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2026

Foundation Models for Electrocardiogram Interpretation: Clinical Implications Nolin-Lapalme A, Sowa A, Delfrate J, Tastet O, Corbin D, Kulbay M, Ozdemir D, Noël MJ, Marois-Blanchet FC, Harvey F, Sharma S, Ansari M, Chiu IM, D’souza V, Friedman SF, Chassé M, Potter BJ, Afilalo J, Elias PA, Jabbour G, Bahani M, Dubé MP, Boyle PM, Chatterjee NA, Barrios J, Tison GH, Ouyang D, Maddah M, Khurshid S, Cadrin-Tourigny J, Tadros R, Hussin J, Avram R. Eur Heart J. 2026 May 15;47(18):2174-2186. PMID: 41568699.
Treatment of a Severe Vascular Disease Using a Bespoke CRISPR-Cas9 Base Editor in Mice. Alves CRR, Das S, Krishnan V, Ha LL, Fox LR, Stutzman HE, Shamber CE, Kalailingam P, McCarthy S, Lino Cardenas CL, Fong CE, Imai T, Mitra S, Yun S, Wood RK, Benning FMC, Lawton J, Kim N, Silverstein RA, da Silva JF, de la Cruz D, Richa R, Malhotra R, Chung DY, Chao LH, Tsai SQ, Maguire CA, Lindsay ME, Kleinstiver BP, Musolino PL. Nat Biomed Eng. 2026 May;10(5):952-967. PMID: 40935887.
Aortic and Cardiac Structure From Routine CT Predict Cardiovascular Risk Beyond PREVENT and Coronary Calcium. Oo DW, Jung M, Nürnberg L, Chandra J, Sturniolo A, Kerkovits N, Jorshery SD, Langenbach M, Foldyna B, Kiel DP, Aerts HJWL, Natarajan P, Lu MT, Raghu VK. JACC Cardiovasc Imaging. 2026 May;19(5):621-633. PMID: 41718510.
Free-Breathing Multi-Slice Co-Registered Cardiac T1, T2, and ADC Mapping With Spin-Echo Echo Planar Imaging. Mai D, Kara D, Liu Y, Moura TRS, Sadighi M, Kanj F, Wexler E, Sosnovik D, Hanna M, Santangeli P, Nakagawa H, Wazni O, Chen D, Tang WHW, Tandon A, Kwon D, Nguyen C. Magn Reson Med. 2026 Apr;95(4):2035-2051. PMID: 41240353.
Nephrotic Syndrome Genomic Discovery in the Mass General Brigham Biobank Identifies Monoallelic MEFV Variants as a Risk Factor for Focal Segmental Glomerulosclerosis. Wongboonsin J, Gibson KM, Ke J, Sentell ZT, Arcila-Galvis JE, Koyama S, Greenberg A, Reynolds KM, Montini G, Magistroni R, Mitrotti A, Gesualdo L, Pezzuto A, Peruzzi L, Caliskan Y, Onuchic-Whitford AC, Bunlungsup S, McNulty M, Gbadegesin R, Saleem MA, Pollak MR, Hildebrandt F, Natarajan P, Lee D, Nigwekar SU, Sayer JA, Sanna-Cherchi S, Sampson MG. Kidney Int. 2026 Apr;109(4):750-764. PMID: 41453490.
Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials. Marti-Castellote PM, Badrouchi S, Claggett B, Xu D, Maddah M, Khurshid S, Vardeny O, Lewis EF, Jhund PS, Desai AS, Ellinor PT, Ho JE, McMurray JJV, Pfeffer M, Solomon SD, Cunningham JW. J Am Coll Cardiol. 2026 Apr 21;87(15):1856-1866. PMID: 41493293.
Artificial Intelligence-Enabled ECG Analysis to Predict Incident Heart Failure. Khurshid S, Friedman SF, Kany S, D’Souza V, Roshandelpoor A, Kosyakovsky LB, Chitsazan M, Cunningham JW, Singh P, Lau ES, Pipilas D, Al-Alusi M, Rämö JT, Pirruccello JP, Reeder C, Waks JW, Lubitz SA, Philippakis AA, Maddah M, Ellinor PT, Ho JE. Circ Heart Fail. 2026 Apr;19(4):e013927. PMID: 41730522.
Management and Consequences of Genotype-Positive Familial Hypercholesterolemia. Spinks C, Selvaraj MS, Robinson C, Peloso GM, Gwynne C, Urbut S, Truong B, Paruchuri K, Hornsby W, Natarajan P. JAMA Cardiol. 2026 Apr 1;11(4):378-382. PMID: 41779414.
Genetic Associations With Placental and Pregnancy Proteins in Maternal Serum Identify Biomarkers for Hypertension in Pregnancy. Yan Q, Zhang Y, Blue NR, Truong B, Guerrero RF, Honigberg MC, Parry S, McNeil RB, Simhan HN, Chung J, Mercer BM, Grobman WA, Silver R, Greenland P, Saade GR, Reddy UM, Wapner RJ, Liu N, Haas DM. Am J Obstet Gynecol. 2026 Mar;234(3):779-815. PMID: 41183724.
Enhanced-mRNA Delivery Using Ultrasound-Delivered Anchors for Bioorthogonal Ligation. Di Ianni E, Jeon J, Mohammadi S, Hu H, Quintana JM, Lee C, Haidar EA, Goemans M, Zargani-Piccardi A, Mahamdeh M, Hernández IC, Rodriguez VE, Zhou Y, Aguirre A, Yuan S, Ng TSC, Breyne K, Lee H, Breakefield XO, Miller MA. Angew Chem Int Ed Engl. 2026 Mar 2;65(10):e23437. PMID: 41568620.
Clonal Haematopoiesis and Risk of Incident Rheumatoid Arthritis: Results From the UK Biobank. Cui J, Yu Z, Oakes EG, Truong B, Uddin M, Bick A, Niroula A, Solomon DH, Natarajan P, Costenbader KH. Clin Exp Rheumatol. 2026 Mar 4. PMID: 41779596.
Blood Pressure Polygenic Score Predicts Long-Term Blood Pressure Control and Treatment-Resistant Hypertension. Cho SMJ, Ruan Y, Lee HH, Koyama S, Juraschek SP, Allen NB, Yang E, McEvoy JW, Secemsky EA, Honigberg MC, Fahed AC, Patel AP, Hornsby WE, Natarajan P. Hypertension. 2026 Mar;83(3):e26399. PMID: 41532316.
SAIGE-GPU: Accelerating Genome- and Phenome-Wide Association Studies Using GPUs. Rodriguez A, Kim Y, Nandi TN, Keat K, Kumar R, Conery M, Bhukar R, Liu M, Hessington J, Maheshwari K; VA Million Veteran Program; Begoli E, Tourassi G, Muralidhar S, Natarajan P, Voight BF, Cho K, Gaziano JM, Damrauer SM, Liao KP, Zhou W, Huffman JE, Verma A, Madduri RK. Bioinformatics. 2026 Feb 28;42(3):btag032. PMID: 41572430.
cellSTAAR: Incorporating Single-Cell-Sequencing-Based Functional Data to Boost Power in Rare Variant Association Testing of Noncoding Regions. Van Buren E, Zhang Y, Li X, Selvaraj MS, Li Z, Zhou H, Palmer ND, Arnett DK, Blangero J, Boerwinkle E, Cade BE, Carlson JC, Carson AP, Chen YI, Curran J, Duggirala R, Fornage M, Franceschini N, Graff M, Gu C, Guo X, He J, Heard-Cosa N, Hou L, Hung YJ, Kalyani RR, Kardia SLR, Kenny E, Kooperberg C, Kral BG, Lange L, Levy D, Li C, Liu S, Lloyd-Jones D, Loos RJF, Manichaikul AW, Martin LW, Mathias R, Minster RL, Mitchell BD, Mychaleckyj JC, Naseri T, North K, O’Connell J, Perry JA, Peyser PA, Psaty BM, Raffield LM, Vasan RS, Redline S, Reiner AP, Rich SS, Smith JA, Spitzer B, Tang H, Taylor KD, Tracy R, Viali S, Yanek L, Zhao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Rotter JI, Peloso GM, Natarajan P, Lin X. Nat Methods. 2026 Feb;23(2):338-349. PMID: 41476111.
Diffusion Tensor MRI of the Heart: The Toolbox Continues to Grow. Sosnovik DE, Nguyen CT. Circ Cardiovasc Imaging. 2026 Feb;19(2):e019374. PMID: 41562127.
Loss of Mtarc1 Protects Against Steatotic Liver Disease in Mice. Yin X, Bickerton C, MacDonald B, Arduini A, Shi Y, Haas M, Deik A, Chaffin M, Kovacs-Bogdan E, Pacheco JA, Amegadjie M, Bhandary B, Sadre S, Rathjen T, Papangeli I, Chung RT, Goodman R, Claussnitzer M, Clish C, Ehrmann A, Leed A, Ellinor PT. Liver Int. 2026 Feb;46(2):e70507. PMID: 41527487.
Population-Scale Analysis Reveals Inherited C1-Inhibitor Deficiency Is a Polyphenotypic Thrombotic Disorder. Rodriguez Espada A, Haj AK, Jurgens SJ, Eswaran H, Sundler Björkman L, Ryu J, Chaudhry S, Koyama S, Wang X, Choi SH, Sanna-Cherchi S, Banerji A, Rämö JT, Ellinor PT, Grover SP, Bendapudi PK. Blood Adv. 2026 Feb 10;10(3):931-938. PMID: 41026970.
Timing of Physical Activity and Risk of Future Cardiovascular Disease. Ajufo E, Kany S, Churchill TW, Guseh JS, Ellinor PT, Khurshid S. Eur J Prev Cardiol. 2026 Feb 25:zwag127. PMID: 41742363.
Patterns and Clinical Outcomes of Physical Activity and Sedentary Behavior Across 20 Million Days of Wearable Monitoring in U.S. Adults. Nargesi AA, D’Souza V, Shnitzer T, Kadaifciu A, Cremer A, Jurgens SJ, Mack N, Lupi R, Azuine R, Ginsburg GS, Lunt C, Anderson CD, Friedman S, Ellinor PT, Maddah M. medRxiv [Preprint]. 2026 Feb 12:2026.02.11.26346079. PMID: 41728275.
Recurrent Gastrointestinal Bleeding in Patients With Atrial Fibrillation Treated With Left Atrial Appendage Occlusion. Ramadan A, Doma M, Felix IF, Kamel I, Ahmed MS, Mahmoud AK, Ismayl M, Karara Y, Villablanca PA, Saw J, DeSimone CV, Goldsweig AM. Pacing Clin Electrophysiol. 2026 Feb 21. PMID: 41721735.
Do World-Wide Policy Initiatives for Regulating Health Care Related Artificial Intelligence Safeguard the Declaration of Helsinki? Armoundas AA, Loscalzo J. EClinicalMedicine. 2026 Feb 11;92:103784. PMID: 41717587. Review.
Polygenic Risk Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials. Abou-Karam R, Kim MS, Jemma Cho SM, Bitar F, Gady S, Cheng F, Thompson AG, Karlson EW, Natarajan P, Ellinor PT, Foldyna B, Ghebremichael MS, Atlas SJ, Ridker PM, Lu MT, Fahed AC. J Am Coll Cardiol. 2026 Feb 6:S0735-1097(25)10563-9. PMID: 41706060.
Rethinking Cholesterol Management in Women: From Short-Term Risk Estimation to Lifecourse Cardiovascular Health. Honigberg MC. J Am Coll Cardiol. 2026 Feb 17;87(6):746-749. PMID: 41705743.
Extracellular Vesicles in Cardiac Amyloidosis: From Pathogenesis to Clinical Applications. Batikyan A, Brown D, Elahmadi Z, Park JH, Ragupathi A, Lohana P, Zoumpourlis P, Shah P, Vishakha M, Mcintosh M, Kladas M, Gokulnath P, Spanos M. Diagnostics (Basel). 2026 Feb 1;16(3):430. PMID: 41681748. Review.
Incidence, Risk Factors, and Outcomes in Stressor-Associated Atrial Fibrillation: Insights From the VITAL-AF Trial. Haimovich JS, Kany S, Chang Y, Borowsky LH, McManus DD, Atlas SJ, Singer DE, Lubitz SA, Ellinor PT, Khurshid S. Circulation. 2026 Feb 10;153(6):367-378. PMID: 41662456.
Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction. Small AM, Yang TY, Itoh S, Thériault S, Dufresne L, Kurosawa R, Komuro I, Matsuda K, Vy HMT, Farber-Eger EH, Shaffer LL, Boulier KM, Corey KM, Ramaker ME, Laporte F, Schott JJ, Le Scouarnec S, Singh SA, Sonawane AR, Smith HA, Rafaels N; Colorado Center for Personalized Medicine; Ghouse J, Raja AA, Ostrowski SR, Sørensen E, Mikkelsen C, Pedersen OB, Erikstrup C, Ullum H; DBDS Genomic Consortium; Sveinbjornsson G, Gudbjartsson DF, Abner E; Estonian Biobank Research Team; Lee J, Ganna A, Nowak-Göttl U, Finer S; Genes Health Research Team; Schumacher J, Maj C, Al-Kassou B, Nickenig G, Trenkwalder T, Dreβen M, Krane M, Nöthen MM, Moksnes MR, Brumpton BM, Knight S, Knowlton KU, Nadauld L, Debiec R, Musameh MD, Braund PS, Nelson CP, Czuba T, Melander O, Selvaraj MS, Koyama S, Bhukar R, Ruan Y, Ljungberg J, Damrauer SM, Levin MG, Franke A, Berger K, Ruff CT, Melloni GEM, Kamanu FK, Ito K, Do R, Loos RJF, Schunkert H, Wells QS, Shah SH, Le Tourneau T, Messika-Zeitoun D, Gignoux C, Bundgaard H, Larsson SC, Michaëlsson K, Holm H, Helgadottir A, Esko T, van Heel DA, Mathieu P, Samani NJ, Smith JG, Söderberg S, Rader DJ, Marston NA, Sabatine MS, Pasaniuc B, Cho K, Wilson PWF, O’Donnell CJ, Stefansson K, Bossé Y, Aikawa E, Engert JC, Peloso GM, Natarajan P, Thanassoulis G. Nat Genet. 2026 Jan;58(1):57-66. PMID: 41419686.
Multitrait Analyses Identify Genetic Variants Associated With Aortic Valve Function and Aortic Stenosis Risk. Kany S, Rämö JT, Hou C, Jurgens SJ, Khurshid S, Nauffal V, Cunningham JW, Lau ES, Koyama S; FinnGen; Ho JE, Olgin JE, Elmariah S, Palotie A, Lindsay ME, Ellinor PT, Pirruccello JP. Nat Genet. 2026 Jan;58(1):47-56. PMID: 41419685.
Depression and Anxiety Associate With Adverse Cardiovascular Events via Neural, Autonomic, and Inflammatory Pathways. Abohashem S, Qamar I, Grewal SS, Civieri G, Islam S, Aldosoky W, Bollepalli S, Rosovsky RP, Seligowski AV, Shin LM, Armoundas AA, Osborne MT, Tawakol A. Circ Cardiovasc Imaging. 2026 Jan;19(1):e017706. PMID: 41404670.
Clonal Hematopoiesis and Major Adverse Cardiac Events in People With HIV: Insights From the REPRIEVE Trial. Xue L, Bhattacharya R, Uddin MM, Nakao T, Zou R, Patel A, Haidermota S, Niroula A, Viscosi V, Postupaka D, Bhatnagar A, Finneran P, Bernardo R, Diggs MR, Fitch KV, Chu SM, McCallum S, Currier JS, Fichtenbaum CJ, Malvestutto CD, Aberg JA, Bloomfield GS, Ribaudo HJ, Zanni MV, Libby P, Hornsby W, Lu MT, Douglas PS, Grinspoon SK, Natarajan P. Arterioscler Thromb Vasc Biol. 2026 Jan;46(1):168-177. PMID: 41195533.
