE, Blangero J, McGarvey S, Williams LK, Xiao S, Yang M, Gu CC, Chen YI, Lee WJ, Marcus GM, Kane JP, Pullinger CR, Shoemaker MB, Darbar D, Roden DM, Albert C, Kooperberg C, Zhou Y, Manson JE, Desai P, Johnson AD, Mathias RA; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Blackwell TW, Abecasis GR, Smith AV, Kang HM, Satpathy AT, Natarajan P, Kitzman JO, Whitsel EA, Reiner AP, Bick AG, Jaiswal S. Nature. 2023 Apr;616(7958):755-763. PMID: 37046083.
Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease. Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Sencicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2214997120. PMID: 37043537.
Contrast-Enhanced Cardiac Magnetic Resonance Imaging With a Manganese-Based Alternative to Gadolinium for Tissue Characterization of Acute Myocardial Infarction. Bonner BP, Yurista SR, Coll-Font J, Chen S, Eder RA, Foster AN, Nguyen KD, Caravan P, Gale EM, Nguyen C. J Am Heart Assoc. 2023 Apr 18;12(8):e026923. PMID: 37042259.
Accounting for blood attenuation in intravascular near-infrared fluorescence-ultrasound imaging using a fluorophore-coated guidewire. Rauschendorfer P, Wissmeyer G, Jaffer FA, Gorpas D, Ntziachristos V. J Biomed Opt. 2023 Apr;28(4):046001. PMID: 37035030.
The Genetic Determinants of Aortic Distention. Pirruccello JP, Rämö JT, Choi SH, Chaffin MD, Kany S, Nekoui M, Chou EL, Jurgens SJ, Friedman SF, Juric D, Stone JR, Batra P, Ng K, Philippakis AA, Lindsay ME, Ellinor PT. J Am Coll Cardiol. 2023 Apr 11;81(14):1320-1335. PMID: 37019578.
Association of Initial and Longitudinal Changes in C-reactive Protein With the Risk of Cardiovascular Disease, Cancer, and Mortality. Suthahar N, Wang D, Aboumsallem JP, Shi C, de Wit S, Liu EE, Lau ES, Bakker SJL, Gansevoort RT, van der Vegt B, Jovani M, Kreger BE, Lee Splansky G, Benjamin EJ, Vasan RS, Larson MG, Levy D, Ho JE, de Boer RA. Mayo Clin Proc. 2023 Apr;98(4):549-558. PMID: 37019514.
FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells. Wong D, Auguste G, Lino Cardenas CL, Turner AW, Chen Y, Song Y, Ma L, Perry RN, Aherrahrou R, Kuppusamy M, Yang C, Mosquera JV, Dube CJ, Khan MD, Palmore M, Kalra J, Kavousi M, Peyser PA, Matic L, Hedin U, Manichaikul A, Sonkusare SK, Civelek M, Kovacic JC, Björkegren JLM, Malhotra R, Miller CL. Circ Res. 2023 Apr 28;132(9):1144-1161. PMID: 37017084.
Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling. Kurz FT, Aon MA, Schlemmer HP, Jende JME, O’Rourke B, Armoundas AA. Biophys J. 2023 Apr 18;122(8):1459-1469. PMID: 36905121.
Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention After a Previous Failed Attempt. Rempakos A, Kostantinis S, Simsek B, Karacsonyi J, Choi JW, Poommipanit P, Khatri JJ, Jaber W, Rinfret S, Nicholson W, Gorgulu S, Jaffer FA, Chandwaney R, Ybarra LF, Bagur R, Alaswad K, Krestyaninov O, Khelimskii D, Karmpaliotis D, Uretsky BF, Soylu K, Yildirim U, Potluri S, Rangan BV, Mastrodemos OC, Allana S, Sandoval Y, Burke NM, Brilakis ES. Am J Cardiol. 2023 Apr 15;193:61-69. PMID: 36871531.
Persistent Iron Deficiency and Dysregulated Hepcidin Levels After Durable Left Ventricular Assist Device Therapy. Ton VK, Drezek K, Boerboom S, Ostrom KF, Birchenough C, Camuso J, Logan T, Milley K, Anthony A, Thomas SS, Coglianese E, D’Alessandro DD, Malhotra R, Lewis GD. ASAIO J. 2023 Apr 1;69(4):e152-e154. PMID: 36084293.
