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  1. CHIP and Atherothrombotic Risk.
    Murphy AJ, Dragoljevic D, Natarajan P, Wang N.
    Thromb Haemost. 2022 Sep;122(9):1435-1442. PMID: 35445383.
  2. Targeting Myocardial Substrate Metabolism in the Failing Heart: Ready for Prime Time?
    Yurista SR, Chen S, Welsh A, Tang WHW, Nguyen CT.
    Curr Heart Fail Rep. 2022 Aug;19(4):180-190. PMID: 35567658. Review.
  3. Aging Related Impairment of Brain Microvascular Bioenergetics Involves Oxidative Phosphorylation and Glycolytic Pathways.
    Sakamuri SS, Sure VN, Kolli L, Evans WR, Sperling JA, Bix GJ, Wang X, Atochin DN, Murfee WL, Mostany R, Katakam PV.
    J Cereb Blood Flow Metab. 2022 Aug;42(8):1410-1424. PMID: 35296173.
  4. Mortality Among Patients With Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes.
    Yoneda ZT, Anderson KC, Ye F, Quintana JA, O’Neill MJ, Sims RA, Sun L, Glazer AM, Davogustto G, El-Harasis M, Laws JL, Saldivar BN, Crawford DM, Stricker T, Wells Q, Darbar D, Michaud GF, Stevenson LW, Lubitz SA, Ellinor PT, Roden DM, Shoemaker MB.
    JAMA Cardiol. 2022 Jul 1;7(7):733-741. PMID: 35544069.
  5. Rare and Common Genetic Variation Underlying the Risk of Hypertrophic Cardiomyopathy in a National Biobank.
    Biddinger KJ, Jurgens SJ, Maamari D, Gaziano L, Choi SH, Morrill VN, Halford JL, Khera AV, Lubitz SA, Ellinor PT, Aragam KG.
    JAMA Cardiol. 2022 Jul 1;7(7):715-722. PMID: 35583889.
  6. Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy with Cardiovascular Disease Outcomes and All-Cause Mortality.
    Patel AP, Dron JS, Wang M, Pirruccello JP, Ng K, Natarajan P, Lebo M, Ellinor PT, Aragam KG, Khera AV.
    JAMA Cardiol. 2022 Jul 1;7(7):723-732. PMID: 35544052.
  7. Zebrafish Models of Cardiac Disease: From Fortuitous Mutants to Precision Medicine.
    González-Rosa JM.
    Circ Res. 2022 Jun 10;130(12):1803-26. PMID: 35679360.
  8. Sex Differences in Temporal Trends of Cardiovascular Health in Young US Adults.
    Cho SMJ, Haidermota S, Honigberg MC, Natarajan P.
    J Am Heart Assoc. 2022 Jun 7;11(11):e024790. PMID: 35652471.
  9. Glycated Hemoglobin as an Integrator of Cardiovascular Risk in Individuals Without Diabetes: Lessons from Recent Epidemiologic Studies.
    Hoffmann AP, Honigberg MC.
    Curr Atheroscler Rep. 2022 Jun;24(6):435-42. PMID: 35386092. Review.
  10. Protocol Paper: A Multi-Center, Double-Blinded, Randomized, 6-Month, Placebo-Controlled Study Followed by 12-Month Open Label Extension to Evaluate the Safety and Efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP).
    Smilde BJ, Stockklausner C, Keen R, Whittaker A, Bullock AN, von Delft A, van Schoor NM, Yu PB, Eekhoff EMW.
    BMC Musculoskelet Disord. 2022 Jun 1;23(1):519. PMID: 35650602.
  11. Integrative Analysis of Circulating Metabolite Levels That Correlate With Physical Activity and Cardiorespiratory Fitness.
    Nayor M, Chernofsky A, Miller PE, Spartano NL, Murthy VL, Malhotra R, Houstis NE, Murabito JM, Clish CB, Larson MG, Vasan RS, Shah RV, Lewis GD.