A Deep Learning Model to Identify Mitral Valve Prolapse From the Echocardiogram. Al-Alusi MA, Lau ES, Small AM, Reeder C, Shnitzer T, Andrews CT, Kany S, Rämö JT, Haimovich JS, Khurshid S, Sanborn DY, Picard MH, Ho JE, Maddah M, Ellinor PT. JACC Cardiovasc Imaging. 2026 Jan;19(1):18-29. PMID: 41031982.
Pearls and Pitfalls in the Diagnosis and Management of Mitral Annular Calcification. Dhont S, van den Acker GPH, Churchill TW, Bertrand PB. Heart. 2026 Jan 20:heartjnl-2025-325937. PMID: 41558851.
An iInflammatory and Quiescent HSC Subpopulation Expands With Age in Humans. Safina KR, Salik B, Kotliar D, Curtis M, Good JD, Weng C, David S, Raychaudhuri S, Kreso A, Trowbridge JJ, Sankaran VG, van Galen P. Genome Biol. 2026 Jan 16;27(1):30. PMID: 41546063.
The OurHealth Study: A digital genomic cohort for cardiometabolic risk mechanisms in US South Asians. Ganesh S, Bhattacharya R, Bhatnagar A, Madnani R, Russo C, Haidermota S, Oruganty B, Bhavsar H, Shah P, Pitafi S, Uppal N, Sengupta N, Rice K, Conomos MP, Dave R, Khandelwal A, Patel AP, Paruchuri K, Levitsky Y, Parulkar SS, Khera R, Gulati M, Khera AV, Hornsby WE, Palaniappan L, Natarajan P. NPJ Digit Med. 2026 Jan 16;9(1):151. PMID: 41545632. Review.
A Road Map to Understanding Cardiovascular Disease in Diabetes: From the AHA Strategically Focused Research Network in Cardiometabolic Health and Type 2 Diabetes. Abel ED, Ahima RS, Anderson EJ, Berg DD, Berger JS, Das S, Feinberg MW, Fisher EA, Garshick MS, Giannarelli C, Goldberg IJ, Hamburg NM, Kim SF, Moura FA, Ndumele CE, Newman JD, Sabatine MS, Selvin E, Shah R. Circ Res. 2026 Jan 16;138(2):e325798. PMID: 41538415. Review.
Access to Digital Health Technologies: Personalized Framework and Global Perspectives. Narayan SM, Chung MK, Adedinsewo D, Brant LCC, Davis LL, Duncker D, Hall JL, Han JK, Lam CSP, Lewis E, Loscalzo J, Márquez MF, Rahimzadeh V, Rodriguez F, Sanders P, Svennberg E, Stein K, Turakhia M, Yancy C, Armoundas AA. Nat Rev Cardiol. 2026 Jan;23(1):9-22. PMID: 40670723. Review.
An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans. Safina KR, Kotliar DA, Curtis M, Good JD, Weng C, David S, Raychaudhuri S, Kreso A, Trowbridge J, Sankaran VG, van Galen P. Genome Biol. 2026 Jan 16;27(1):30. PMID:40949975.
Leveraging the Shared and Opposing Genetic Mechanisms in the Heritable Cardiomyopathies. Kramarenko DR, Haydarlou P, Powell GJ, Rämö JT, Janan R, Prince C, Zimmerman DS, Theotokis P, Thami PK, Haas J, Garnier S, Rühle F, Poel E, Schmidt AF, Day S, Helms A, Lampert R, Parikh V, Ingles J, Olivotto I, Lakdawala N, Owens A, Saberi S, Stendhal J, Ashley E, Gray B, Russell MW, Ryan TD, Rossano JW, Abrams D, Miller E, Lin K, Maurizi N, Argiro A, Berry C, Cooper R, Flett AS, Gardner RS, Greenwood JP, Halliday BP, Hutchings D, Mahmod M, McCann GP, Page SP, Peebles C, Raman B, Swoboda P, Varnava A, Wright D, Prasad S, Cook S, Tayal UP, Buchan R, Walsh R, Wilde AAM, Meder B, Charron P, Goel A, Amin AS, Ellinor PT, Aragam KG, Tadros R, Pinto YM, Ho CY, Watkins H, Ware JS, Bezzina CR, Jurgens SJ. Res Sq [Preprint]. 2026 Jan 27:rs.3.rs-8346032. PMID: 41646289.
Addressing Patient Concerns About the ‘Newness’ and Long-Term Safety of GLP-1 Receptor Agonists: A Clinician’s Guide to Counseling. Shah PP, Bhattacharya R. Am J Prev Cardiol. 2026 Jan 16;26:101418. PMID: 41608676.
Comprehensive Benchmarking Single and Multi Ancestry Polygenic Score Methods With the PGS-Hub Platform. Chen X, Wang F, Zhao H, Hao J, A Y, Yang X, Xu T, Zhou Y, Chen Q, Zhang R, Yu K, Zaib K, Fahed AC, Zhai G, Wang M. Nat Commun. 2026 Jan 25;17(1):2014. PMID: 41580418.
Genetic Predisposition to Elevated Lipoprotein(A) in Early-Onset Myocardial Infarction. Ardissino A, Roberts A, Maglietta G, Niccoli G, Ardissino M, Jemma Cho SM, Honigberg MC, Asselta R, de Marvao A, Ardissino D. Eur J Prev Cardiol. 2026 Jan 24:zwag056. PMID: 41578955.
Clonal Hematopoiesis and Major Adverse Cardiac Events in People With HIV: Insights From the REPRIEVE Trial. Xue L, Bhattacharya R, Uddin MM, Nakao T, Zou R, Patel A, Haidermota S, Niroula A, Viscosi V, Postupaka D, Bhatnagar A, Finneran P, Bernardo R, Diggs MR, Fitch KV, Chu SM, McCallum S, Currier JS, Fichtenbaum CJ, Malvestutto CD, Aberg JA, Bloomfield GS, Ribaudo HJ, Zanni MV, Libby P, Hornsby W, Lu MT, Douglas PS, Grinspoon SK, Natarajan P. Arterioscler Thromb Vasc Biol. 2026 Jan;46(1):168-177. PMID: 41195533.
The Continuum of Prevention and Heart Failure in Cardiovascular Medicine: A Joint Scientific Statement from the Heart Failure Society of America and The American Society for Preventive Cardiology. Lala A, Beavers C, Blumer V, Brewer L, DE Oliveira-Gomes D, Dunbar SB, Every H, Ferraro R, Ky B, Januzzi JL, Marvel F, Mentz RJ, Michos E, Narula J, Nasir K, Natarajan P, Peterson LA, Rodriguez F, Shapiro MD, Skowronski J, Starling RC, Taub P, Tedford RJ, Youmans Q, Zieroth S, Gulati M. J Card Fail. 2026 Jan;32(1):75-105. PMID: 40816577. Review.
Depression and Anxiety Associate With Adverse Cardiovascular Events via Neural, Autonomic, and Inflammatory Pathways. Abohashem S, Qamar I, Grewal SS, Civieri G, Islam S, Aldosoky W, Bollepalli S, Rosovsky RP, Seligowski AV, Shin LM, Armoundas AA, Osborne MT, Tawakol A. Circ Cardiovasc Imaging. 2026 Jan;19(1):e017706. PMID: 41404670.
CHIP, LOY, and Other Clonal Hematopoiesis Subtypes in Cardiovascular Disease. Honigberg MC. J Am Coll Cardiol. 2026 Jan 6;87(1):49-51. PMID: 41498478.
Reply: Powering Evidence and Bridging Gaps on South Asian and African Enrollment in Cardiovascular RCTs. Uppal N, Patel AP, Bhatt DL, Natarajan P. JACC Asia. 2026 Jan;6(1):103-104. PMID: 41498466.
SStructural and Functional Gastrointestinal Abnormalities in ACTA2 R179H Mice Modeling Multisystemic Smooth Muscle Dysfunction Syndrome. Rahman AA, Stavely R, Ott LC, Han CY, Ohishi K, Hotta R, Burns AJ, Das S, Da Cruz E, Tambala D, Lindsay ME, Musolino PL, Goldstein AM. JCI Insight. 2026 Jan 6;11(4):e190469. PMID: 41493807.

2025

Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation. Zhang R, Kim MS, Yin W, Liao S, Zhu X, Yang X, Yu K, Sui Y, Roselli C, Khurshid S, Chen Q, A Y, Zhao H, Xu T, Huang X, Pu J, Liu Z, Natarajan P, Zhai G, Ellinor PT, Wang M, Fahed AC. JAMA Cardiol. 2025 Dec 1;10(12):1240-1248. PMID: 41060636.
Non-genetic factors determine deep learning identified ECG differences between black and white healthy subjects. Bollepalli SC, Isselbacher EM, Singh JP, Armoundas AA. NPJ Cardiovasc Health. 2025;2(1):51. PMID: 41080706.
AstroGreen transgenic mouse illuminates the trafficking of astrocyte-derived extracellular vesicles. Nieland L, Haidar EA, Rufino-Ramos D, Prabhakar S, Samaha Y, Breyne K, Fordjour FK, Das S, Broekman MLD, Gould S, Breakefield XO, Abels ER. Mol Cell Neurosci. 2025 Dec;135:104051. PMID: 41072785.
Trends in Prevalence, Treatment, and Control of Cardiometabolic Risk Factors Among Adults With Hypertension in the United States, 1999-2023. Lee HH, Crawford EB, Cho SMJ, Krawisz AK, Juraschek SP, Cluett JL, Lee H, Kim HC, Natarajan P, Wadhera RK, Secemsky EA. J Am Coll Cardiol. 2025 Dec 23;86(25):2577-2593. PMID: 41295934.
Open wide: A fresh look at periodontitis and atrial fibrillation. Haimovich JS, Paras ML, Khurshid S. Eur J Prev Cardiol. 2025 Dec 9:zwaf762. PMID: 41362944.
The role of bioactive lipids and eicosanoid metabolites in acute exercise in adults: Insights into human cardiorespiratory fitness. Ambatipudi M, Roshandelpoor A, Guseh JS, Kosyakovsky LB, Alotaibi M, Cheng S, Jain M, Lewis GD, Ho JE. Physiol Rep. 2025 Dec;13(23):e70671. PMID: 41351269.
Self-quenched tRNA reporters for imaging tRNA-derived RNA biogenesis. Li G, Das S. Methods Enzymol. 2025;711:324-335. PMID: 39952713.
Geroscience in heart failure: the search for therapeutic targets in the shared pathobiology of human aging and heart failure. Castro C, Delwarde C, Shi Y, Roh J. J Cardiovasc Aging. 2025;5(1):10.20517/jca.2024.15. PMID: 40297496.
Machine learning based, subject-specific, gender and race independent, non-invasive estimation of the arterial blood pressure. Sevakula RK, Bota PJ, Kassab MB, Bollepalli SC, Thambiraj G, Boyer R, Isselbacher EM, Armoundas AA. NPJ Cardiovasc Health. 2025;2(1):41. PMID: 40757190.
Drivers of Atherosclerotic Cardiovascular Disease in South Asians: Current Insights and Future Directions. Patel A, Nicholls SJ, Chew DP, Lin AK, Natarajan P, Nelson AJ, Nerlekar N. JACC Asia. 2025 Dec 1:S2772-3747(25)00646-5. PMID: 41712894. Review.
Prediction and Longer-Term Outcomes of All-cause and Cardiovascular Mortality in the HEART-FID Trial. Ezekowitz JA, Mulder H, Mentz RJ, Butler J, DE Pasquale CG, Lewis GD, O’Meara E, Ponikowski P, Troughton RW, Wong YW, Adamczyk R, Numan S, Blackman N, Rockhold FW, Hernandez AF. J Card Fail. 2025 Dec;31(12):1822-1833.PMID: 39890013.
Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. Maamari DJ, Biddinger KJ, Jurgens SJ, Rämö JT, Gaziano L, Zheng A, Challa SP, Hayes D, Gongora CA, Choi SH, Chang KM, Tsao PS, Arany Z, Thavendiranathan P, Huffman JE, Fahed AC, Sarma AA, Neilan TG, Khera AV, Ellinor PT, Aragam KG. JAMA Cardiol. 2025 Nov 1;10(11):1138-1146. PMID: 41032333.
Clonal Hematopoiesis and Risk of New-Onset Myocarditis and Pericarditis. Schuermans A, Flynn S, Niroula A, Uddin MM, Sinnaeve P, Budts W, Conrad N, Ebert BL, Libby P, Lin AE, Weber BN, Natarajan P, Honigberg MC. JAMA Cardiol. 2025 Nov 1;10(11):1147-1156. PMID: 40884495.
Combining Polygenic Risk With LDL, CRP, and Lp(a) to Predict Coronary Artery Disease: UK Biobank Study. Khetarpal SA, Shi Z, Goyal A, Patel AP, Urbut SM, Ballantyne CM, Natarajan P, Khera AV, Xu J, Qamar A. J Am Coll Cardiol. 2025 Nov 25;86(21):2077-2080. PMID: 41123520.
Ex Vivo Phosphorus-31 Solid State Magnetic Resonance Spectroscopy Identifies Compositional Differences Between Bone Mineral and Calcified Vascular Tissues. Yao J, Farrar CT, Aikawa E, Sosnovik DE, Moon BF, Kulkarni A, Ackerman JL. medRxiv [Preprint]. 2025 Nov 26:12:1689116. PMID: 41383646.
Endothelial adenosine receptor 2A loss alleviates diabetic vascular calcification by blocking CREB1-SNAI1-driven EndMT. Zhou Y, Zhao D, Ma Q, Xu J, Cai Y, Yang Q, Da Q, Sheridan K, Zhang C, Miller CL, Malhotra R, Xu S, Hong M, Huo Y. Pharmacol Res. 2025 Nov;221:107981. PMID: 41067595.
Implications of integrating large language models into clinical decision making. Christof M, Armoundas AA. Commun Med (Lond). 2025 Nov 20;5(1):490. PMID: 41266752. Review.
Cellular and molecular imaging of coronary atherosclerosis: clinical applications. Jaffer FA, Dweck MR, Tearney GJ, Libby P, Tawakol A. Eur Heart J. 2025 Nov 12:ehaf804. PMID: 41222955.
Targeting adenosine 2A receptor signaling suppresses vascular calcification by restraining smooth muscle osteogenic differentiation. Zhou Y, Zhao D, Ma Q, Lee S, Roh K, Cai Y, Xu J, Yang Q, Da Q, Liu Z, Ouyang K, Chantemele EJB, Hong M, Miller CL, Malhotra R, Zhang C, Xu S, Huo Y. Pharmacol Res. 2025 Nov;221:108012. PMID: 41201506.
Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population. Enzan N, Miyazawa K, Koyama S, Kurosawa R, Ieki H, Yoshida H, Takechi F, Fukuyama M, Osako R, Tomizuka K, Liu X, Ozaki K, Onouchi Y; BioBank Japan Project; Matsuda K, Momozawa Y, Aburatani H, Kamatani Y, Yamaguchi T, Akazawa H, Node K, Ellinor PT, Levin MG, Damrauer SM, Voight BF, Joseph J, Sun YV, Terao C, Ninomiya T, Komuro I, Ito K. Nat Commun. 2025 Nov 3;16(1):9680. PMID: 41184235.
Human plasma proteomic profile of clonal hematopoiesis. Yu Z, Vromman A, Nguyen NQH, Schuermans A, Li L, Rentz T, Nakao T, Vellarikkal SK, Uddin MM, Niroula A, Griffin G, Honigberg MC, Lin AE, Gibson CJ, Katz DH, Tahir UA, Fang S, Dron JS, Pan M, Haidermota S, Ganesh S, Antoine T, Weinstock J, Austin TR, Vasan RS, Peloso GM, Hornsby W, Ganz P, Manson JE, Haring B, Kooperberg C, Reiner AP, Bis JC, Psaty BM, Min YI, Correa A, Lange LA, Post WS, Rotter JI, Rich SS, Wilson JG, Ebert BL, Yu B, Ballantyne CM, Coresh J, Sankaran VG, Bick AG, Jaiswal S, Gerszten RE; NHLBI Trans-Omics for Precision Medicine; Libby P, Gupta RM, Natarajan P. Nat Commun. 2025 Nov 27;16(1):11688. PMID: 41309676.