Effects of Mavacamten on Measures of Cardiopulmonary Exercise Testing Beyond Peak Oxygen Consumption: A Secondary Analysis of the EXPLORER-HCM Randomized Trial. Wheeler MT, Olivotto I, Elliott PM, Saberi S, Owens AT, Maurer MS, Masri A, Sehnert AJ, Edelberg JM, Chen YM, Florea V, Malhotra R, Wang A, Oreziak A, Myers J. JAMA Cardiol. 2023 Mar 1;8(3):240-247. PMID: 36652223. PMC9857843.
Prevalence and Therapeutic Implications of Clonal Hematopoiesis of Indeterminate Potential in Young Patients With Stroke. Mayerhofer E, Strecker C, Becker H, Georgakis MK, Uddin MM, Hoffmann MM, Nadarajah N, Meggendorfer M, Haferlach T, Rosand J, Natarajan P, Anderson CD, Harloff A, Hoermann G. Stroke. 2023 Apr;54(4):938-946. PMID: 36789775.
Reply. Zekavat SM, Sekimitsu S, Doroodgar Jorshery S, Natarajan P, Rossin EJ, Del Priore L, Zebardast N, Wang JC. Ophthalmology. 2023 Apr;130(4):e15-e16. PMID: 36707304
Identification and Management of Atherosclerotic Cardiovascular Disease Risk in South Asian Populations in the U.S. Agarwala A, Satish P, Rifai MA, Mehta A, Cainzos-Achirica M, Shah NS, Kanaya AM, Sharma GV, Dixon DL, Blumenthal RS, Natarajan P, Nasir K, Virani SS, Patel J. JACC Adv. 2023 Mar;2(2):100258. PMID: 38089916.
Looking into the mirror: Pulmonary vein isolation in a patient with dextrocardia, complete situs inversus, and interrupted inferior vena cava. Khurshid S, Nguyen T, Yamada K, Hanley A. HeartRhythm Case Rep. 2023 Mar 29;9(6):396-400. PMID: 37361983.
Identification and Management of Atherosclerotic Cardiovascular Disease Risk in South Asian Populations in the U.S. Agarwala A, Satish P, Rifai MA, Mehta A, Cainzos-Achirica M, Shah NS, Kanaya AM, Sharma GV, Dixon DL, Blumenthal RS, Natarajan P, Nasir K, Virani SS, Patel J. JACC Adv. 2023 Mar;2(2):100258. PMID: 38089916.
Artificial intelligence-enabled classification of hypertrophic heart diseases using electrocardiograms. Haimovich JS, Diamant N, Khurshid S, Di Achille P, Reeder C, Friedman S, Singh P, Spurlock W, Ellinor PT, Philippakis A, Batra P, Ho JE, Lubitz SA. Cardiovasc Digit Health J. 2023 Mar 7;4(2):48-59. PMID: 37101945.
A Mouse Model of Atrial Fibrillation in Sepsis. Bapat A, Schloss MJ, Yamazoe M, Grune J, Hulsmans M, Milan DJ, Nahrendorf M, Ellinor PT. Circulation. 2023 Mar 28;147(13):1047-1049. PMID: 36972346.
How often is occult atrial fibrillation in cryptogenic stroke causal vs. incidental? A meta-analysis. Chaisinanunkul N, Khurshid S, Buck BH, Rabinstein AA, Anderson CD, Hill MD, Fugate JE, Saver JL. Front Neurol. 2023 Mar 14;14:1103664. PMID: 36998779.
Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass. Khurshid S, Lazarte J, Pirruccello JP, Weng LC, Choi SH, Hall AW, Wang X, Friedman SF, Nauffal V, Biddinger KJ, Aragam KG, Batra P, Ho JE, Philippakis AA, Ellinor PT, Lubitz SA. Nat Commun. 2023 Mar 21;14(1):1558. PMID: 36944631.
Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases. Truong B, Hull LE, Ruan Y, Huang QQ, Hornsby W, Martin H, van Heel DA, Wang Y, Martin AR, Lee SH, Natarajan P. medRxiv [Preprint]. 2023 Mar 23:2023.02.21.23286110. PMID: 36865265.
Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program. Small AM, Peloso GM, Linefsky J, Aragam J, Galloway A, Tanukonda V, Wang LC, Yu Z, Sunitha Selvaraj M, Farber-Eger EH, Baker MT, Setia-Verma S, Lee SSK, Preuss M, Ritchie MD, Damrauer SM, Rader DJ, Wells QS, Loos R, Lubitz SA, Thanassoulis G, Cho K, Wilson PWF; VA Million Veteran Program; Natarajan P, O’Donnell CJ. Circulation. 2023 Mar 21;147(12):942-955. PMID: 36802703.
Systolic Blood Pressure and Cardiovascular Risk: Straightening the Evidence. McCarthy CP, Natarajan P. Hypertension. 2023 Mar;80(3):577-579. PMID: 36791225.
Clonal Hematopoiesis and Risk of Incident Lung Cancer. Tian R, Wiley B, Liu J, Zong X, Truong B, Zhao S, Uddin MM, Niroula A, Miller CA, Mukherjee S, Heiden BT, Luo J, Puri V, Kozower BD, Walter MJ, Ding L, Link DC, Amos CI, Ebert BL, Govindan R, Natarajan P, Bolton KL, Cao Y. J Clin Oncol. 2023 Mar 1;41(7):1423-1433. PMID: 36480766.
Impact of lesion length on the outcomes of chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS-CTO registry. Rempakos A, Simsek B, Kostantinis S, Karacsonyi J, Choi JW, Poommipanit P, Khatri JJ, Jaber W, Rinfret S, Nicholson W, Gorgulu S, Jaffer FA, Chandwaney R, Koutouzis M, Tsiafoutis I, Alaswad K, Krestyaninov O, Khelimskii D, Karmpaliotis D, Uretsky BF, Patel MP, Mahmud E, Potluri S, Rangan BV, Mastrodemos OC, Allana S, Sandoval Y, Burke NM, Brilakis ES. Catheter Cardiovasc Interv. 2023 Mar;101(4):747-755. PMID: 36740236.
Siblings with profound connective tissue disease: First report of biallelic TGFBR1-related Loeys-Dietz syndrome. Starr LJ, Lindsay ME, Lino Cardenas CL, Yetman AT. Am J Med Genet A. 2023 Mar;191(3):786-793. PMID: 36584339.
A seed sequence variant in miR-145-5p causes multisystem smooth muscle dysfunction syndrome. Lino Cardenas CL, Briere LC, Sweetser DA, Lindsay ME, Musolino PL. J Clin Invest. 2023 Mar 1;133(5):e166497. PMID: 36649075.
Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity. Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E. Eur Heart J. 2023 Mar 7;44(10):885-898. PMID: 36660854.
Cardioprotective Effects of a Selective c-Jun N-terminal Kinase Inhibitor in a Rat Model of Myocardial Infarction. Plotnikov MB, Chernysheva GA, Smol’yakova VI, Aliev OI, Fomina TI, Sandrikina LA, Sukhodolo IV, Ivanova VV, Osipenko AN, Anfinogenova ND, Khlebnikov AI, Atochin DN, Schepetkin IA, Quinn MT. Biomedicines. 2023 Feb 27;11(3):714. PMID: 36979693.
SGK1 inhibition attenuated the action potential duration in patient- and genotype-specific re-engineered heart cells with congenital long QT syndrome. Kim M, Das S, Tester DJ, Pradhananga S, Hamrick SK, Gao X, Srinivasan D, Sager PT, Ackerman MJ. Heart Rhythm O2. 2023 Feb 16;4(4):268-274. PMID: 37124559.
The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism. Bressan E, Reed X, Bansal V, Hutchins E, Cobb MM, Webb MG, Alsop E, Grenn FP, Illarionova A, Savytska N, Violich I, Broeer S, Fernandes N, Sivakumar R, Beilina A, Billingsley KJ, Berghausen J, Pantazis CB, Pitz V, Patel D, Daida K, Meechoovet B, Reiman R, Courtright-Lim A, Logemann A, Antone J, Barch M, Kitchen R, Li Y, Dalgard CL; American Genome Center; Rizzu P, Hernandez DG, Hjelm BE, Nalls M, Gibbs JR, Finkbeiner S, Cookson MR, Van Keuren-Jensen K, Craig DW, Singleton AB, Heutink P, Blauwendraat C. Cell Genom. 2023 Feb 6;3(3):100261. PMID: 36950378.