    Circ Genom Precis Med. 2022 Jun;15(3):e003592. PMID: 35536222.
  12. Distinct Stress-Dependent Signatures of Cellular and Extracellular tRNA-Derived Small RNAs.
    Li G, Manning AC, Bagi A, Yang X, Gokulnath P, Spanos M, Howard J, Chan PP, Sweeney T, Kitchen R, Li H, Laurent BD, Aranki SF, Kontaridis MI, Laurent LC, Van Keuren-Jensen K, Muehlschlegel J, Lowe TM, Das S.
    Adv Sci (Weinh). 2022 Jun;9(17):e2200829. PMID: 35373532.
  13. Genome-Wide and Phenome-Wide Analysis of Ideal Cardiovascular Health in the VA Million Veteran Program.
    Huang RDL, Nguyen XT, Peloso GM, Trinder M, Posner DC, Aragam KG, Ho YL, Lynch JA, Damrauer SM, Chang KM, Tsao PS, Natarajan P, Assimes T, Gaziano JM, Djousse L, Cho K, Wilson PWF, Huffman JE, O’Donnell CJ; Veterans Affairs’ Million Veteran Program.
    PLoS One. 2022 May 25;17(5):e0267900. PMID: 35613103.
  14. Accounting for Population Structure in Genetic Studies of Cystic Fibrosis.
    Kingston H, Stilp AM, Gordon W, Broome J, Gogarten SM, Ling H, Barnard J, Dugan-Perez S, Ellinor PT, Gabriel S, Germer S, Gibbs RA, Gupta N, Rice K, Smith AV, Zody MC; Cystic Fibrosis Genome Project; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Blackman SM, Cutting G, Knowles MR, Zhou YH, Rosenfeld M, Gibson RL, Bamshad M, Fohner A, Blue EE.
    HGG Adv. 2022 May 12;3(3):100117. PMID: 35647563.
  15. The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.
    Wang Z, Choi SW, Chami N, Boerwinkle E, Fornage M, Redline S, Bis JC, Brody JA, Psaty BM, Kim W, McDonald MN, Regan EA, Silverman EK, Liu CT, Vasan RS, Kalyani RR, Mathias RA, Yanek LR, Arnett DK, Justice AE, North KE, Kaplan R, Heckbert SR, de Andrade M, Guo X, Lange LA, Rich SS, Rotter JI, Ellinor PT, Lubitz SA, Blangero J, Shoemaker MB, Darbar D, Gladwin MT, Albert CM, Chasman DI, Jackson RD, Kooperberg C, Reiner AP, O’Reilly PF, Loos RJF.
    Front Endocrinol (Lausanne). 2022 May 3;13:863893. PMID: 35592775.
  16. Resting Heart Rate and Incident Atrial Fibrillation: A Stratified Mendelian Randomization in the AFGen Consortium.
    Siland JE, Geelhoed B, Roselli C, Wang B, Lin HJ, Weiss S, Trompet S, van den Berg ME, Soliman EZ, Chen LY, Ford I, Jukema JW, Macfarlane PW, Kornej J, Lin H, Lunetta KL, Kavousi M, Kors JA, Ikram MA, Guo X, Yao J, Dörr M, Felix SB, Völker U, Sotoodehnia N, Arking DE, Stricker BH, Heckbert SR, Lubitz SA, Benjamin EJ, Alonso A, Ellinor PT, van der Harst P, Rienstra M.
    PLoS One. 2022 May 20;17(5):e0268768. PMID: 35594314.
  17. Longitudinal Profiling of Clonal Hematopoiesis Provides Insight Into Clonal Dynamics.
    Uddin MM, Zhou Y, Bick AG, Burugula BB, Jaiswal S, Desai P, Honigberg MC, Love SA, Barac A, Hayden KM, Manson JE, Whitsel EA, Kooperberg C, Natarajan P, Reiner AP, Kitzman JO.