Artificial intelligence-enabled analysis of handheld single-lead electrocardiograms to predict incident atrial fibrillation: an analysis of the VITAL-AF randomized trial. Khurshid S, Friedman SF, Al-Alusi MA, Kany S, Sommers T, Anderson CD, Ho JE, McManus DD, Borowsky LH, Ashburner JM, Lubitz SA, Atlas SJ, Maddah M, Singer DE, Ellinor PT. NPJ Digit Med. 2025 Nov 26;8(1):776. PMID: 41299008.
Genetics and context for precision health in Greater Boston. Koyama S, Wang Y, Paruchuri K, Uddin MM, Cho SMJ, Urbut SM, Sui Y, Fahed AC, Kamineni H, Haidermota S, Hornsby WE, Green RC, Daly MJ, Neale BM, Ellinor PT, Smoller JW, Slaugenhaupt SA, Lebo MS, Karlson EW, Martin AR, Natarajan P. Nat Commun. 2025 Nov 26;16(1):11661. PMID: 41298473.
Neutrophils in Myocardial Infarction. Nahrendorf M, Kumowski N, Steffens S. JACC Basic Transl Sci. 2025 Nov;10(11):101408. PMID: 41298044.
Ex vivo phosphorus-31 solid state magnetic resonance spectroscopy identifies compositional differences between bone mineral and calcified vascular tissues. Yao J, Farrar CT, Aikawa E, Sosnovik DE, Moon BF, Kulkarni A, Ackerman JL. Front Cardiovasc Med. 2025 Nov 26;12:1689116. PMID: 41383646.
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target. Schuermans A, Honigberg MC. Nat Rev Cardiol. 2025 Nov;22(11):845-856. PMID: 40175709. Review.
The electrocardiogram reimagined: AI-ECG as a prognostic beacon for valvular heart disease. Armoundas AA. Eur Heart J. 2025 Nov 21;46(44):4838-4841. PMID: 40910373.
Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial. Mohammadnia N, Xue L, Vestjens LTW, Uddin MM, Niroula A, de Kleijn DPV, Mosterd A, Fiolet ATL, Nakao T, Eikelboom JW, Cetinyurek-Yavuz A, Peloso GM, Bax WA, Riksen NP, Natarajan P, Cornel JH, El Messaoudi S, Honigberg MC. J Am Coll Cardiol. 2025 Nov 25;86(21):1983-1996. PMID: 40892620.
South Asian Representation in Cardiovascular Disease Randomized Controlled Trials: A Systematic. Review. Uppal N, Patel AP, Bhatt DL, Natarajan P. JACC Asia. 2025 Oct;5(10):1244-1256. PMID: 40817904.
Association of Health-Related Social Needs With Adverse Pregnancy Outcomes Among Black and Latina Individuals. Belak L, James K, Rana M, Viscosi V, Eweka I, Busso J, Sarma A, Powe C, Economy K, Honigberg MC. Obstet Gynecol. 2025 Oct 1;146(4):541-543. PMID: 40609094.
Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women. Ezzat D, Uddin MM, Xue L, Pershad Y, Zhang S, Collins JM, Kitzman JO, Jaiswal S, Desai P, Kooperberg C, Bick AG, Natarajan P, Manson JE, Whitsel EA, Reiner AP, Honigberg MC. J Am Coll Cardiol. 2025 Oct 14;86(15):1093-1106. PMID: 40864016.
Clonal hematopoiesis of indeterminate potential and the risk of cognitive impairment in the Women’s Health Initiative Memory Study. Jakubek YA, Smith AP, Leng XI, Hall ME, Ezzat D, Pershad Y, Collins JM, Uddin MM, Fardo DW, Natarajan P, Bick AG, Kitzman JO, Honigberg MC, Hayden KM, Manson JE, Jaiswal S, Whitsel EA, Reiner AP. Alzheimers Dement. 2025 Oct;21(10):e70737. PMID: 41025350.
Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α. Khetarpal SA, Li H, Vitale T, Rhee J, Challa S, Castro C, Pabel S, Sun Y, Liu J, Bogoslavski D, Vargas-Castillo A, Smythers AL, Blackmore KA, Grauvogel L, Mittenbühler MJ, Khandekar MJ, Curtin C, Narvaez-Paliza JM, Wang C, Houstis NE, Sprenger HG, Jurgens SJ, Biddinger KJ, Kuznetsov A, Freeman R, Ellinor PT, Nahrendorf M, Paulo JA, Gygi SP, Dumesic PA, Asnani A, Aragam KG, Puigserver P, Roh JD, Spiegelman BM, Rosenzweig A. Nat Cardiovasc Res. 2025 Oct;4(10):1277-1294. PMID: 40993371.
Response to letter JHH-25-0238 in relation to our article on Journal of Human Hypertension. Angelaki E, Marketou ME, Fragkiadakis K, Maragkoudakis S, Tsironis GP. J Hum Hypertens. 2025 Oct;39(10):737-738. PMID: 40973780.
Contemporary Burden of Cardiovascular Disease in Pregnancy: Insights From a Real-World Pregnancy Electronic Health Record Cohort. Lau ES, D’Souza V, Zhao Y, Reeder C, Goldberg R, Flores M, Economy KE, Maddah M, Khurshid S, Ellinor PT, Ho JE. Circulation. 2025 Oct 14;152(15):1044-1055. PMID: 41048030.
Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration. Lekkos K, Hu Z, Nguyen PD, Honkoop H, Sengul E, Alonaizan R, Koth J, Ying J, Lemieux ME, Kenward A, Keeley S, Spanjaard B, Kennedy BWC, Sun X, Banecki K, Potts HG, Ruggiero G, Montgomery J, Panáková D, Junker JP, Heather LC, Wang X, Gonzalez-Rosa JM, Bakkers J, Mommersteeg MTM. Nat Cardiovasc Res. 2025 Oct;4(10):1363-1380. PMID: 41034455.
A systems approach to target discovery identifies the role of lncRNA-SPANXA2-OT1 in macrophage chemotaxis. Jha PK, Chelvanambi S, Nakamura Y, Itto LY, Vijay A, Lupieri A, Barbeiro MC, Le TD, Nascimento CB, Kasai T, Whelan M, Hosokawa D, Becker-Greene D, Singh SA, Aikawa E, Uchida S, Aikawa M. JCI Insight. 2025 Oct 9;10(21):e191274. PMID: 41066194.
B cells promote atrial fibrillation via autoantibodies. Yamazoe M, Ting KKY, Lee IH, Bapat A, Lewis A, Xiao L, Pulous FE, Mentkowski K, Paccalet A, Momin N, Seung H, Dolejsi T, Kumowski N, Schloss MJ, Iwamoto Y, Ramos G, Chan K, Antoniades C, Casadei B, Swirski FK, Ellinor PT, Naxerova K, Pabel S, Hulsmans M, Nahrendorf M. Nat Cardiovasc Res. 2025 Oct;4(10):1381-1396. PMID: 41062615.
Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations. Weinstock JS, Chaudhry SA, Ioannou M, Viskadourou M, Reventun P, Jakubek YA, Liggett LA, Laurie C, Broome JG, Khan A, Taylor KD, Guo X, Peyser PA, Boerwinkle E, Chami N, Kenny EE, Loos RJ, Psaty BM, Tracy RP, Brody JA, Yun JH, Cho MH, Vasan RS, Kardia SL, Smith JA, Raffield LM, Bidulescu A, O’Brien EC, de Andrade M, Rotter JI, Rich SS, Tracy RP, Chen YI, Gu CC, Hsiung CA, Kooperberg C, Haring B, Nassir R, Mathias R, Reiner A, Sankaran VG, Lowenstein CJ, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Natarajan P, Jaiswal S, Bick A, Post WS, Scheet P, Auer P, Karantanos T, Battle A, Arvanitis M. Nat Commun. 2025 Oct 16;16(1):9194. PMID: 41102182.
Open for Business Next Year?: μFR Predicts Graft Patency After Coronary Artery Bypass Grafting. Goldsweig AM, Doma M. JACC Cardiovasc Interv. 2025 Oct 13;18(19):2335-2337.PMID: 41093450.
Metabolic Memory Resides in the Hematopoietic Marrow and in Arterial Resident Leukocytes. Ferreira AV, Nahrendorf M. JACC Basic Transl Sci. 2025 Oct;10(10):101392. PMID: 41161897.
Use of artificial intelligence in predicting in-hospital cardiac and respiratory arrest in an acute care environment-implications for clinical practice. Thambiraj G, Bazoukis G, Ghabousian A, Zhou J, Bollepalli SC, Isselbacher EM, Donahue V, Singh JP, Armoundas AA. Front Med Technol. 2025 Oct 10;7:1681059. PMID: 41142406.
State-dependent release of extracellular particles with distinct α2,6-sialylation patterns and small RNA cargo related to neuroinflammation. Garcia-Contreras M, Lima C, Alsop E, Kaszala B, Meechoovet B, Purnell B, Jiang N, Saftics A, Tang C, Walsh OD, Holland S, Fay J, Smith B, Sigdel KP, Van Keuren-Jensen K, Jovanovic-Talisman T, Das S. bioRxiv [Preprint]. 2025 Oct 31:2025.10.30.684535. PMID: 41279558.
Exploring Size Exclusion Chromatography Columns 20 and 35 nm Pore Size Effect for Isolation of Extracellular Vesicles. Kaszala B, Scarsella V, Bomb K, Fay J, Smith B, Gokulnath P, Desai R, Kulkarni RN, Das S, Garcia-Contreras M. bioRxiv [Preprint]. 2025 Oct 20:2025.10.20.682612. PMID: 41279246.
MicroRNAs in the biology and hallmarks of neurodegenerative diseases. Dhuppar S, Poller WC, Murugaiyan G. Trends Mol Med. 2025 Oct;31(10):955-969. PMID: 40199696. Review.
ALADYNOULLI: A Bayesian approach to disease progression modeling for genomic discovery and clinical prediction. Urbut SM, Ding Y, Nakao T, Jiang X, Gaffney L, Misra A, Hornsby W, Smoller JW, Gusev A, Natarajan P, Parmigiani G. medRxiv [Preprint]. 2025 Oct 13:2024.09.29.24314557. PMID: 39568791.
IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk. Zhang L, Omarov M, Xu L, deGoma E, Natarajan P, Georgakis MK. Nat Cardiovasc Res. 2025 Sep;4(9):1172-1186. PMID: 40858837.
The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity. Chatterjee E, Betti MJ, Sheng Q, Lin P, Emont MP, Li G, Amancherla K, Garcia-Contreras M, Gokulnath P, Limpitikul WB, Whittaker OR, Luong K, Azzam C, Gee D, Hutter M, Flanders K, Sahu P, Flynn CR, Brown J, Yu D, Rosen ED, Van-Keuren Jensen K, Gamazon ER, Shah R, Das S. Cell Genom. 2025 Sep 10;5(9):100925. PMID: 40669467.
Electrocardiogram-Based Artificial Intelligence to Identify Coronary Artery Disease. Kany S, Friedman SF, Al-Alusi M, Khurshid S, Rämö JT, Pipilas D, Pirruccello JP, Reeder C, Philippakis AA, Ho JE, Maddah M, Ellinor PT, Fahed AC. JACC Adv. 2025 Sep;4(9):102041. PMID: 40749517.
The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism. Krawczyk J, O’Connor W, Vendramini P, Schell M, Biddinger KJ, Kanke M, Pengo G, Semova I, Fougeray T, Haigis M, Aragam KG, Lamers WH, Tsai LT, Sethupathy P, Biddinger SB. Mol Metab. 2025 Sep;99:102208. PMID: 40675550.
On Macrophage Culture. Kumowski N, Nahrendorf M. JACC Basic Transl Sci. 2025 Sep;10(9):101375. PMID: 40992828.
Outcomes and Management of Stressor-Associated Atrial Fibrillation: JACC State-of-the-Art. Review. Haimovich JS, Kany S, Ajufo E, Andrade JG, Benjamin EJ, Healey JS, Kirchhof P, Lubitz SA, McIntyre WF, Rienstra M, Sanders P, Schnabel RB, Ellinor PT, Khurshid S. J Am Coll Cardiol. 2025 Sep 23;86(12):910-939. PMID: 40962378. Review.
Automated Deep Learning-Based Detection of Early Atherosclerotic Plaques in Carotid Ultrasound Imaging. Omarov M, Zhang L, Jorshery SD, Malik R, Das B, Bellomo TR, Mansmann U, Menten MJ, Natarajan P, Dichgans M, Kalic M, Raghu VK, Berger K, Anderson CD, Georgakis MK. medRxiv [Preprint]. 2025 Sep 3:2024.10.17.24315675. PMID: 39484270.
A Polygenic Risk Score to Predict Incident Heart Failure Across the Spectrum of Cardiovascular Risk. Haller PM, Melloni GEM, Berg DD, Kamanu FK, Lai YP, Antman EM, Bhatt DL, Bonaca MP, Cannon CP, Giugliano RP, O’Donoghue ML, Scirica BM, Wiviott SD, Chasman D, Everett BM, Braunwald E, Morrow DA, Ridker PM, Ellinor PT, Sabatine MS, Ruff CT, Marston NA. J Am Coll Cardiol. 2025 Sep 23;86(12):860-873. PMID: 40864011.
Extracellular RNAs in Liquid Biopsy: Applications in MASLD and MASH Diagnosis and Monitoring. Raptis D, Kolli ST, Agarwal S, Komminni PK, Bhattarai P, Hablani P, Kumar R, Das P, McIntosh M, Kladas M, Gokulnath P, Spanos M. Diagnostics (Basel). 2025 Sep 16;15(18):2346. PMID: 41008718. Review.
Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia. Kumowski N, Pabel S, Grune J, Momin N, Ninh VK, Stengel L, Mentkowski KI, Iwamoto Y, Zheng Y, Lee IH, Matthias J, Wirth JO, Pulous FE, Seung H, Paccalet A, Muse CG, Ting KKY, Delgado P, Lewis AJM, Kaushal V, Kreso A, Brown D, Hayat S, Kramann R, Swirski FK, Naxerova K, Propheter DC, Hooper LV, Moskowitz MA, King KR, Rosenthal N, Hulsmans M, Nahrendorf M. Science. 2025 Sep 4;389(6764):1043-1048. PMID: 40906843.
Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation: Results in 18,000 Clinical Trial Participants. Jurgens SJ, Melloni GEM, Kany S, Fabritz L, Rämö JT, Goette A, Kamanu FK, Berg DD, Magnussen C, Choi SH, Bonaca MP, Giugliano RP, Scirica BM, Wiviott SD, Bhatt DL, Steg PG, Raz I, Braunwald E, Pirruccello JP, Sabatine MS, Marston NA, Kirchhof P, Ellinor PT, Ruff CT. J Am Coll Cardiol. 2025 Sep 9;86(10):738-753. PMID: 40903137.
Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals. Selvaraj MS, Li X, Li Z, Van Buren E, Haidermota S, Postupaka D, et al. Genome Biol. 2025 Sep 9;26(1):273. PMID: 40926209.
Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis. Haj AK, Paul DS, Jurgens SJ, Eswaran H, Weng LC, Ryu J, Rodriguez Espada A, Chaudhry S, Feingold LM, Burke K, Koyama S, Wang X, Francis J, Choi SH, Mackman N, Bergmeier W, Burgin A, Rämö JT, Ellinor PT, Grover SP, Bendapudi PK. Nat Commun. 2025 Sep 1;16(1):8176. PMID: 40890099.