Co-occurring pathogenic variants in 6q27 associated with dementia spectrum disorders in a Peruvian family. Alvarez KLF, Aguilar-Pineda JA, Ortiz-Manrique MM, Paredes-Calderon MF, Cardenas-Quispe BC, Vera-Lopez KJ, Goyzueta-Mamani LD, Chavez-Fumagalli MA, Davila-Del-Carpio G, Peralta-Mestas A, Musolino PL, Lino Cardenas CL. Front Mol Neurosci. 2023 Feb 16;16:1104585. PMID: 36873109.
Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions. Obi AT, Sharma SB, Elfline MA, Luke CE, Dowling AR, Cai Q, Kimball AS, Hollinstat M, Stanger L, Moore BB, Jaffer FA, Henke PK. Sci Rep. 2023 Feb 24;13(1):3253. PMID: 36828892.
Soft robotic patient-specific hydrodynamic model of aortic stenosis and ventricular remodeling. Rosalia L, Ozturk C, Goswami D, Bonnemain J, Wang SX, Bonner B, Weaver JC, Puri R, Kapadia S, Nguyen CT, Roche ET. Sci Robot. 2023 Feb 22;8(75):eade2184. PMID: 36812335.
Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure. Simonson B, Chaffin M, Hill MC, Atwa O, Guedira Y, Bhasin H, Hall AW, Hayat S, Baumgart S, Bedi KC Jr, Margulies KB, Klattenhoff CA, Ellinor PT. Cell Rep. 2023 Feb 28;42(2):112086. PMID: 36790929.
Prevalence and Incidence of Atrial Fibrillation Among Older Primary Care Patients. Khurshid S, Ashburner JM, Ellinor PT, McManus DD, Atlas SJ, Singer DE, Lubitz SA. JAMA Netw Open. 2023 Feb 1;6(2):e2255838. PMID: 36780164.
Use of Mechanical Circulatory Support in Chronic Total Occlusion Percutaneous Coronary Intervention. Karacsonyi J, Deffenbacher K, Benzuly KH, Flaherty JD, Alaswad K, Basir M, Megaly MS, Jaffer F, Doshi D, Poommipanit P, Khatri J, Patel M, Riley R, Sheikh A, Wollmuth JR, Korngold E, Uretsky BF, Yeh RW, Chandwaney RH, Elguindy AM, Tammam K, AbiRafeh N, Schmidt CW, Okeson B, Kostantinis S, Simsek B, Rangan BV, Brilakis ES, Schimmel DR. Am J Cardiol. 2023 Feb 15;189:76-85. PMID: 36512989.
Association of Depression and Poor Mental Health With Cardiovascular Disease and Suboptimal Cardiovascular Health Among Young Adults in the United States. Kwapong YA, Boakye E, Khan SS, Honigberg MC, Martin SS, Oyeka CP, Hays AG, Natarajan P, Mamas MA, Blumenthal RS, Blaha MJ, Sharma G. J Am Heart Assoc. 2023 Feb 7;12(3):e028332. PMID: 36688365.
Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases. Li G, Chen T, Dahlman J, Eniola-Adefeso L, Ghiran IC, Kurre P, Lam WA, Lang JK, Marbán E, Martín P, Momma S, Moos M, Nelson DJ, Raffai RL, Ren X, Sluijter JPG, Stott SL, Vunjak-Novakovic G, Walker ND, Wang Z, Witwer KW, Yang PC, Lundberg MS, Ochocinska MJ, Wong R, Zhou G, Chan SY, Das S, Sundd P. J Extracell Vesicles. 2023 Feb;12(2):e12305. PMID: 36775986. Review.
Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention. Marston NA, Pirruccello JP, Melloni GEM, Koyama S, Kamanu FK, Weng LC, Roselli C, Kamatani Y, Komuro I, Aragam KG, Butterworth AS, Ito K, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT. JAMA Cardiol. 2023 Feb 1;8(2):130-137. PMID: 36576811.
A polygenic score for reduced kidney function and adverse outcomes in a cohort with chronic kidney disease. Steinbrenner I, Yu Z, Jin J, Schultheiss UT, Kotsis F, Grams ME, Coresh J, Wuttke M; GCKD Investigators; Kronenberg F, Eckardt KU, Chatterjee N, Sekula P, Köttgen A. Kidney Int. 2023 Feb;103(2):421-424. PMID: 36481179.
Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic Pathways, Inflammation, and Atherosclerosis. Liu H, Hallauer Hastings M, Kitchen R, Xiao C, Baldovino Guerra JR, Kuznetsov A, Rosenzweig A. Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):330-349. PMID: 36453275.
Sutton NR, Malhotra R, St Hilaire C, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y. Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification. Arterioscler Thromb Vasc Biol. 2023 Jan;43(1):15-29. PMID: 36412195. PMC9793888.
Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection. Liu A, Genovese G, Zhao Y, Pirinen M, Zekavat MM, Kentistou K, Yang Z, Yu K, Vlasschaert C, Liu X, Brown DW, Hudjashov G, Gorman B, Dennis J, Zhou W, Momozawa Y, Pyarajan S, Tuzov V, Pajuste FD, Aavikko M, Sipilä TP, Ghazal A, Huang WY, Freedman N, Song L, Gardner EJ, Sankaran VG, Palotie A, Ollila HM, Tukiainen T, Chanock SJ, Mägi R, Natarajan P, Daly MJ, Bick A, McCarroll SA, Terao C, Loh PR, Ganna A, Perry JRB, Machiela MJ. medRxiv [Preprint]. 2023 Jan 31:2023.01.28.23285140. PMID: 36778285.
Patient-Reported and Clinical Outcomes Among Patients With Calciphylaxis. Wen W, Krinsky S, Kroshinsky D, Durant O, He J, Seethapathy R, Hillien SAS, Mengesha B, Malhotra R, Chitalia V, Nazarian RM, Goverman J, Lyons KS, Nigwekar SU. Mayo Clin Proc Innov Qual Outcomes. 2023 Jan 24;7(1):81-92. PMID: 36712824.
Predicting Arterial Thrombotic Events Following Peripheral Revascularization Using Objective Viscoelastic Data. Majumdar M, Hall RP, Feldman Z, Goudot G, Sumetsky N, Jessula S, Kirshkaln A, Bellomo T, Chang D, Cardenas J, Patell R, Eagleton M, Dua A. J Am Heart Assoc. 2023 Jan 3;12(1):e027790. PMID: 36565191.
Extracellular Non-Coding RNAs in Cardiovascular Diseases. Jiapaer Z, Li C, Yang X, Sun L, Chatterjee E, Zhang L, Lei J, Li G. Pharmaceutics. 2023 Jan 3;15(1):155. PMID: 36678784. Review.
Photobiomodulation and nitric oxide signaling. Kashiwagi S, Morita A, Yokomizo S, Ogawa E, Komai E, Huang PL, Bragin DE, Atochin DN. Nitric Oxide. 2023 Jan 1;130:58-68. PMID: 36462596. Review.
Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank. Vlasschaert C, Heimlich JB, Rauh MJ, Natarajan P, Bick AG. Circulation. 2023 Jan 24;147(4):358-360. PMID: 36689568.
Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies. Li X, Quick C, Zhou H, Gaynor SM, Liu Y, Chen H, Selvaraj MS, Sun R, Dey R, Arnett DK, Bielak LF, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Correa A, Cupples LA, Curran JE, de Vries PS, Duggirala R, Freedman BI, Göring HHH, Guo X, Haessler J, Kalyani RR, Kooperberg C, Kral BG, Lange LA, Manichaikul A, Martin LW, McGarvey ST, Mitchell BD, Montasser ME, Morrison AC, Naseri T, O’Connell JR, Palmer ND, Peyser PA, Psaty BM, Raffield LM, Redline S, Reiner AP, Reupena MS, Rice KM, Rich SS, Sitlani CM, Smith JA, Taylor KD, Vasan RS, Willer CJ, Wilson JG, Yanek LR, Zhao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lipids Working Group; Rotter JI, Natarajan P, Peloso GM, Li Z, Lin X. Nat Genet. 2023 Jan;55(1):154-164. PMID: 36564505.