    Immun Ageing. 2022 May 24;19(1):23. PMID: 35610705.
  18. Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement.
    Salomon C, Das S, Erdbrügger U, Kalluri R, Kiang Lim S, Olefsky JM, Rice GE, Sahoo S, Andy Tao W, Vader P, Wang Q, Weaver AM.
    Endocr Rev. 2022 May 12;43(3):441-68. PMID: 35552682.
  19. Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics.
    Roh JD, Kitchen RR, Guseh JS, McNeill JN, Aid M, Martinot AJ, Yu A, Platt C, Rhee J, Weber B, Trager LE, Hastings MH, Ducat S, Xia P, Castro C, Singh A, Atlason B, Churchill TW, Di Carli MF, Ellinor PT, Barouch DH, Ho JE, Rosenzweig A.
    JACC Basic Transl Sci. 2022 May;7(5):425-41. PMID: 35530264.
  20. Intravenous Sodium Thiosulphate for Vascular Calcification of Hemodialysis Patients – a Systematic Review and Meta-Analysis.
    Wen W, Portales-Castillo I, Seethapathy R, Krinsky S, Kroshinsky D, Kalim S, Goverman J, Nazarian RM, Chitalia V, Malhotra R, Kramann R, Malhotra CK, Nigwekar SU.
    Nephrol Dial Transplant. 2022 May 6:gfac171. PMID: 35521751.
  21. Genetics of Smoking and Risk of Clonal Hematopoiesis
    Levin MG, Nakao T, Zekavat SM, Koyama S, Bick AG, Niroula A, Ebert B, Damrauer SM, Natarajan P.
    Sci Rep. 2022 May 4;12(1):7248. PMID: 35508625.
  22. Genetics of Smoking and Risk of Clonal Hematopoiesis.
    Pulous FE, Cruz-Hernández JC, Yang C, Kaya Ζ, Paccalet A, Wojtkiewicz G, Capen D, Brown D, Wu JW, Schloss MJ, Vinegoni C, Richter D, Yamazoe M, Hulsmans M, Momin N, Grune J, Rohde D, McAlpine CS, Panizzi P, Weissleder R, Kim DE, Swirski FK, Lin CP, Moskowitz MA, Nahrendorf M.
    Nat Neurosci. 2022 May;25(5):567-76. PMID: 35501382.
  23. Association of Cardiometabolic Disease With Cancer in the Community.
    Liu EE, Suthahar N, Paniagua SM, Wang D, Lau ES, Li SX, Jovani M, Takvorian KS, Kreger BE, Benjamin EJ, Meijers WC, Bakker SJL, Kieneker LM, Gruppen EG, van der Vegt B, de Bock GH, Gansevoort RT, Hussain SK, Hoffmann U, Splansky GL, Vasan RS, Larson MG, Levy D, Cheng S, de Boer RA, Ho JE.
    JACC CardioOncol. 2022 Mar 15;4(1):69-81. PMID: 35492825.
  24. Cardiovascular Disease Among Patients With AML and CHIP-Related Mutations.
    Calvillo-Argüelles O, Schoffel A, Capo-Chichi JM, Abdel-Qadir H, Schuh A, Carrillo-Estrada M, Liu S, Gupta V, Schimmer AD, Yee K, Shlush LI, Natarajan P, Thavendiranathan P.
    JACC CardioOncol. 2022 Mar 15;4(1):38-49. PMID: 35492819.
  25. Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart.
    Alenezi F, Covington TA, Mukherjee M, Mathai SC, Yu PB, Rajagopal S.
    Circ Res. 2022 Apr 29;130(9):1445-65. PMID: 35482838. Review.
  26. A Phenome-Wide Association Study of Genes Associated with COVID-19 Severity Reveals Shared Genetics with Complex Diseases in the Million Veteran Program.