Risk stratification of chest pain in the emergency department using artificial intelligence applied to electrocardiograms. Haimovich JS, Kolossváry M, Alam R, Padrós-Valls R, Lu MT, Aguirre AD. Open Heart. 2025 Sep 1;12(2):e003343. PMID: 40889954.
Immune system influence on physiology. Nahrendorf M, Ginhoux F, Swirski FK. Science. 2025 Aug 7;389(6760):594-599. PMID: 40773571. Review.
A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy. Li G, Sun L, Xin C, Hao T, Kharel P, Manning AC, O’Connor CL, Moore H, Lei S, Gokulnath P, Yang X, Sharma R, Garcia-Mansfield K, Pantham P, Xiao C, Wang HY, Chatterjee E, Yim S, Ren LB, Spanos M, Zhu H, Li H, Lei J, Markmann JF, Laurent LC, Rossi JJ, Akeju O, Sheng Q, Shah RV, Goddard WA 3rd, Lowe TM, Pirrotte P, Bitzer M, Ivanov P, Bonventre JV, Das S. Science. 2025 Aug 28;389(6763):eadp5384. PMID: 40674449.
When Close Is Not Close Enough: Cardiomyopathy After Deep Septal Pacing. Shaik A, Frankel DS, Khurshid S. J Cardiovasc Electrophysiol. 2025 Aug;36(8):1996-1998. PMID: 40631723.
Importance of Clinical, Laboratory, and Genetic Risk Factors for Incident CAD. Bhattacharya R, Marnell CS, Cho SMJ, Patel AP, Ruan Y, Koyama S, Jowell AR, Trinder M, Haidermota S, Lannery K, Honigberg MC, Zekevat SM, Surakka I, Peloso GM, Natarajan P. Circ Genom Precis Med. 2025 Aug;18(4):e004937. PMID: 40605734.
Development of conditional-siRNA programmable riboswitch for targeting adverse cardiac remodeling. Gokulnath P, Salvador AM, Graham C, Han SP, Li G, Kannappan R, Azzam C, Spanos M, Scherer L, Sethu P, Rossi J, Goddard WA 3rd, Das S. Mol Ther Nucleic Acids. 2025 Aug 5;36(3):102667. PMID: 40861898.
AAV hamartin gene therapy in a stochastic, cerebral mouse model of tuberous sclerosis type 1. Abou Haidar E, Prabhakar S, Geffrey AL, Mahamdeh M, Tomeh T, Breyne K, Roumieh E, Gurevich M, Soberman RJ, Wojtkiewicz GR, Chen JW, Han JS, Stemmer-Rachamimov A, Breakefield XO. Mol Ther Methods Clin Dev. 2025 Aug 13;33(3):101556. PMID: 40932991.
The continuum of prevention and heart failure in cardiovascular medicine: A joint scientific statement from the Heart Failure Society of America and the American Society for Preventive Cardiology. Lala A, Beavers C, Blumer V, Brewer L, De Oliveira-Gomes D, Dunbar S, Every H, Ferraro R, Ky B, Januzzi J, Marvel F, Mentz R, Michos E, Narula J, Nasir K, Natarajan P, Peterson LA, Rodriguez F, Shapiro MD, Skowronski J, Starling RC, Taub P, Tedford RJ, Youmans Q, Zieroth S, Gulati M. Am J Prev Cardiol. 2025 Aug 13;24:101069. PMID: 41141606. Review.
Machine Learning-Based Plasma Protein Risk Score Improves Atrial Fibrillation Prediction Over Clinical and Genomic Models. Kim MS, Khurshid S, Kany S, Weng LC, Urbut S, Roselli C, Wijdeveld LFJM, Jurgens SJ, Rämö JT, Ellinor PT, Fahed AC. Circ Genom Precis Med. 2025 Aug;18(4):e004943. PMID: 40525300.
Female-Specific Cardiovascular Risk Factors in Severe Hypercholesterolemia. Jowell AR, Urbut SM, Jemma Cho SM, Liu Y, Schuermans A, Koyama S, Yu Z, Natarajan P, Honigberg MC. JACC Adv. 2025 Aug;4(8):102035. PMID: 40737794.
Machine Learning Identification of Athlete Sport Type Through ECG Analysis. Cofer LB, Churchill TW, Bhuptani R, Inampudi A, Rajvanshi M, Atlason B, Shim SSY, Khurshid S, Chung EH, Baggish A, Guseh JS, Lee K; Cardiovascular Performance Program Study Group. Circ Arrhythm Electrophysiol. 2025 Aug;18(8):e013677. PMID: 40709465.
Profiling the metabolome of older adults who live with overweight/obesity and undiagnosed cognitive impairment. Alvarez KLF, Ortiz-Manrique MM, Davila-Del-Carpio G, Peralta-Mestas A, Lino Cardenas CL. Neuroscience. 2025 Aug 30;582:94-103. PMID: 40701320.
Impact of left-heart myopathy on mitral valve stenosis assessment and interventional outcomes: an in-silico trial. van den Acker GPH, Dhont S, van Loon T, Churchill TW, Timmermans F, Delhaas T, Bertrand PB, Lumens J. Eur Heart J Digit Health. 2025 Aug 19;7(1):ztaf097. PMID: 41574031.
Correlates and consequences of clonal hematopoiesis expansion rate: a 16-year longitudinal study of 6976 women. Pershad Y, Uddin MM, Xue L, Haessler J, Collins JM, Mack TM, Glick E, Glaser V, Zhao K, Jaiswal S, Manson JE, Pandey U, Desai P, Natarajan P, Honigberg MC, Kooperberg C, Whitsel EA, Kitzman JO, Bick AG, Reiner AP. Blood. 2025 Aug 28;146(9):1078-1087. PMID: 40499013.
Cardiac ageing: from hallmarks to therapeutic opportunities. Hastings MH, Zhou Q, Wu C, Shabani P, Huang S, Yu X, Singh AP, Guseh JS, Li H, Lerchenmüller C, Rosenzweig A. Cardiovasc Res. 2025 Aug 28;121(10):1474-1488. PMID: 38918884.
Polygenic Prediction of Peripheral Artery Disease and Major Adverse Limb Events. Flores AM, Ruan Y, Misra A, Cho SMJ, Selvaraj MS, Bellomo TR, Nakao T, Rosenfield K, Eagleton M, Hornsby W, Patel AP, Natarajan P. JAMA Cardiol. 2025 Aug 1;10(8):770-778. PMID: 40397457.
Data Sharing in the PRIMED Consortium: Design, implementation, and recommendations for future policymaking. Smith JL, Wong Q, Hornsby W, Conomos MP, Heavner BD, Kullo IJ, Psaty BM, Rich SS, Tayo B, Natarajan P, Nelson SC; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Data Sharing Working Group, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium. ArXiv [Preprint]. 2025 Feb 12:arXiv:2502.09351v1. PMID: 39990790.
DiscoDivas: Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations. Ruan Y, Bhukar R, Patel A, Koyama S, Hull L, Truong B, Cho SM, Hornsby W, Zhang H, Chatterjee N, Natarajan P. medRxiv [Preprint]. 2025 Aug 5:2024.11.09.24316996. PMID: 39867390.
AHA PREVENT Equations and Cardiovascular Disease Risk in Diverse Health Care Populations. Cho SMJ, Levin M, Chen R, Samarakoon R, Judy R, Hartmann K, Postupaka D, Viscosi V, Farber-Eger E, Fahed AC, Honigberg MC, Patel CJ, Hornsby W, Wells QS, Damrauer SM, Do R, Natarajan P. J Am Coll Cardiol. 2025 Jul 22;86(3):181-192. PMID: 40669956.
Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing. da Rocha JF, Lance ML, Luo R, Schlachter P, Moreira L, Iqbal MA, Kuhn P, Gardner RS, Valaris S, Islam MR, Gassner GM, Mazuera S, Healy K, Shastri S, Hibbert NB, Moran-Figueroa KV, Haley EB, Pfeiffer RD, Aygar S, Kastanenka KV, Brase L, Harari O, Benitez BA, Tucker NR, Wrann CD. Nat Neurosci. 2025 Jul;28(7):1546-1561. PMID: 40506544.
The Somatic Mosaicism across Human Tissues Network. Coorens THH, Oh JW, Choi YA, Lim NS, Zhao B, Voshall A, Abyzov A, Antonacci-Fulton L, Aparicio S, Ardlie KG, Bell TJ, Bennett JT, Bernstein BE, Blanchard TG, Boyle AP, Buenrostro JD, Burns KH, Chen F, Chen R, Choudhury S, Doddapaneni HV, Eichler EE, Evrony GD, Faith MA, Fazzio TG, Fulton RS, Garber M, Gehlenborg N, Germer S, Getz G, Gibbs RA, Hernandez RG, Jin F, Korbel JO, Landau DA, Lawson HA, Lennon NJ, Li H, Li Y, Loh PR, Marth G, McConnell MJ, Mills RE, Montgomery SB, Natarajan P, Park PJ, Satija R, Sedlazeck FJ, Shao DD, Shen H, Stergachis AB, Underhill HR, Urban AE, VonDran MW, Walsh CA, Wang T, Wu TP, Zong C, Lee EA, Vaccarino FM; Somatic Mosaicism across Human Tissues Network. Nature. 2025 Jul;643(8070):47-59. PMID: 40604182. Review.
Molecular Mediators of the Cardiac Benefits of Exercise. Khetarpal SA, Li H, Lerchenmüller C, Rhee J, Rosenzweig A. Circ Res. 2025 Jul 7;137(2):163-183. PMID: 40608861. Review.
Athlete’s Heart Revisited: Historical, Clinical, and Molecular Perspectives. Hsieh PN, Shen S, Chukwurah MI, Churchill TW, Stewart KM, Chung EH, Weiner RB, Li H, Guseh JS. Circ Res. 2025 Jul 7;137(2):231-254. PMID: 40608857. Review.
Physiologic Phenotyping of Responses to Exercise and Activity in Heart Failure. Lewis GD, Tada A, Landsteiner I, Borlaug BA. Circ Res. 2025 Jul 7;137(2):290-315. PMID: 40608855. Review.
Exercise Mitigates Diabetic Cardiomyopathy by Suppressing Ferroptosis via N-Acetyltransferase 10. Shen S, Sugai-Munson A, Xiao X, Zhang Y, Kang J, Khetarpal SA, Jonas ER, Ambardekar AV, Bristow MR, Li H. Circ Res. 2025 Jul 7;137(2):354-356. PMID: 40492308.
Cardiac diffusion-weighted and tensor imaging: A consensus statement from the special interest group of the Society for Cardiovascular Magnetic Resonance. Dall’Armellina E, Ennis DB, Axel L, Croisille P, Ferreira PF, Gotschy A, Lohr D, Moulin K, Nguyen CT, Nielles-Vallespin S, Romero W, Scott AD, Stoeck C, Teh I, Tunnicliffe EM, Viallon M, Wang V, Young AA, Schneider JE, Sosnovik DE. J Cardiovasc Magn Reson. 2025 Summer;27(1):101109. PMID: 39442672.
Nonadherence to guidelines for genetic testing in families with ovarian cancer shows racial bias. Omorodion JO, Nathan A, Lipsitz S, Koyama S, Perez E, Green RC, Natarajan P, Gold NB. Genet Med. 2025 Jul;27(7):101444. PMID: 40260668.
Clonal hematopoiesis of indeterminate potential and incidence of venous thromboembolism in older adults. Saadatagah S, Kim RB, Sukumar S, Uddin MM, Folsom AR, Cushman M, Tang W, Natarajan P, Ballantyne CM, Lutsey PL, Li A. J Thromb Haemost. 2025 Jul;23(7):2235-2241. PMID: 40252845.
Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery. German J, Cordioli M, Tozzo V, Urbut S, Arumäe K, Smit RAJ, Lee J, Li JH, Janucik A, Ding Y, Akinkuolie A, Heyne HO, Eoli A, Saad C, Al-Sarraj Y, Abdel-Latif R, Mohammed S, Hail MA, Barry A, Wang Z, Cajuso T, Corbetta A, Natarajan P, Ripatti S, Philippakis A, Szczerbinski L, Pasaniuc B, Kutalik Z, Mbarek H, Loos RJF, Vainik U, Ganna A. Nat Med. 2025 Jul;31(7):2269-2276. PMID: 40251273.
Role of Lipoprotein(a) in Atherosclerotic Cardiovascular Disease in South Asian Individuals. Patel D, Koschinsky ML, Agarwala A, Natarajan P, Bhatia HS, Mehta A, Patel J, Peters M, Pandya S, Sagheer U, Puri R, Virani SS, Kalra DK. J Am Heart Assoc. 2025 Jul 15;14(14):eJAHA2024040361T. PMID: 40654252. Review.
Genomics reveals eleven obesity endotypes with distinct biological and phenotypic signatures. Kim MS, Song M, Kim H, Park S, Shim I, Lim S, Kim B, Chen X, Sui Y, Jemma Cho SM, Koyama S, Yun JS, Natarajan P, Ellinor PT, Fahed AC, Won HH. medRxiv [Preprint]. 2025 Jul 2:2025.06.30.25330607. PMID: 40630572.
Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk. Hu J, Ye Y, Zhang C, Ruan Y, Natarajan P, Zhao H. PLoS Comput Biol. 2025 Jun 26;21(6):e1013191. PMID: 40570042.
Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome. Limpitikul WB, Silverman MG, Valkov N, Park JG, Yeri A, Garcia FC, Li G, Gokulnath P, Garcia-Contreras M, Alsop E, Hutchins E, Spanos M, Lin C, Bomb K, Rosenzweig A, Kwong R, van-Keuren Jensen K, Januzzi JL Jr, Shah R, Morrow DA, Sabatine MS, Das S. Extracell Vesicle. 2025 Jun;5:100070. PMID: 40524753.
Differences in Arterial Events in Vascular Ehlers-Danlos, Loeys-Dietz, and Marfan Syndrome. Calderon-Martinez E, Velasco WV, Guo D, Hostetler EH, Xun Z, Stephens S, Shalhub S, De Backer J, Ouzounian M, LeMaire SA, Milleron O, Hanna N, Arnaud P, Tchitchinadze M, Prakash SK, Lindsay M, Marcadier J, Jeremy R, Morris SA, Yetman AT, Boileau C, Braverman AC, Jondeau G, Milewicz DM. J Am Coll Cardiol. 2025 Jun 24;85(24):2355-2367. PMID: 40533124.
Lanthanide Complexes-Doped Silica Nanoparticles for Dual-Modal Ratiometric Time-Gated Luminescence/Magnetic Resonance Imaging of Inflammatory Diseases. Ma H, Liu Q, Akam-Baxter EA, Huang Y, Yuan J, Huang H, Liu D, Song B. Anal Chem. 2025 Jun 17;97(23):12108-12115. PMID: 40470541.
Bench to all Bedsides in Genomics and Precision Medicine. Tcheandjieu C, Robinson C, Natarajan P. J Am Heart Assoc. 2025 Jun 3;14(11):e039202. PMID: 40417804.
Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation. Wijdeveld LFJM, Ajufo E, Challa SP, Rämö JT, Wang X, Kany S, Halford JL, Weng LC, Choi SH, Aragam KG, van Tintelen JP, Brundel BJJM, Jurgens SJ, Ellinor PT. JAMA Cardiol. 2025 Jun 1;10(6):564-573. PMID: 40305039.
Dissecting the Genetic Architecture of Intracranial Aneurysms. Adkar SS, Lynch J, Choi RB, Roychowdhury T, Judy RL, Paruchuri K, Go DC, Bamezai S, Cabot J, Sorondo S, Levin MG, Milewicz DM, Willer CJ, Natarajan P, Pyarajan S, Chang KM, Damrauer S, Tsao P, Skirboll S, Leeper NJ, Klarin D. Circ Genom Precis Med. 2025 Jun;18(3):e004626. PMID: 40255156.