Polygenic risk scores for prediction of atrial fibrillation. Kavousi M, Ellinor PT. Neth Heart J. 2023 Jan;31(1):1-2. PMID: 36538263.
Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry. Djenoune L, Mahamdeh M, Truong TV, Nguyen CT, Fraser SE, Brueckner M, Howard J, Yuan S. Science. 2023 Jan 6;379(6627):71-78. PMID: 36603098.
TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease. Zekavat SM, Viana-Huete V, Matesanz N, Jorshery SD, Zuriaga MA, Uddin MM, Trinder M, Paruchuri K, Zorita V, Ferrer-Pérez A, Amorós-Pérez M, Kunderfranco P, Carriero R, Greco CM, Aroca-Crevillen A, Hidalgo A, Damrauer SM, Ballantyne CM, Niroula A, Gibson CJ, Pirruccello J, Griffin G, Ebert BL, Libby P, Fuster V, Zhao H, Ghassemi M, Natarajan P, Bick AG, Fuster JJ, Klarin D. Nat Cardiovasc Res. 2023 Jan 16;2:144-158. PMID: 36949957.
Therapeutics of Extracellular Vesicles in Cardiocerebrovascular and Metabolic Diseases. Hou Z, Lin Y, Yang X, Chen J, Li G. Adv Exp Med Biol. 2023;1418:187-205. PMID: 37603281.

2022

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M, Hindy G, Zhou W, Grace C, Roselli C, Marston NA, Kamanu FK, Surakka I, Venegas LM, Sherliker P, Koyama S, Ishigaki K, Åsvold BO, Brown MR, Brumpton B, de Vries PS, Giannakopoulou O, Giardoglou P, Gudbjartsson DF, Güldener U, Haider SMI, Helgadottir A, Ibrahim M, Kastrati A, Kessler T, Kyriakou T, Konopka T, Li L, Ma L, Meitinger T, Mucha S, Munz M, Murgia F, Nielsen JB, Nöthen MM, Pang S, Reinberger T, Schnitzler G, Smedley D, Thorleifsson G, von Scheidt M, Ulirsch JC; Biobank Japan; EPIC-CVD; Arnar DO, Burtt NP, Costanzo MC, Flannick J, Ito K, Jang DK, Kamatani Y, Khera AV, Komuro I, Kullo IJ, Lotta LA, Nelson CP, Roberts R, Thorgeirsson G, Thorsteinsdottir U, Webb TR, Baras A, Björkegren JLM, Boerwinkle E, Dedoussis G, Holm H, Hveem K, Melander O, Morrison AC, Orho-Melander M, Rallidis LS, Ruusalepp A, Sabatine MS, Stefansson K, Zalloua P, Ellinor PT, Farrall M, Danesh J, Ruff CT, Finucane HK, Hopewell JC, Clarke R, Gupta RM, Erdmann J, Samani NJ, Schunkert H, Watkins H, Willer CJ, Deloukas P, Kathiresan S, Butterworth AS; CARDIoGRAMplusC4D Consortium. Nat Genet. 2022 Dec;54(12):1803-1815. PMID: 36474045
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, et al. Genome Biol. 2022 Dec 27;23(1):268. PMID: 36575460.
Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults. Snel GJH, Slart RHJA, Velthuis BK, van den Boomen M, Nguyen CT, Sosnovik DE, van Deursen VM, Dierckx RAJO, Borra RJH, Prakken NHJ. PLoS One. 2022 Dec 1;17(12):e0278308. PMID: 36454872.
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, et al. Genome Biol. 2022 Dec 27;23(1):268. PMID: 36575460.
Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults. Snel GJH, Slart RHJA, Velthuis BK, van den Boomen M, Nguyen CT, Sosnovik DE, van Deursen VM, Dierckx RAJO, Borra RJH, Prakken NHJ. PLoS One. 2022 Dec 1;17(12):e0278308. PMID: 36454872.