    Verma A, Tsao NL, Thomann LO, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford DC, Efird JT, Huffman JE, Hung A, Ivey KL, Levin MG, Lynch J, Natarajan P, Pyarajan S, Bick AG, Costa L, Genovese G, Hauger R, Madduri R, Pathak GA, Polimanti R, Voight B, Vujkovic M, Zekavat SM, Zhao H, Ritchie MD; VA Million Veteran Program COVID-19 Science Initiative, Chang KM, Cho K, Casas JP, Tsao PS, Gaziano JM, O’Donnell C, Damrauer SM, Liao KP.
    PLoS Genet. 2022 Apr 28;18(4):e1010113. PMID: 35482673.
  27. DeepStrain Evidence of Asymptomatic Left Ventricular Diastolic and Systolic Dysfunction in Young Adults With Cardiac Risk Factors.
    Morales MA, Snel GJH, van den Boomen M, Borra RJH, van Deursen VM, Slart RHJA, Izquierdo-Garcia D, Prakken NHJ, Catana C.
    Front Cardiovasc Med. 2022 Apr 11;9:831080. PMID: 35479280.
  28. Sex-Specific Differences in Ventricular Remodeling and Response After Cardiac Resynchronization Therapy.
    Varrias D, De La Hoz MA, Zhao M, Pujol M, Orencole M, Venkata VS, Zordok MA, Luong K, Rana F, Lau E, Ibrahim N, Newton-Cheh C, Heist K, Singh J, Das S.
    Am J Cardiol. 2022 Jul 1;174:68-75. PMID: 35473782.
  29. Monogenic and Polygenic Contributions to QTc Prolongation in the Population.
    Nauffal V, Morrill VN, Jurgens SJ, Choi SH, Hall AW, Weng LC, Halford JL, Austin-Tse C, Haggerty CM, Harris SL, Wong EK, Alonso A, Arking DE, Benjamin EJ, Boerwinkle E, Min YI, Correa A, Fornwalt BK, Heckbert SR; National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium, Kooperberg C, Lin HJ, J F Loos R, Rice KM, Gupta N, Blackwell TW, Mitchell BD, Morrison AC, Psaty BM, Post WS, Redline S, Rehm HL, Rich SS, Rotter JI, Soliman EZ, Sotoodehnia N, Lunetta KL, Ellinor PT, Lubitz SA; TOPMed Investigators.
    Circulation. 2022 May 17;145(20):1524-33. PMID: 35389749.
  30. In Silico Analysis of the Antagonist Effect of Enoxaparin on the ApoE4-Amyloid-Beta (Aβ) Complex at Different pH Conditions.
    Aguilar-Pineda JA, Paco-Coralla SG, Febres-Molina C, Gamero-Begazo PL, Shrivastava P, Vera-López KJ, Davila-Del-Carpio G, López-C P, Gómez B, Lino Cardenas CL.
    Biomolecules. 2022 Mar 25;12(4):499. PMID: 35454088.
  31. Genome-Wide Pleiotropy Analysis of Coronary Artery Disease and Pneumonia Identifies Shared Immune Pathways.
    Yu Z, Zekavat SM, Haidermota S, Bernardo R, MacDonald BT, Libby P, Finucane HK, Natarajan P.
    Sci Adv. 2022 Apr 22;8(16):eabl4602. PMID: 35452290.
  32. Infertility and Risk of Heart Failure in the Women’s Health Initiative.
    Lau ES, Wang D, Roberts M, Taylor CN, Murugappan G, Shadyab AH, Schnatz PF, Farland LV, Wood MJ, Scott NS, Eaton CB, Ho JE.
    J Am Coll Cardiol. 2022 Apr 26;79(16):1594-1603. PMID: 35450577.
  33. Machine Learning Techniques for Arrhythmic Risk Stratification: A Review of the Literature.
    Chung CT, Bazoukis G, Lee S, Liu Y, Liu T, Letsas KP, Armoundas AA, Tse G.