Controversy in Hypertension: Pro-Side of the Argument Using Artificial Intelligence for Hypertension Diagnosis and Management. Armoundas AA, Ahmad FS, Attia ZI, Doudesis D, Khera R, Kyriakoulis KG, Stergiou GS, Tang WHW. Hypertension. 2025 Jun;82(6):929-944. PMID: 40091745. Review.
Impact of a clinical atrial fibrillation risk estimation tool on cardiac rhythm monitor utilization following acute ischemic stroke: A prepost. Ashburner JM, Tack RWP, Khurshid S, Turner AC, Atlas SJ, Singer DE, Ellinor PT, Benjamin EJ, Trinquart L, Lubitz SA, Anderson CD. Am Heart J. 2025 Jun;284:57-66. PMID: 39978665.
Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood. Gupta R, Durham TJ, Chau G, Uddin MM, Lu W, Karczewski KJ, Howrigan D, Natarajan P, Zhou W, Neale BM, Mootha VK. bioRxiv [Preprint]. 2025 May 28:2025.05.25.655566. PMID: 40501828.
Deciphering the gut microbiome’s metabolic code: pathways to bone health and novel therapeutic avenues. Hwang D, Chong E, Li Y, Li Y, Roh K. Front Endocrinol (Lausanne). 2025 May 22;16:1553655. PMID: 40475999. Review.
Recent Pathophysiological Insights Are Advancing the Treatment of Venous Thromboembolism. Singh S, Kumar P, Yadav SK, Jaffer FA, Reed GL. JACC Basic Transl Sci. 2025 May;10(5):689-703. PMID: 40436530. Review.
Genotype-Phenotype Low-Density Lipoprotein Cholesterol Discordance and Coronary Artery Disease Risk. Shankar A, Truong B, Koyama S, Paruchuri K, Patel A, Peloso GM, Hornsby W, Natarajan P. JACC Adv. 2025 May;4(5):101677. PMID: 40286383.
Small RNAs as therapeutic agents: From catalytic motifs to regulatory pathways. Rossi JJ, Das S. Mol Ther. 2025 May 7;33(5):2238-2242. PMID: 40181543. Review.
A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer. Tang L, Hill MC, He M, Chen J, Wang Z, Ellinor PT, Li M. Adv Sci (Weinh). 2025 May;12(19):e2408420. PMID: 40134047.
Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation. Kirmani S, Huan T, Van Amburg JC, Joehanes R, Uddin MM, Nguyen NQH, Yu B, Brody JA, Fornage M, Bressler J, Sotoodehnia N, Ong DA, Puddu F, Floyd JS, Ballantyne CM, Psaty BM, Raffield LM, Natarajan P, Conneely KN, Weinstock JS, Carson AP, Lange LA, Ferrier K, Heard-Costa NL, Murabito J, Bick AG, Levy D. Nat Commun. 2025 May 20;16(1):4678. PMID: 40393957.
Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3. Kotikalapudi N, Ramachandran D, Vieira D, Rubio WB, Gipson GR, Troncone L, Vestal K, Maridas DE, Rosen V, Yu PB, Thompson TB, Banks AS. Nat Commun. 2025 May 13;16(1):4432. PMID: 40360531.
Patient agency and large language models in worldwide encoding of equity. Armoundas AA, Loscalzo J. NPJ Digit Med. 2025 May 8;8(1):258. PMID: 40341689. Review.
Factors associated with medication adherence among young adults with hypertension. Kim E, Lee HH, Kim EJ, Cho SMJ, Kim HC, Lee H. Clin Hypertens. 2025 May 1;31:e18. PMID: 40336506.
Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global Biobanks. Levin MG, Koyama S, Woerner J, Zhang DY, Rodriguez A, Nandi T, Truong B, Abramowitz SA, Gupta H, Kamineni H, Hornsby W, Li Z, Cohron T, Huffman JE, Ellinor P, Kim D, Liao KP, Madduri RK, Voight BF, Verma A, Damrauer SM, Natarajan P. medRxiv [Preprint]. 2025 May 21:2025.04.18.25326074. PMID: 40313291.
Implementation of a Digital Disease Management Platform for Heart Failure: AMAZE. Paruchuri K, Bernardo R, Haidermota S, Lannery K, Finneran P, Wong M, Sanborn T, Joice M, Boyle-Kelly J, Silacci S, Hornsby W, Linganathan K, Olufade T, Januzzi JL Jr, Natarajan P. J Card Fail. 2025 May;31(5):863-867. PMID: 39743038.
Rare genetic variation in PTPRB is associated with central serous chorioretinopathy, varicose veins and glaucoma. Rämö JT, Gorman BR, Weng LC, Jurgens SJ, Singhanetr P, Tieger MG, van Dijk EH, Halladay CW, Wang X, Hauser BM, Kim SH, Brinks J, Choi SH, Luo Y; FinnGen; VA Million Veteran Program; Pyarajan S, Nealon CL, Gorin MB, Wu WC, Anthony SA, Roncone DP, Sobrin L, Kaarniranta K, Yzer S, Palotie A, Peachey NS, Turunen JA, Boon CJ, Ellinor PT, Iyengar SK, Daly MJ, Rossin EJ. Nat Commun. 2025 May 3;16(1):4127. PMID: 40319023.
Perspectives from Rising Stars at the R13 NIA/AGS Conference on Resilience Biomarkers. Umoh ME, Garcia-Contreras M, Cheung KL, Abadir P. J Am Geriatr Soc. 2025 Apr;73(4):1328-1330. PMID: 39481917.
Childhood HDL-C and Adult ASCVD: Mechanistic Insights and Preventive Implications. Ahmadizar F, Natarajan P, Paruchuri K. Eur J Prev Cardiol. 2025 Apr 25:zwaf265. PMID: 40275444.
Deciphering Clonal Hematopoiesis of Indeterminate Potential: Methods, Mechanisms, and Implications for Kidney Diseases. Yu Z, Vlasschaert C, Natarajan P. J Am Soc Nephrol. 2025 Apr 15;36(9):1867-1878. PMID: 40232845. Review.
Association of Clonal Hematopoiesis of Indeterminate Potential with Cardiovascular Events in Patients with CKD. Pan Y, Vlasschaert C, Rao V, Akwo EA, Hixson JE, Uddin MM, Yu Z, Kim DK, Bick A, Kestenbaum B, Chong M, Paré G, Rauh M, Levin A, Lash JP, Kurella Tamura M, Cohen DL, He J, Hamm L, Deo R, Bhat Z, Rao P, Xie D, Natarajan P, Kelly TN, Robinson-Cohen C, Lanktree MB; Canadian Study of Prediction of Death, Dialysis and Interim Cardiovascular Events (CanPREDDICT) and Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. J Am Soc Nephrol. 2025 Apr 9;36(9):1775-1785. PMID: 40202812.
Clonal Hematopoiesis of Indeterminate Potential and Progression of CKD. Vlasschaert C, Pan Y, Chen J, Akwo E, Rao V, Hixson JE, Chong M, Uddin MM, Yu Z, Jiang M, Peng F, Cao S, Wang Y, Kim DK, Hung AM, He J, Tamura MK, Cohen DL, He J, Li C, Bhat Z, Rao P, Xie D, Bick AG, Kestenbaum B, Paré G, Rauh MJ, Levin A, Natarajan P, Lash JP, Zhang MZ, Harris RC Jr, Robinson-Cohen C, Lanktree MB, Kelly TN; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. J Am Soc Nephrol. 2025 Apr 9;36(9):1764-1774. PMID: 40202794.
New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals. Kany S, Rämö JT, Playford D, Strange G, Hou C, Jurgens SJ, Nauffal V, Cunningham JW, Lau ES, Butte AJ, Ho JE, Olgin JE, Elmariah S, Lindsay ME, Chan YK, Stewart S, Ellinor PT, Pirruccello JP. J Am Coll Cardiol. 2025 Apr 8;85(13):1387-1399. PMID: 40175013.
Sex Hormones and Heart Failure Risk. Ebong IA, Appiah D, Mauricio R, Narang N, Honigberg MC, Ilonze OJ, Aggarwal NR, Zanni MV, Mohammed SF, Cho L, Michos ED; American College of Cardiology Cardiovascular Disease in Women Committee. JACC Adv. 2025 Apr;4(4):101650. PMID: 40088731. Review.
A novel swine model of chronic deep vein thrombosis (DVT) suitable for endovascular device assessment. Li W, Jaffer FA. Vasc Med. 2025 Apr;30(2):136-137. PMID: 40079774.
Predicting Atrial Fibrillation After Stroke by Combining Polygenic Risk Scores and Clinical Features. Tack RWP, Tan BYQ, Senff JR, Prapiadou S, Kimball TN, Khurshid S, Ashburner JM, Jurgens SJ, Singh SD, Weng LC, Gunn S, Roselli C, Lunetta KL, Benjamin EJ, Ellinor PT, Rosand J, Mayerhofer E, Lubitz SA, Anderson CD. Stroke. 2025 Apr;56(4):878-886. PMID: 39882610.
Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes. Ravi A, Koyama S, Cho SMJ, Haidermota S, Hornsby W, Ellinor PT, Natarajan P. JAMA Cardiol. 2025 Apr 1;10(4):379-383. PMID: 39813027.
The breadth and impact of the Global Lipids Genetics Consortium. Dron JS, Natarajan P, Peloso GM. Curr Opin Lipidol. 2025 Apr 1;36(2):61-70.PMID: 39602359. Review.
Rapid and robust generation of cardiomyocyte-specific crispants in zebrafish using the cardiodeleter system. Keeley S, Fernández-Lajarín M, Bergemann D, John N, Parrott L, Andrea BE, González-Rosa JM. Cell Rep Methods. 2025 Mar 24;5(3):101003. PMID: 40132543.
Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure. Latorre-Crespo E, Robertson NA, Kosebent EG, MacGillivray L, Murphy L, Uddin M, Whitsel E, Honigberg M, Bick A, Reiner AP, Orrù V, Marongiu M, Cucca F, Fiorillo E, Deary IJ, Harris S, Cox S, Marioni R, Schumacher L, Chandra T, Kirschner K. bioRxiv [Preprint]. 2025 Mar 3:2025.02.28.640879. PMID: 40093158.
Augmenting Primary Prevention of Sudden Cardiac Arrest in a Young Population. Cho SMJ, Yoo TH. J Am Heart Assoc. 2025 Mar 18;14(6):e040881. PMID: 40079325.
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk. Choi SH, Jurgens SJ, Xiao L, Hill MC, Haggerty CM, Sveinbjörnsson G, Morrill VN, Marston NA, Weng LC, Pirruccello JP, Arnar DO, Gudbjartsson DF, Mantineo H, von Falkenhausen AS, Natale A, Tveit A, Geelhoed B, Roselli C, Van Wagoner DR, Darbar D, Haase D, Soliman EZ, Davogustto GE, Jun G, Calkins H, Anderson JL, Brody JA, Halford JL, Barnard J, Hokanson JE, Smith JD, Bis JC, Young K, Johnson LSB, Risch L, Gula LJ, Kwee LC, Chaffin MD, Kühne M, Preuss M, Gupta N, Nafissi NA, Smith NL, Nilsson PM, van der Harst P, Wells QS, Judy RL, Schnabel RB, Johnson R, Smit RAJ, Gabriel S, Knight S, Furukawa T, Blackwell TW, Nauffal V, Wang X, Min YI, Yoneda ZT, Laksman ZWM, Bezzina CR, Alonso A, Psaty BM, Albert CM, Arking DE, Roden DM, Chasman DI, Rader DJ, Conen D, McManus DD, Fatkin D, Benjamin EJ, Boerwinkle E, Marcus GM, Christophersen IE, Smith JG, Roberts JD, Raffield LM, Shoemaker MB, Cho MH, Cutler MJ, Rienstra M, Chung MK, S Olesen M, Sinner MF, Sotoodehnia N, Kirchhof P, Loos RJF, Nazarian S, Mohanty S, Damrauer SM, Kaab S, Heckbert SR, Redline S, Shah SH, Tanaka T, Ebana Y; Regeneron Genetics Center; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Holm H, Stefansson K, Ruff CT, Sabatine MS, Lunetta KL, Lubitz SA, Ellinor PT. Nat Genet. 2025 Mar;57(3):548-562. PMID: 40050430.
Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Roselli C, Surakka I, Olesen MS, Sveinbjornsson G, Marston NA, Choi SH, Holm H, Chaffin M, Gudbjartsson D, Hill MC, Aegisdottir H, Albert CM, Alonso A, Anderson CD, Arking DE, Arnar DO, Barnard J, Benjamin EJ, Braunwald E, Brumpton B, Campbell A, Chami N, Chasman DI, Cho K, Choi EK, Christophersen IE, Chung MK, Conen D, Crijns HJ, Cutler MJ, Czuba T, Damrauer SM, Dichgans M, Dörr M, Dudink E, Duong T, Erikstrup C, Esko T, Fatkin D, Faul JD, Ferreira M, Freitag DF, Ganesh SK, Gaziano JM, Geelhoed B, Ghouse J, Gieger C, Giulianini F, Graham SE, Gudnason V, Guo X, Haggerty C, Hayward C, Heckbert SR, Hveem K, Ito K, Johnson R, Jukema JW, Jurgens SJ, Kääb S, Kane JP, Kany S, Kardia SLR, Kavousi M, Khurshid S, Kamanu FK, Kirchhof P, Kleber ME, Knight S, Komuro I, Krieger JE, Launer LJ, Li D, Lin H, Lin HJ, Loos RJF, Lotta L, Lubitz SA, Lunetta KL, Macfarlane PW, Magnusson PKE, Malik R, Mantineo H, Marcus GM, März W, McManus DD, Melander O, Melloni GEM, Meyre PB, Miyazawa K, Mohanty S, Monfort LM, Müller-Nurasyid M, Nafissi NA, Natale A, Nazarian S, Ostrowski SR, Pak HN, Pang S, Pedersen OB, Pedersen NL, Pereira AC, Pirruccello JP, Preuss M, Psaty BM, Pullinger CR, Rader DJ, Rämö JT, Ridker PM, Rienstra M, Risch L, Roden DM, Rotter JI, Sabatine MS, Schunkert H, Shah SH, Shim J, Shoemaker MB, Simonson B, Sinner MF, Smit RAJ, Smith JA, Smith NL, Smith JG, Soliman EZ, Sørensen E, Sotoodehnia N, Strbian D, Stricker BH, Teder-Laving M, Sun YV, Thériault S, Thorolfsdottir RB, Thorsteinsdottir U, Tveit A, van der Harst P, van Meurs J, Wang B, Weiss S, Wells QS, Weng LC, Wilson PW, Xiao L, Yang PS, Yao J, Yoneda ZT, Zeller T, Zeng L, Zhao W, Zhou X, Zöllner S; BioBank Japan Project; Regeneron Genetics Center; DBDS Genomic Consortium; Ruff CT, Bundgaard H, Willer C, Stefansson K, Ellinor PT. Nat Genet. 2025 Mar;57(3):539-547. PMID: 40050429.
Analysis of human urinary extracellular vesicles reveals disordered renal metabolism in myotonic dystrophy type 1. Kumari P, Sullivan LM, Li Z, Parker Conquest E, Cornforth E, Jayakumar R, Hu N, Alexander Sizemore J, McKee BB, Kitchen RR, González-Pérez P, Linville C, Castro K, Gutierrez H, Samaan S, Townsend EL, Darras BT, Rutkove SB, Iannaccone ST, Clemens PR, Puwanant A, Das S, Wheeler TM. Nat Commun. 2025 Mar 5;16(1):2158. PMID: 40044661.
Impact of Social Determinants of Health on Cardiovascular Disease. Bazoukis G, Loscalzo J, Hall JL, Bollepalli SC, Singh JP, Armoundas AA. J Am Heart Assoc. 2025 Mar 4;14(5):e039031. PMID: 40035388. Review.
Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive lipid lowering. Marston NA, Kamanu FK, Melloni GEM, Schnitzler G, Hakim A, Ma RX, Kang H, Chasman DI, Giugliano RP, Ellinor PT, Ridker PM, Engreitz JM, Sabatine MS, Ruff CT, Gupta RM. Nat Med. 2025 Mar;31(3):963-969. PMID: 40011692.
Genome-Wide Association Study for Resting Electrocardiogram in the Qatari Population Identifies 6 Novel Genes and Validates Novel Polygenic Risk Scores. Khan N, Shaar A, Kunji K, Khan A, Elshrif M, Bashir M, Ali MT, Al Haj Zen A, Kiryluk K, Nemer G, Fahed AC, Saad M. J Am Heart Assoc. 2025 Mar 4;14(5):e038341. PMID: 40008532.
“Weekend Warrior” Physical Activity and Adipose Tissue Deposition. Kany S, Al-Alusi MA, Rämö JT, Pirruccello JP, Ajufo E, Churchill TW, Lubitz SA, Maddah M, Guseh JS, Ellinor PT, Khurshid S. JACC Adv. 2025 Mar;4(3):101603. PMID: 39954344.
East and South Asian-Specific Blood Pressure Trajectories and Cardiovascular Disease. Cho SMJ, Urbut S, Ruan Y, Bhatnagar A, Ganesh S, Hornsby WE, Bhattacharya R, Honigberg MC, Juraschek SP, Yang E, Shimbo D, Natarajan P. Hypertension. 2025 Mar;82(3):520-531. PMID: 39936320.
Type 2 diabetes genetic risk and incident diabetes across diabetes risk enhancers. Moura FA, Kamanu FK, Wiviott SD, Giugliano RP, Udler MS, Florez JC, Ellinor PT, Sabatine MS, Ruff CT, Marston NA. Diabetes Obes Metab. 2025 Mar;27(3):1287-1295. PMID: 39696834.
A deep learning digital biomarker to detect hypertension and stratify cardiovascular risk from the electrocardiogram. Al-Alusi MA, Friedman SF, Kany S, Rämö JT, Pipilas D, Singh P, Reeder C, Khurshid S, Pirruccello JP, Maddah M, Ho JE, Ellinor PT. NPJ Digit Med. 2025 Feb 22;8(1):120. PMID: 39987256.
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies. Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Jiang MZ, DiCorpo D, Gaynor SM, Dey R, Arnett DK, Benjamin EJ, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly TN, Konigsberg I, Kooperberg C, Kral BG, Li C, Li Y, Lin H, Liu CT, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Mitchell BD, Montasser ME, Morrison AC, Naseri T, North KE, Palmer ND, Peyser PA, Psaty BM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari HK, Vasan RS, Viali S, Wang Z, Wessel J, Yanek LR, Yu B; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Dupuis J, Meigs JB, Auer PL, Raffield LM, Manning AK, Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X. Nat Comput Sci. 2025 Feb;5(2):125-143. PMID: 39920506.
Ultrasound-Guided Nerve Hydrodissection for the Management of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis. Lee K, Park JM, Yoon SY, Kim MS, Kim YW, Shin JI, Lee SC. Yonsei Med J. 2025 Feb;66(2):111-120. PMID: 39894044.
Neurobiological Mechanisms Link Bipolar Disorder to Cardiovascular Disease: A Retrospective Biobank Study of Adverse Event Risk and Contributory Mechanisms. Baek JH, Grewal SS, Karam KA, Hanlon ER, Abohashem S, Seligowski AV, Henry M, Osborne MT, Nierenberg AA, Tawakol A. Bipolar Disord. 2025 Feb;27(1):57-66. PMID: 39888254.
Visions by WIMIN: Imposter Phenomenon. Akam-Baxter E, O’Brien CM, Sinharay S, Clavijo-Jordan V, Rodriguez SB, Ijoma JN, Kustagi A, Sahn M, Diop F, Mack K, Malonza N, Alvarez NH. Mol Imaging Biol. 2025 Feb;27(1):17-22. PMID: 39777596.
Decoration of Autophagy Detecting Nanoparticle with an Anionic Fluorochrome Enhances Multispectral Characterization of Autophagosome Location and Flux. Akam-Baxter E, Chen HH, Boukhalfa A, Yu A, Ling LA, Kung AH, Bulnes Rodriguez S, Yuan H, Josephson L, Sosnovik DE. Small. 2025 Feb;21(6):e2407915. PMID: 39723734.
Accelerometer-Measured Sedentary Behavior and Risk of Future Cardiovascular Disease. Ajufo E, Kany S, Rämö JT, Churchill TW, Guseh JS, Aragam KG, Ellinor PT, Khurshid S. J Am Coll Cardiol. 2025 Feb 11;85(5):473-486. PMID: 39545903.
Polygenic risk, aspirin, and primary prevention of coronary artery disease. Yu C, Natarajan P, Patel AP, Bhatia HS, Khera AV, Neumann JT, Tsimikas S, Wolfe R, Nicholls SJ, Reid CM, Zoungas S, Tonkin AM, McNeil JJ, Lacaze P. Eur Heart J Cardiovasc Pharmacother. 2025 Feb 8;11(1):84-91. PMID: 39455425.
First-in-human Evaluation of Safety and Dosimetry of [⁶⁴Cu]FBP8: A fibrin-binding PET Probe. Izquierdo-Garcia D, Désogère P, Philip AL, Sosnovik DE, Catana C, Caravan P. Mol Imaging Biol. 2025 Feb;27(1):99-108. PMID: 39633070.
Opportunistic Assessment of Cardiovascular Risk Using Ai-Derived Structural Aortic and Cardiac Phenotypes From Non-Contrast Chest Computed Tomography. Oo DW, Sturniolo A, Jung M, Langenbach M, Foldyna B, Kiel DP, Aerts HJ, Natarajan P, Lu MT, Raghu VK. medRxiv [Preprint]. 2025 Jan 29:2025.01.28.25321302. PMID: 39974056.
Genetic Predisposition to Coronary Artery Disease: Evaluating Statin Therapy in Elder Populations From PROSPER. Choi SH, Young R, Koyama S, Jukema JW, Trompet S, Ford I, Natarajan P, Peloso GM. JACC Adv. 2025 Jan 8;4(2):101535. PMID: 39886309.
Longitudinal Evaluation of Genetic Hypertrophic Cardiomyopathy Penetrance and Transition to Disease in an Academic Biobank. Shin JY, Small AM, Blout Zawatsky CL, Fifer MA, Tower-Rader A, Green RC, Lebo M, Natarajan P. JACC Adv. 2025 Jan 8;4(2):101520. PMID: 39886308.
Breaking binary in cardiovascular disease risk prediction. Zhang Y, Fahed AC. NPJ Cardiovasc Health. 2025 Jan 13;2(1):2. PMID: 41776352. Review.
Unsupervised deep learning of electrocardiograms enables scalable human disease profiling. Friedman SF, Khurshid S, Venn RA, Wang X, Diamant N, Di Achille P, Weng LC, Choi SH, Reeder C, Pirruccello JP, Singh P, Lau ES, Philippakis A, Anderson CD, Maddah M, Batra P, Ellinor PT, Ho JE, Lubitz SA. NPJ Digit Med. 2025 Jan 12;8(1):23. PMID: 39799251.
The impact of common and rare genetic variants on bradyarrhythmia development. Weng LC, Rämö JT, Jurgens SJ, Khurshid S, Chaffin M, Hall AW, Morrill VN, Wang X, Nauffal V, Sun YV, Beer D, Lee S, Nadkarni GN, Duong T, Wang B, Czuba T, Austin TR, Yoneda ZT, Friedman DJ, Clayton A, Hyman MC, Judy RL, Skanes AC, Orland KM, Treu TM, Oetjens MT, Alonso A, Soliman EZ, Lin H, Lunetta KL, van der Pals J, Issa TZ, Nafissi NA, May HT, Leong-Sit P, Roselli C, Choi SH; FinnGen; Million Veteran Program; Regeneron Genetics Center; Khan HR, Knight S, Karlsson Linnér R, Bezzina CR, Ripatti S, Heckbert SR, Gaziano JM, Loos RJF, Psaty BM, Smith JG, Benjamin EJ, Arking DE, Rader DJ, Shah SH, Roden DM, Damrauer SM, Eckhardt LL, Roberts JD, Cutler MJ, Shoemaker MB, Haggerty CM, Cho K, Palotie A, Wilson PWF, Ellinor PT, Lubitz SA. Nat Genet. 2025 Jan;57(1):53-64. PMID: 39747593.
Association between genetically predicted leisure and social activities and cardiovascular disease and other health outcomes. Kim S, Ko H, Myung W, Yoon J, Kim K, Jung SH, Shim I, Cha S, Kim B, Kang JM, Park WY, Natarajan P, Do R, Won HH. Nat Cardiovasc Res. 2025 Jan;4(1):15-25. PMID: 39747453.
Collagen Pyridinoline Cross-Links Are Absent in Reversible Myocardial Fibrosis. Akam-Baxter E, Ridley SJ, Moon BF, Caravan P, Sosnovik DE. Circ Res. 2025 Jan 31;136(3):315-317. PMID: 39717913.
Venous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia. Pabon MA, Weisbrod RM, Castro C, Li H, Xia P, Kang J, Ardissino M, Economy KE, Yang Z, Shi Y, Kim E, Perillo A, Barrett L, Brown JM, Divakaran S, Cetinbas M, Sadreyev RI, de Marvao A, Wood MJ, Scott NS, Lau ES, Ho JE, Di Carli MF, Roh JD, Hamburg NM, Honigberg MC. Circ Res. 2025 Jan 17;136(2):180-190. PMID: 39727051.
Transcriptional profile of the rat cardiovascular system at single-cell resolution. Arduini A, Fleming SJ, Xiao L, Hall AW, Akkad AD, Chaffin MD, Bendinelli KJ, Tucker NR, Papangeli I, Mantineo H, Flores-Bringas P, Babadi M, Stegmann CM, García-Cardeña G, Lindsay ME, Klattenhoff C, Ellinor PT. Cell Rep. 2025 Jan 28;44(1):115091. PMID: 39709602.
Cardiopulmonary Exercise Testing in Advanced Heart Failure Management. Landsteiner I, Ikoma T, Lewis GD. Heart Fail Clin. 2025 Jan;21(1):35-49. PMID: 39550079. Review.
How the brain impacts the heart: lessons from ischaemic stroke and other neurological disorders. Stengl H, Poller WC, Di Vece D, Templin C, Endres M, Nolte CH, Scheitz JF. Heart. 2025 Jan 13;111(3):99-108. PMID: 39515993. Review.
Cause-specific death in adults with type 1 diabetes and type 2 diabetes: Insights from the UK Biobank. Ostrominski JW, Cho SMJ, Vaduganathan M, Honigberg MC. Diabetes Obes Metab. 2025 Jan;27(1):422-427. PMID: 39402726.
Gain-of-function variants in SMAD4 compromise respiratory epithelial function. Lindsay ME, Scimone ER, Lawton J, Richa R, Yonker LM, Di YP, Buch K, Ouyang W, Mo X, Lin AE, Mou H. J Allergy Clin Immunol. 2025 Jan;155(1):107-119.e2. PMID: 39243984.

2024

His-Ventricular Interval and Incident Pacemaker Implant in Over 3000 Ambulatory Patients Undergoing Invasive Electrophysiologic Procedures. Pipilas D, Sommers T, Michaud GF, Ellinor PT, Khurshid S. Circ Arrhythm Electrophysiol. 2024 Dec;17(12):e013285. PMID: 39601164.
Clonal Hematopoiesis and Risk of Heart Failure After Autologous Hematopoietic Cell Transplantation for Lymphoma. Rhee JW, Pillai R, Chen S, Bosworth A, Oganesyan A, Atencio L, Freeman K, Estrada C, Guzman T, Lukas K, Peng K, Sigala B, Lukuridze A, Lindenfeld L, Jamal F, Natarajan P, Bhatia S, Herrera AF, Mei MG, Nakamura R, Wong FL, Forman SJ, Armenian SH. JACC CardioOncol. 2024 Dec 3;7(1):20-33. PMID: 39896122.
Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience. Jurgens SJ, Rämö JT, Kramarenko DR, Wijdeveld LFJM, Haas J, Chaffin MD, Garnier S, Gaziano L, Weng LC, Lipov A, Zheng SL, Henry A, Huffman JE, Challa S, Rühle F, Verdugo CD, Krijger Juárez C, Kany S, van Orsouw CA, Biddinger K, Poel E, Elliott AL, Wang X, Francis C, Ruan R, Koyama S, Beekman L, Zimmerman DS, Deleuze JF, Villard E, Trégouët DA, Isnard R; FinnGen; VA Million Veteran Program; HERMES Consortium; Boomsma DI, de Geus EJC, Tadros R, Pinto YM, Wilde AAM, Hottenga JJ, Sinisalo J, Niiranen T, Walsh R, Schmidt AF, Choi SH, Chang KM, Tsao PS, Matthews PM, Ware JS, Lumbers RT, van der Crabben S, Laukkanen J, Palotie A, Amin AS, Charron P, Meder B, Ellinor PT, Daly M, Aragam KG, Bezzina CR. Nat Genet. 2024 Dec;56(12):2636-2645. PMID: 39572784.
Integrative proteomic analyses across common cardiac diseases yield mechanistic insights and enhanced prediction. Schuermans A, Pournamdari AB, Lee J, Bhukar R, Ganesh S, Darosa N, Small AM, Yu Z, Hornsby W, Koyama S, Kooperberg C, Reiner AP, Januzzi JL, Honigberg MC, Natarajan P. Nat Cardiovasc Res. 2024 Dec;3(12):1516-1530. PMID: 39572695.
Publisher Correction: Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience. Jurgens SJ, Rämö JT, Kramarenko DR, Wijdeveld LFJM, Haas J, Chaffin MD, Garnier S, Gaziano L, Weng LC, Lipov A, Zheng SL, Henry A, Huffman JE, Challa S, Rühle F, Verdugo CD, Krijger Juárez C, Kany S, van Orsouw CA, Biddinger K, Poel E, Elliott AL, Wang X, Francis C, Ruan R, Koyama S, Beekman L, Zimmerman DS, Deleuze JF, Villard E, Trégouët DA, Isnard R; FinnGen; VA Million Veteran Program; HERMES Consortium; Boomsma DI, de Geus EJC, Tadros R, Pinto YM, Wilde AAM, Hottenga JJ, Sinisalo J, Niiranen T, Walsh R, Schmidt AF, Choi SH, Chang KM, Tsao PS, Matthews PM, Ware JS, Lumbers RT, van der Crabben S, Laukkanen J, Palotie A, Amin AS, Charron P, Meder B, Ellinor PT, Daly M, Aragam KG, Bezzina CR. Nat Genet. 2024 Dec;56(12):2843. PMID: 39633063.
Author Correction: Genetic drivers and cellular selection of female mosaic X chromosome loss. Liu A, Genovese G, Zhao Y, Pirinen M, Zekavat SM, Kentistou KA, Yang Z, Yu K, Vlasschaert C, Liu X, Brown DW, Hudjashov G, Gorman BR, Dennis J, Zhou W, Momozawa Y, Pyarajan S, Tuzov V, Pajuste FD, Aavikko M, Sipilä TP, Ghazal A, Huang WY, Freedman ND, Song L, Gardner EJ; FinnGen; Estonian Biobank Research Team; Breast Cancer Association Consortium; Million Veteran Program; Sankaran VG, Palotie A, Ollila HM, Tukiainen T, Chanock SJ, Mägi R, Natarajan P, Daly MJ, Bick A, McCarroll SA, Terao C, Loh PR, Ganna A, Perry JRB, Machiela MJ. Nature. 2024 Dec;636(8043):E7. PMID: 39627447.