Diminished muscle integrity in patients with fibrodysplasia ossificans progressiva assessed with at-home electrical impedance myography. Farid A, Golden E, Robicheau S, Hu A, Cheung K, Yu PB, Rutkove SB, Upadhyay J. Sci Rep. 2022 Dec 3;12(1):20908. PMID: 36463382.
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M, Hindy G, Zhou W, Grace C, Roselli C, Marston NA, Kamanu FK, Surakka I, Venegas LM, Sherliker P, Koyama S, Ishigaki K, Åsvold BO, Brown MR, Brumpton B, de Vries PS, Giannakopoulou O, Giardoglou P, Gudbjartsson DF, Güldener U, Haider SMI, Helgadottir A, Ibrahim M, Kastrati A, Kessler T, Kyriakou T, Konopka T, Li L, Ma L, Meitinger T, Mucha S, Munz M, Murgia F, Nielsen JB, Nöthen MM, Pang S, Reinberger T, Schnitzler G, Smedley D, Thorleifsson G, von Scheidt M, Ulirsch JC; Biobank Japan; EPIC-CVD; Arnar DO, Burtt NP, Costanzo MC, Flannick J, Ito K, Jang DK, Kamatani Y, Khera AV, Komuro I, Kullo IJ, Lotta LA, Nelson CP, Roberts R, Thorgeirsson G, Thorsteinsdottir U, Webb TR, Baras A, Björkegren JLM, Boerwinkle E, Dedoussis G, Holm H, Hveem K, Melander O, Morrison AC, Orho-Melander M, Rallidis LS, Ruusalepp A, Sabatine MS, Stefansson K, Zalloua P, Ellinor PT, Farrall M, Danesh J, Ruff CT, Finucane HK, Hopewell JC, Clarke R, Gupta RM, Erdmann J, Samani NJ, Schunkert H, Watkins H, Willer CJ, Deloukas P, Kathiresan S, Butterworth AS; CARDIoGRAMplusC4D Consortium. Nat Genet. 2022 Dec;54(12):1803-1815. PMID: 36474045.
Pocket CLARITY enables distortion-mitigated cardiac microstructural tissue characterization of large-scale specimens. Kim JJH, Parajuli S, Sinha A, Mahamdeh M, van den Boomen M, Coll-Font J, Chen LS, Fan Y, Eder RA, Phipps K, Yuan S, Nguyen C. Front Cardiovasc Med. 2022 Nov 14;9:1037500. PMID: 36451924.
Editorial: Cardiovascular engineering. Ozturk C, Schmid Daners M, Zhao X, Roche ET, Nguyen CT. Front Cardiovasc Med. 2022 Nov 21;9:1089794. PMID: 36479566.
Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals. Pirruccello JP, Lin H, Khurshid S, Nekoui M, Weng LC, Vasan RS, Isselbacher EM, Benjamin EJ, Lubitz SA, Lindsay ME, Ellinor PT. JAMA. 2022 Nov 15;328(19):1935-1944. PMID: 36378208.
Top2a promotes the development of social behavior via PRC2 and H3K27me3. Geng Y, Zhang T, Alonzo IG, Godar SC, Yates C, Pluimer BR, Harrison DL, Nath AK, Yeh JJ, Drummond IA, Bortolato M, Peterson RT. Sci Adv. 2022 Nov 25;8(47):eabm7069. PMID: 36417527.
Special Issue: Peripheral Factors and Neural Plasticity. van Praag H, Wrann CD. Brain Plast. 2022 Oct 21;8(1):1-3. PMID: 36448037.
Acquired lymphedema: Molecular contributors and future directions for developing intervention strategies. Nurlaila I, Roh K, Yeom CH, Kang H, Lee S. Front Pharmacol. 2022 Oct 25;13:873650. PMID: 36386144. Review.
Understudied factors in drug-coated balloon design and evaluation: A biophysical perspective. Shazly T, Torres WM, Secemsky EA, Chitalia VC, Jaffer FA, Kolachalama VB. Bioeng Transl Med. 2022 Jul 7;8(1):e10370. PMID: 36684110. Review.

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