    Int J Arrhythmia. 2022;23:10. PMID: 35449883.
  34. Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement.
    Salomon C, Das S, Erdbrügger U, Kalluri R, Kiang Lim S, Olefsky JM, Rice GE, Sahoo S, Andy Tao W, Vader P, Wang Q, Weaver AM.
    Endocr Rev. 2022 Apr 21:bnac009. PMID: 35446389.
  35. Development of a Clinical Polygenic Risk Score Assay and Reporting Workflow
    Hao L, Kraft P, Berriz GF, Hynes ED, Koch C, Korategere V Kumar P, Parpattedar SS, Steeves M, Yu W, Antwi AA, Brunette CA, Danowski M, Gala MK, Green RC, Jones NE, Lewis ACF, Lubitz SA, Natarajan P, Vassy JL, Lebo MS.
    Nat Med. 2022 May;28(5):1006-13. PMID: 35437332.
  36. Alzheimer’s Disease: A Silent Pandemic – A Systematic Review on the Situation and Patent Landscape of the Diagnosis.
    Goyzueta-Mamani LD, Chávez-Fumagalli MA, Alvarez-Fernandez K, Aguilar-Pineda JA, Nieto-Montesinos R, Davila Del-Carpio G, Vera-Lopez KJ, Lino Cardenas CL.
    Recent Pat Biotechnol. 2022 May;16(4):355-378. PMID: 35400333.
  37. Cohort Design and Natural Language Processing to Reduce Bias in Electronic Health Records Research
    Khurshid S, Reeder C, Harrington LX, Singh P, Sarma G, Friedman SF, Di Achille P, Diamant N, Cunningham JW, Turner AC, Lau ES, Haimovich JS, Al-Alusi MA, Wang X, Klarqvist MDR, Ashburner JM, Diedrich C, Ghadessi M, Mielke J, Eilken HM, McElhinney A, Derix A, Atlas SJ, Ellinor PT, Philippakis AA, Anderson CD, Ho JE, Batra P, Lubitz SA.
    NPJ Digit Med. 2022 Apr 8;5(1):47. PMID: 35396454.
  38. Making a sPLAsh: he Expanding Repertoire of EV Signaling.
    Li G, Das S.
    Cell Metab. 2022 Apr 5;34(4):508-10. PMID: 35385702.
  39. Mendelian Randomization Supports Bidirectional Causality Between Telomere Length and Clonal Hematopoiesis of Indeterminate Potential.
    Nakao T, Bick AG, Taub MA, Zekavat SM, Uddin MM, Niroula A, Carty CL, Lane J, Honigberg MC, Weinstock JS, Pampana A, Gibson CJ, Griffin GK, Clarke SL, Bhattacharya R, Assimes TL, Emery LS, Stilp AM, Wong Q, Broome J, Laurie CA, Khan AT, Smith AV, Blackwell TW, Codd V, Nelson CP, Yoneda ZT, Peralta JM, Bowden DW, Irvin MR, Boorgula M, Zhao W, Yanek LR, Wiggins KL, Hixson JE, Gu CC, Peloso GM, Roden DM, Reupena MS, Hwu CM, DeMeo DL, North KE, Kelly S, Musani SK, Bis JC, Lloyd-Jones DM, Johnsen JM, Preuss M, Tracy RP, Peyser PA, Qiao D, Desai P, Curran JE, Freedman BI, Tiwari HK, Chavan S, Smith JA, Smith NL, Kelly TN, Hidalgo B, Cupples LA, Weeks DE, Hawley NL, Minster RL; Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, Deka R, Naseri TT, de Las Fuentes L, Raffield LM, Morrison AC, Vries PS, Ballantyne CM, Kenny EE, Rich SS, Whitsel EA, Cho MH, Shoemaker MB, Pace BS, Blangero J, Palmer ND, Mitchell BD, Shuldiner AR, Barnes KC, Redline S, Kardia SLR, Abecasis GR, Becker LC, Heckbert SR, He J, Post W, Arnett DK, Vasan RS, Darbar D, Weiss ST, McGarvey ST, de Andrade M, Chen YI, Kaplan RC, Meyers DA, Custer BS, Correa A, Psaty BM, Fornage M, Manson JE, Boerwinkle E, Konkle BA, Loos RJF, Rotter JI, Silverman EK, Kooperberg C, Danesh J, Samani NJ, Jaiswal S, Libby P, Ellinor PT, Pankratz N, Ebert BL, Reiner AP, Mathias RA, Do R; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Natarajan P.