Polygenic Prediction of Recurrent Events After Early-Onset Myocardial Infarction. Ardissino M, Paraboschi EM, Lambert SA, Kim LG, Kelemen M, Maglietta G, Crocamo A, Magnani G, Bricoli S, Vignali L, Niccoli G, Tubaro M, Pastika L, Sau A, Ng FS, de Marvao A, Honigberg MC, Natarajan P, Nelson AJ, Inouye M, Di Angelantonio E, Asselta R, Ardissino D, Butterworth AS. Circ Genom Precis Med. 2024 Dec;17(6):e004687. PMID: 39611259.
Interpretation and classification of FBN1 variants associated with Marfan syndrome: consensus recommendations from the Clinical Genome Resource’s FBN1 variant curation expert panel. Drackley A, Somerville C, Arnaud P, Baudhuin LM, Hanna N, Kluge ML, Kotzer K, Boileau C, Bronicki L, Callewaert B, Cecchi A, Dietz H, Guo D, Harris S, Jarinova O, Lindsay M, Little L, Loeys B, MacCarrick G, Meester J, Milewicz D, Morisaki T, Morisaki H, Murdock D, Renard M, Richer J, Robert L, Ouzounian M, Van Laer L, De Backer J, Muiño-Mosquera L. Genome Med. 2024 Dec 31;16(1):154. PMID: 39741318.
Gestational diabetes and cardiovascular disease: lessons for primordial prevention in women and for interpreting Mendelian randomization studies. Ardissino M, Honigberg MC. Eur Heart J. 2024 Dec 23;45(48):5168-5170. PMID: 39523567.
Classification of Myocardial Infarction in Women With Hypertensive Disorders of Pregnancy. Honigberg MC. J Am Coll Cardiol. 2024 Dec 3;84(23):2275-2277. PMID: 39503655.
Artificial Intelligence Algorithms in Cardiovascular Medicine: An Attainable Promise to Improve Patient Outcomes or an Inaccessible Investment? Bota P, Thambiraj G, Bollepalli SC, Armoundas AA. Curr Cardiol Rep. 2024 Dec;26(12):1477-1485. PMID: 39470943 Review.
Tuning Into Immune Cell Responses of Chronic Stress With Intravital Microscopy. Nahrendorf M. Arterioscler Thromb Vasc Biol. 2024 Dec;44(12):2507-2508. PMID: 39445423.
Integration of observational and causal evidence for the association between adiposity and 17 gastrointestinal outcomes: An umbrella review and meta-analysis. Kim MS, Lee I, Natarajan P, Do R, Kwon Y, Shin JI, Solmi M, Kim JY, Won HH, Park S. Obes Rev. 2024 Dec;25(12):e13823. PMID: 39233338.
Development of a fibrin-targeted theranostic for gastric cancer. Esfahani SA, Ma L, Krishna S, Ma H, Raheem SJ, Shuvaev S, Rotile NJ, Weigand-Whittier J, Boice AT, Borges N, Treaba CA, Deffler C, Diyabalanage H, Humblet V, Sosnovik DE, Mahmood U, Heidari P, Shih A, Catana C, Strickland MR, Klempner SJ, Caravan P. Sci Transl Med. 2024 Dec 11;16(777):eadn7218. PMID: 39661705.
A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver. Perry AS, Hadad N, Chatterjee E, Jimenez-Ramos M, Farber-Eger E, Roshani R, Stolze LK, Betti MJ, Zhao S, Huang S, Martens L, Kendall TJ, Thone T, Amancherla K, Bailin S, Gabriel CL, Koethe J, Carr JJ, Terry JG, Vaitinadin NS, Freedman JE, Tanriverdi K, Alsop E, Van Keuren-Jensen K, Sauld JFK, Mahajan G, Khan SS, Colangelo L, Nayor M, Fisher-Hoch S, McCormick JB, North KE, Below JE, Wells QS, Abel ED, Kalhan R, Scott C, Guilliams M, Gamazon ER, Fallowfield JA, Banovich NE, Das S, Shah R. Cell Rep Med. 2024 Dec 17;5(12):101871. PMID: 39657669.
Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque. Nurmohamed NS, Shim I, Gaillard EL, Ibrahim S, Bom MJ, Earls JP, Min JK, Planken RN, Choi AD, Natarajan P, Stroes ESG, Knaapen P, Reeskamp LF, Fahed AC. JACC Cardiovasc Imaging. 2024 Dec;17(12):1445-1459. PMID: 39152960.
Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome. Park S, Kim S, Kim B, Kim DS, Kim J, Ahn Y, Kim H, Song M, Shim I, Jung SH, Cho C, Lim S, Hong S, Jo H, Fahed AC, Natarajan P, Ellinor PT, Torkamani A, Park WY, Yu TY, Myung W, Won HH. Nat Genet. 2024 Nov;56(11):2380-2391. PMID: 39349817.
Sociodemographic disparities in cardiovascular mortality by self-rated physical health: A U.S. nationwide county-level analysis. Munir M, Aldosoky W, Saif R, Sayed A, Bagga A, Kittaneh A, Elbanna M, Dar T, Abohashem S. Public Health. 2024 Nov;236:404-411. PMID: 39305658.
Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation. Hill MC, Simonson B, Roselli C, Xiao L, Herndon CN, Chaffin M, Mantineo H, Atwa O, Bhasin H, Guedira Y, Bedi KC Jr, Margulies KB, Klattenhoff CA, Tucker NR, Ellinor PT. Nat Commun. 2024 Nov 19;15(1):10002. PMID: 39562555.
Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis. Li Y, Xu W, Cheng Y, Djenoune L, Zhuang C, Cox AL, Britto CJ, Yuan S, Wang S, Sun Z. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2402818121. PMID: 39541357.
Strong Genes: Insights Into Polygenic Risk and Coronary Artery Calcium in Older Individuals. Patel AP. Circ Cardiovasc Imaging. 2024 Nov;17(11):e017531. PMID: 39534955.
Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: JACC Advances Expert Panel. Crousillat D, Sarma A, Wood M, Naderi S, Leon K, Gibson CM, Aday A, Grodzinsky A, Izard K, Kovacic JC, Lindsay ME, Phelan D, Rodriguez-Lozano PF, Scott NS, Scherer M, Sharma A, Sweis R, Sumner JA, Kim ESH. JACC Adv. 2024 Nov 20;3(12):101385. PMID: 39635541. Review.
Rare Genetic Variants in LDLR, APOB, and PCSK9 Are Associated With Aortic Stenosis. Rämö JT, Jurgens SJ, Kany S, Choi SH, Wang X, Smirnov AN, Friedman SF, Maddah M, Khurshid S, Ellinor PT, Pirruccello JP. Circulation. 2024 Nov 26;150(22):1767-1780. PMID: 39222019.
Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis. Zuriaga MA, Yu Z, Matesanz N, Truong B, Ramos-Neble BL, Asensio-López MC, Uddin MM, Nakao T, Niroula A, Zorita V, Amorós-Pérez M, Moro R, Ebert BL, Honigberg MC, Pascual-Figal D, Natarajan P, Fuster JJ. Eur Heart J. 2024 Nov 14;45(43):4601-4615. PMID: 39212933.
JAK2-mutant clonal hematopoiesis is associated with venous thromboembolism. Zon RL, Sekar A, Clapham K, Oren O, Niroula A, Bick AG, Gibson CJ, Griffin G, Uddin MM, Neuberg D, Natarajan P, Ebert BL. Blood. 2024 Nov 14;144(20):2149-2154. PMID: 39102652.
Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV. Schnittman SR, Talathi R, Wilks MQ, Hedgire S, Lu MT, Fourman LT, Alagpulinsa DA, Stockman SL, White KS, Wallis ZK, Autissier P, Stanley TL, Lee H, Honigberg MC, El-Fakhri G, Williams KC, Zanni MV, Grinspoon SK, Toribio M. AIDS. 2024 Nov 15;38(14):1940-1946. PMID: 38905489.
Glucagon-like Peptide-1 Receptor Agonists in the Context of Pathophysiology of Diverse Heart Failure with Preserved Ejection Fraction Phenotypes: Potential Benefits and Mechanisms of Action. Bykova A, Serova M, Chashkina M, Kosharnaya R, Salpagarova Z, Andreev D, Giverts I. Card Fail Rev. 2024 Oct 16;10:e14. PMID: 39507374. Review.
EV-idence uncovered: kidney-on-chip study links circulating EVs of cardiorenal syndrome to renal pathology. Ndiaye H, Rajput S, Sauld JFK, Mahajan G, Das S, Chatterjee E. Extracell Vesicles Circ Nucl Acids. 2024 Oct 26;5(4):574-579.PMID: 39811731.
Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries. Schuermans A, Santens B, den Eynde JV, Jacquemyn X, der Palen RLFV, Honigberg MC, Van De Bruaene A, Claus P, Bogaert J, Budts W. Int J Cardiol Congenit Heart Dis. 2024 Oct 23;18:100550. PMID: 39713235.
Population-specific putative causal variants shape quantitative traits. Koyama S, Liu X, Koike Y, Hikino K, Koido M, Li W, Akaki K, Tomizuka K, Ito S, Otomo N, Suetsugu H, Yoshino S, Akiyama M, Saito K, Ishikawa Y, Benner C, Natarajan P, Ellinor PT, Mushiroda T, Horikoshi M, Ikeda M, Iwata N, Matsuda K; Biobank Japan Project; Niida S, Ozaki K, Momozawa Y, Ikegawa S, Takeuchi O, Ito K, Terao C. Nat Genet. 2024 Oct;56(10):2027-2035. PMID: 39363016.
An Ounce of Prevention for a Pound of Cure?: Lipid-Lowering Therapy for Premature Coronary Disease. Khurshid S, Kany S. JACC Adv. 2024 Oct 16;4(1):101315. PMID: 39811757.
Associations of “Weekend Warrior” Physical Activity With Incident Disease and Cardiometabolic Health. Kany S, Al-Alusi MA, Rämö JT, Pirruccello JP, Churchill TW, Lubitz SA, Maddah M, Guseh JS, Ellinor PT, Khurshid S. Circulation. 2024 Oct 15;150(16):1236-1247. PMID: 39324186.
Electrocardiogram-Based Artificial Intelligence to Discriminate Cardioembolic Stroke and Stratify Risk of Atrial Fibrillation After Stroke. Khurshid S, Friedman SF, Kany S, Mahajan R, Turner AC, Lubitz SA, Maddah M, Ellinor PT, Anderson CD. Circ Arrhythm Electrophysiol. 2024 Oct;17(10):e012959. PMID: 39193715.
Epicardial and Pericardial Fat-Separated But Under the Same Roof-Reply. Rämö JT, Ellinor PT, Pirruccello JP. JAMA Cardiol. 2024 Oct 1;9(10):949-950. PMID: 39141398.
Cardiorenal Outcomes in Middle-Aged and Older Adults With Type 1 and Type 2 Diabetes. Ostrominski JW, Jemma Cho SM, Vaduganathan M, Honigberg MC. J Am Coll Cardiol. 2024 Oct 1;84(14):1363-1366. PMID: 39140954.
The AORTA Gene score for detection and risk stratification of ascending aortic dilation. Pirruccello JP, Khurshid S, Lin H, Weng LC, Zamirpour S, Kany S, Raghavan A, Koyama S, Vasan RS, Benjamin EJ, Lindsay ME, Ellinor PT. Eur Heart J. 2024 Oct 21;45(40):4318-4332. PMID: 39132911.
Proteome- and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia. Ardissino M, Truong B, Slob EAW, Schuermans A, Yoshiji S, Morley AP, Burgess S, Ng FS, de Marvao A, Natarajan P, Nicolaides K, Gaziano L, Butterworth A, Honigberg MC. Circ Genom Precis Med. 2024 Oct;17(5):e004755. PMID: 39119725.
Electronic physician notification to facilitate the recognition and management of severe aortic stenosis: Rationale, design, and methods of the randomized controlled DETECT AS trial. Abou-Karam R, Tanguturi V, Cheng F, Elmariah S. Am Heart J. 2024 Oct;276:39-48. PMID: 38950668.
Clusters of multidimensional exercise response patterns and estimated heart failure risk in the Framingham Heart Study. Miller PE, Gajjar P, Mitchell GF, Khan SS, Vasan RS, Larson MG, Lewis GD, Shah RV, Nayor M. ESC Heart Fail. 2024 Oct;11(5):3279-3289. PMID: 38943268.
Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans. Tahir UA, Barber JL, Cruz DE, Kars ME, Deng S, Tuftin B, Gillman MG, Benson MD, Robbins JM, Chen ZZ, Rao P, Katz DH, Farrell L, Sofer T, Hall ME, Ekunwe L, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Guo X, Chen YI, Manichaikul AW, Jain D; NHLBI Trans-Omics for Precision Medicine Consortium; Wang TJ, Reiner AP, Natarajan P, Itan Y, Rich SS, Rotter JI, Wilson JG, Raffield LM, Gerszten RE. J Clin Invest. 2024 Sep 24;134(21):e181802. PMID: 39316441.
Exome wide association study for blood lipids in 1,158,017 individuals from diverse populations. Koyama S, Yu Z, Choi SH, Jurgens SJ, Selvaraj MS, Klarin D, Huffman JE, Clarke SL, Trinh MN, Ravi A, Dron JS, Spinks C, Surakka I, Bhatnagar A, Lannery K, Hornsby W, Damrauer SM, Chang KM, Lynch JA, Assimes TL, Tsao PS, Rader DJ, Cho K, Peloso GM, Ellinor PT, Sun YV, Wilson PW, Program MV, Natarajan P. medRxiv. [Preprint]. 2024 Sep 18:2024.09.17.24313718. PMID: 39371182.
Cardiomyocyte-derived circulating extracellular vesicles allow a non-invasive liquid biopsy of myocardium in health and disease. Spanos M, Gokulnath P, Li G, Hutchins E, Meechoovet B, Sheng Q, Chatterjee E, Sharma R, Carnel-Amar N, Lin C, Azzam C, Ghaeli I, Amancherla KV, Victorino JF, Garcia-Mansfield K, Pfeffer R, Sahu P, Lindman BR, Elmariah S, Gamazon ER, Betti MJ, Bledsoe X, Lance ML, Absi T, Su YR, Do N, Contreras MG, Varrias D, Kladas M, Radulovic M, Tsiachris D, Spanos A, Tsioufis K, Ellinor PT, Tucker NR, Januzzi JL, Pirrotte P, Jovanovic-Talisman T, Van Keuren-Jensen K, Shah R, Das S. medRxiv. [Preprint]. 2024 Sep 22:2024.09.19.24314009. PMID: 39371135.
Improving Cardiovascular Disease Primary Prevention Treatment Thresholds in a New England Health Care System. Cho SMJ, Rivera R, Koyama S, Kim MS, Ganesh S, Bhattacharya R, Paruchuri K, Masson P, Honigberg MC, Allen NB, Hornsby W, Natarajan P. JACC Adv. 2024 Sep 6;3(10):101257. PMID: 39290815.
Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy. DeForest N, Wang Y, Zhu Z, Dron JS, Koesterer R, Natarajan P, Flannick J, Amariuta T, Peloso GM, Majithia AR. Nat Commun. 2024 Sep 14;15(1):8068. PMID: 39277575.
Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis. Uddin MM, Saadatagah S, Niroula A, Yu B, Hornsby WE, Ganesh S, Lannery K, Schuermans A, Honigberg MC, Bick AG, Libby P, Ebert BL, Ballantyne CM, Natarajan P. Nat Commun. 2024 Sep 9;15(1):7858. PMID: 39251642.
Targeting Fibrinolytic Inhibition for Venous Thromboembolism Treatment: Overview of an Emerging Therapeutic Approach. Singh S, Kumar P, Padwad YS, Jaffer FA, Reed GL. Circulation. 2024 Sep 10;150(11):884-898. PMID: 39250537. Review.