    Sci Adv. 2022 Apr 8;8(14):eabl6579. PMID: 35385311.
  40. Lipoprotein(a), Menopausal Hormone Therapy, and Risk of Coronary Heart Disease in Postmenopausal Individuals.
    Honigberg MC, Trinder M, Natarajan P.
    JAMA Cardiol. 2022 May 1;7(5):565-8. PMID: 35377945.
  41. B Lymphocyte-Derived Acetylcholine Limits Steady-State and Emergency Hematopoiesis.
    Schloss MJ, Hulsmans M, Rohde D, Lee IH, Severe N, Foy BH, Pulous FE, Zhang S, Kokkaliaris KD, Frodermann V, Courties G, Yang C, Iwamoto Y, Knudsen AS, McAlpine CS, Yamazoe M, Schmidt SP, Wojtkiewicz GR, Masson GS, Gustafsson K, Capen D, Brown D, Higgins JM, Scadden DT, Libby P, Swirski FK, Naxerova K, Nahrendorf M.
    Nat Immunol. 2022 Apr;23(4):605-18. PMID: 35352063.
  42. Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease.
    Biddinger KJ, Emdin CA, Haas ME, Wang M, Hindy G, Ellinor PT, Kathiresan S, Khera AV, Aragam KG.
    JAMA Netw Open. 2022 Mar 1;5(3):e223849. PMID: 35333364.
  43. A Novel Tissue Atlas and Online Tool for the Interrogation of Small RNA Expression in Human Tissues and Biofluids.
    Alsop E, Meechoovet B, Kitchen R, Sweeney T, Beach TG, Serrano GE, Hutchins E, Ghiran I, Reiman R, Syring M, Hsieh M, Courtright-Lim A, Valkov N, Whitsett TG, Rakela J, Pockros P, Rozowsky J, Gallego J, Huentelman MJ, Shah R, Nakaji P, Kalani MYS, Laurent L, Das S, Van Keuren-Jensen K.
    Front Cell Dev Biol. 2022 Mar 4;10:804164. PMID: 35317387.
  44. Genetic and Phenotypic Profiling of Supranormal Ejection Fraction Reveals Decreased Survival and Underdiagnosed Heart Failure.
    Forrest IS, Rocheleau G, Bafna S, Argulian E, Narula J, Natarajan P, Do R.
    Eur J Heart Fail. 2022 Mar 12. PMID: 35278270.
  45. Cardiac Alterations on 3T MRI in Young Adults With Sedentary Lifestyle-Related Risk Factors.
    Snel GJH, van den Boomen M, Hurtado-Ortiz K, Slart RHJA, van Deursen VM, Nguyen CT, Sosnovik DE, Dierckx RAJO, Velthuis BK, Borra RJH, Prakken NHJ.
    Front Cardiovasc Med. 2022 Feb 22;9:840790. PMID: 35274012.
  46. Point-of-Care Screening for Atrial Fibrillation: Where Are We, and Where Do We Go Next?
    Ashburner JM, Khurshid S, Atlas SJ, Singer DE, Lubitz SA.
    Cardiovasc Digit Health J. 2021 Oct 8;2(6):294-7. PMID: 35265924.