Rare coding variant analysis for human diseases across biobanks and ancestries. Jurgens SJ, Wang X, Choi SH, Weng LC, Koyama S, Pirruccello JP, Nguyen T, Smadbeck P, Jang D, Chaffin M, Walsh R, Roselli C, Elliott AL, Wijdeveld LFJM, Biddinger KJ, Kany S, Rämö JT, Natarajan P, Aragam KG, Flannick J, Burtt NP, Bezzina CR, Lubitz SA, Lunetta KL, Ellinor PT. Nat Genet. 2024 Sep;56(9):1811-1820. PMID: 39210047.
Clonal hematopoiesis, cardiovascular events and treatment benefit in 63,700 individuals from five TIMI randomized trials. Marston NA, Pirruccello JP, Melloni GEM, Kamanu F, Bonaca MP, Giugliano RP, Scirica BM, Wiviott SD, Bhatt DL, Steg PG, Raz I, Braunwald E, Libby P, Ellinor PT, Bick AG, Sabatine MS, Ruff CT. Nat Med. 2024 Sep;30(9):2641-2647. PMID: 39107561.
Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy. Wyant GA, Jiang Q, Singh M, Qayyum S, Levrero C, Maron BA, Kaelin WG Jr. Circulation. 2024 Sep 3;150(10):770-786. PMID: 38881449.
Integrative Metabolomics Differentiate Coronary Artery Disease, Peripheral Artery Disease, and Venous Thromboembolism Risks. Lee J, Gilliland TC, Dron J, Koyama S, Nakao T, Lannery K, Wong M, Peloso GM, Hornsby WE, Natarajan P. Arterioscler Thromb Vasc Biol. 2024 Sep;44(9):2108-2117. PMID: 39051123.
Genetic testing in early-onset atrial fibrillation. Kany S, Jurgens SJ, Rämö JT, Christophersen IE, Rienstra M, Chung MK, Olesen MS, Ackerman MJ, McNally EM, Semsarian C, Schnabel RB, Wilde AAM, Benjamin EJ, Rehm HL, Kirchhof P, Bezzina CR, Roden DM, Shoemaker MB, Ellinor PT. Eur Heart J. 2024 Sep 7;45(34):3111-3123. PMID: 39028637. Review.
Adenosine kinase inhibition protects mice from abdominal aortic aneurysm via epigenetic modulation of VSMC inflammation. Xu J, Liu Z, Yang Q, Ma Q, Zhou Y, Cai Y, Zhao D, Zhao G, Lu T, Ouyang K, Hong M, Kim HW, Shi H, Zhang J, Fulton D, Miller C, Malhotra R, Weintraub NL, Huo Y. Cardiovasc Res. 2024 Sep 2;120(10):1202-1217. PMID: 38722818. PMC11368124.
Obesity and age are transmission risk factors for SARS-CoV-2 infection among exposed individuals. Matamalas JT, Chelvanambi S, Decano JL, França RF, Halu A, Santinelli-Pestana DV, Aikawa E, Malhotra R, Aikawa M. PNAS Nexus. 2024 Aug 27;3(8):pgae294. PMID: 39192848. PMC11348562.
Anxiety and Depression Associated With Increased Cardiovascular Disease Risk Through Accelerated Development of Risk Factors. Civieri G, Abohashem S, Grewal SS, Aldosoky W, Qamar I, Hanlon E, Choi KW, Shin LM, Rosovsky RP, Bollepalli SC, Lau HC, Armoundas A, Seligowski AV, Turgeon SM, Pitman RK, Tona F, Wasfy JH, Smoller JW, Iliceto S, Goldstein J, Gebhard C, Osborne MT, Tawakol A. JACC Adv. 2024 Aug 14;3(9):101208.PMID: 39238850.
Percent Predicted Peak Exercise Oxygen Pulse Provides Insights Into Ventricular-Vascular Response and Prognosticates HFpEF. Li JP, Slocum C, Sbarbaro J, Schoenike M, Campain J, Prasad C, Nayor MG, Lewis GD, Malhotra R. JACC Adv. 2024 Jul 12;3(8):101101. PMID: 39105119. PMC11299572.
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes.
Kwak SH, Hernandez-Cancela RB, DiCorpo DA, Condon DE, Merino J, Wu P, Brody JA, Yao J, Guo X, Ahmadizar F, Meyer M, Sincan M, Mercader JM, Lee S, Haessler J, Vy HMT, Lin Z, Armstrong ND, Gu S, Tsao NL, Lange LA, Wang N, Wiggins KL, Trompet S, Liu S, Loos RJF, Judy R, Schroeder PH, Hasbani NR, Bos MM, Morrison AC, Jackson RD, Reiner AP, Manson JE, Chaudhary NS, Carmichael LK, Chen YI, Taylor KD, Ghanbari M, van Meurs J, Pitsillides AN, Psaty BM, Noordam R, Do R, Park KS, Jukema JW, Kavousi M, Correa A, Rich SS, Damrauer SM, Hajek C, Cho NH, Irvin MR, Pankow JS, Nadkarni GN, Sladek R, Goodarzi MO, Florez JC, Chasman DI, Heckbert SR, Kooperberg C, Dupuis J, Malhotra R, de Vries PS, Liu CT, Rotter JI, Meigs JB; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Diabetes Care. 2024 Jun 1;47(6):1042-1047. PMID: 38652672. PMC11116923.
Genetically proxied low-density lipoprotein cholesterol lowering via PCSK9-inhibitor drug targets and risk of congenital malformations. Ardissino M, Slob EAW, Reddy RK, Morley AP, Schuermans A, Hill P, Williamson C, Honigberg MC, de Marvao A, Ng FS. Eur J Prev Cardiol. 2024 Jun 3;31(8):955-965. PMID: 38294056. PMC11144467.
Cardiovascular Significance and Genetics of Epicardial and Pericardial Adiposity. Rämö JT, Kany S, Hou CR, Friedman SF, Roselli C, Nauffal V, Koyama S, Karjalainen J, Maddah M, Palotie A, Ellinor PT, Pirruccello JP; FinnGen. JAMA Cardiol. 2024 May 1;9(5):418-427.PMID: 38477908. PMC10938251.
Outcomes of peripheral artery disease and polyvascular disease in patients with end-stage kidney disease. Mehta H, Chan WC, Aday AW, Jones WS, Parmar GM, Hance K, Thors A, Alli A, Wiley M, Tadros P, Gupta K. J Vasc Surg. 2024 May;79(5):1170-1178.e10. PMID: 38244643.
Delays in Accessing Healthcare Across the Gender Spectrum in the All of Us Research Program. Finneran P, Toribio MP, Natarajan P, Honigberg MC. J Gen Intern Med. 2024 May;39(7):1156-1163. PMID: 38049655. PMC11116354.
Genetically Predicted Gestational Age and Birth Weight Are Associated With Cardiac and Pulmonary Vascular Remodeling in Adulthood. Schuermans A, Ardissino M, Nauffal V, Khurshid S, Pirruccello JP, Ellinor PT, Lewandowski AJ, Natarajan P, Honigberg MC. Eur J Prev Cardiol. 2024 May 11;31(7):e49-e52. PMID: 37694688. PMC10925550.
The Role of Genetics in Advancing Cardiometabolic Drug Development. Abou-Karam R, Cheng F, Gady S, Fahed AC. Curr Atheroscler Rep. 2024 May;26(5):153-162. PMID: 38451435. Review.
Cardiac contractility modulation in patients with heart failure – A review of the literature. Bazoukis G, Saplaouras A, Efthymiou P, Yiannikourides A, Liu T, Letsas KP, Efremidis M, Lampropoulos K, Xydonas S, Tse G, Armoundas AA. Heart Fail Rev. 2024 May;29(3):689-705. PMID: 38393423. Review.
Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis. Small AM, Melloni GEM, Kamanu FK, Bergmark BA, Bonaca MP, O’Donoghue ML, Giugliano RP, Scirica BM, Bhatt D, Antman EM, Raz I, Wiviott SD, Truong B, Wilson PWF, Cho K, O’Donnell CJ, Braunwald E, Lubitz SA, Ellinor P, Peloso GM, Ruff CT, Sabatine MS, Natarajan P, Marston NA. JAMA Cardiol. 2024 Apr 1;9(4):357-366. PMID: 38416462. PMC10902779.
Noninvasive Quantification of Radiation-Induced Lung Injury Using a Targeted Molecular Imaging Probe. Abston E, Zhou IY, Saenger JA, Shuvaev S, Akam E, Esfahani SA, Hariri LP, Rotile NJ, Crowley E, Montesi SB, Humblet V, Arabasz G, Khandekar M, Catana C, Fintelmann FJ, Caravan P, Lanuti M. Int J Radiat Oncol Biol Phys. 2024 Apr 1;118(5):1228-1239. PMID: 38072325. PMC11184492.
Keeping to the Rhythm of Cardiovascular Health. Kany S, Khurshid S. Eur J Prev Cardiol. 2024 Apr 18;31(6):655-657. PMID: 38159042. PMC11025035.
Sex Differences in the Association of Multiethnic Genome-Wide Blood Pressure Polygenic Risk Score With Population-Level Systolic Blood Pressure Trajectories. Shetty NS, Pampana A, Patel N, Yerabolu K, Patel G, Irvin MR, Natarajan P, Lin HJ, Guo X, Rich SS, Rotter JI, Li P, Arora G, Arora P. Circ Genom Precis Med. 2024 Apr;17(2):e004515. PMID: 38372177. PMC11021155.
Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation. Lin AE, Bapat AC, Xiao L, Niroula A, Ye J, Wong WJ, Agrawal M, Farady CJ, Boettcher A, Hergott CB, McConkey M, Flores-Bringas P, Shkolnik V, Bick AG, Milan D, Natarajan P, Libby P, Ellinor PT, Ebert BL. Circulation. 2024 Apr 30;149(18):1419-1434. PMID: 38357791. PMC11058018.
Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations. Small AM, Pournamdari A, Melloni GEM, Scirica BM, Bhatt DL, Raz I, Braunwald E, Giugliano RP, Sabatine MS, Peloso GM, Marston NA, Natarajan P. JAMA Cardiol. JAMA Cardiol. 2024 Apr 1;9(4):385-391. PMID: 38353970. PMC10867772.
CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis. Cheng H, Hua L, Tang H, Bao Z, Xu X, Zhu H, Wang S, Jiapaer Z, Bhatia R, Dunn IF, Deng J, Wang D, Sun S, Luan S, Ji J, Xie Q, Yang X, Lei J, Li G, Wang X, Gong Y. J Mol Cell Biol. 2024 Apr 4;15(10):mjad057. PMID: 37791390. PMC11195615.
Individual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis in the Women’s Health Initiative. Love SM, Collins JM, Anthony KM, Buchheit SF, Butler EN, Bey GS, Gondalia R, Hayden KM, Zannas AS, Bick AG, Manson JE, Desai PM, Natarajan P, Bhattacharya R, Jaiswal S, Barac A, Reiner A, Kooperberg C, Stewart JD, Whitsel EA. Womens Health Issues. 2024 Mar-Apr;34(2):197-207. PMID: 38061917. PMC10978295.
Unlocking the dark matter: noncoding RNAs and RNA modifications in cardiac aging. Kang J, Rhee J, Wang C, Yang Y, Li G, Li H. Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H832-H844. PMID: 38305752. PMC11221808 Review.
Comparative Analysis of Polymer Versus Non-Polymer Jacketed Wires in Chronic Total Occlusion Percutaneous Coronary Intervention. Alexandrou M, Rempakos A, Mutlu D, Ogaili AA, Choi JW, Poommipanit P, Alaswad K, Basir MB, Davies R, Benton S, Jaffer FA, Chandwaney RH, Kearney KE, ElGuindy AM, Rafeh NA, Goktekin O, Gorgulu S, Khatri JJ, Krestyaninov O, Khelimskii D, Rangan BV, Mastrodemos OC, Burke MN, Sandoval Y, Lombardi WL, Brilakis ES, Azzalini L. Am J Cardiol. 2024 Mar 15;215:10-18. PMID: 38224729.
Effect of Macitentan in Pulmonary Arterial Hypertension and the Relationship Between Echocardiography and cMRI Variables: REPAIR Echocardiography Sub-study Results. Torbicki A, Channick R, Galiè N, Kiely DG, Moceri P, Peacock A, Swift AJ, Tawakol A, Vonk Noordegraaf A, Flores D, Martin N, Rosenkranz S. Cardiol Ther. 2024 Mar;13(1):173-190. PMID: 38281309. PMC10899124.
MMCT-Loop: a mix model-based pipeline for calling targeted 3D chromatin loops. Tang L, Liao J, Hill MC, Hu J, Zhao Y, Ellinor PT, Li M. Nucleic Acids Res. 2024 Mar 21;52(5):e25. PMID: 38281134. PMC10954456.
Uncovering Unrecognized Heart Failure With Preserved Ejection Fraction Among Individuals With Obesity and Dyspnea. Kosyakovsky LB, Liu EE, Wang JK, Myers L, Parekh JK, Knauss H, Lewis GD, Malhotra R, Nayor M, Robbins JM, Gerszten RE, Hamburg NM, McNeill JN, Lau ES, Ho JE. Circ Heart Fail. 2024 May;17(5):e011366. PMID: 38742409. PMC11214582.
Clinical Utility of Infrapopliteal Calcium Score for the Evaluation of Severity of Peripheral Artery Disease. Lee S, Tanaka M, Patel S, Zacharias N, Hedgire S, Malhotra R, Dua A. J Vasc Interv Radiol. 2024 Mar;35(3):370-376.e2. PMID: 38043705. PMC11179150.
Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia. Schuermans A, Truong B, Ardissino M, Bhukar R, Slob EAW, Nakao T, Dron JS, Small AM, Cho SMJ, Yu Z, Hornsby W, Antoine T, Lannery K, Postupaka D, Gray KJ, Yan Q, Butterworth AS, Burgess S, Wood MJ, Scott NS, Harrington CM, Sarma AA, Lau ES, Roh JD, Januzzi JL Jr, Natarajan P, Honigberg MC. JAMA Cardiol. 2024 Mar 1;9(3):209-220. PMID: 38170504. PMC10765315.
Association of Somatic TET2 Mutations With Giant Cell Arteritis. Robinette ML, Weeks LD, Kramer RJ, Agrawal M, Gibson CJ, Yu Z, Sekar A, Mehta A, Niroula A, Brown JT, McDermott GC, Reshef ER, Lu JE, Liou VD, Chiou CA, Natarajan P, Freitag SK, Rao DA, Ebert BL. Arthritis Rheumatol. 2024 Mar;76(3):438-443. PMID: 37909388. PMC10922498.
Infertility and Subclinical Antecedents of Heart Failure With Preserved Ejection Fraction in the Framingham Heart Study. Zhou JC, Zhao Y, Bello N, Benjamin EJ, Ramachandran VS, Levy D, Cheng S, Murabito JM, Ho JE, Lau ES. J Card Fail. 2024 Mar;30(3):513-515. PMID: 37979670. PMC10947933.
A Lifestyle Modification Program for Secondary Prevention of Atrial Fibrillation: Introductory Findings. Ashburner JM, Carmichael TD, Bhattacharya R, Natarajan P, Singer DE, Thorndike AN. J Cardiopulm Rehabil Prev. 2024 Mar 1;44(2):143-145. PMID: 38113350. PMC10863832.
Complex Genetic Architecture of Spontaneous Coronary Artery Dissection. Natarajan P, Day SM. JAMA Cardiol. 2024 Mar 1;9(3):262. PMID: 38265841.
PTSD increases risk for major adverse cardiovascular events through neural and cardio-inflammatory pathways. Seligowski AV, Grewal SS, Abohashem S, Zureigat H, Qamar I, Aldosoky W, Gharios C, Hanlon E, Alani O, Bollepalli SC, Armoundas A, Fayad ZA, Shin LM, Osborne MT, Tawakol A. Brain Behav Immun. 2024 Mar;117:149-154. PMID: 38218349. PMC10932910.
Convergence of coronary artery disease genes onto endothelial cell programs. Schnitzler GR, Kang H, Fang S, Angom RS, Lee-Kim VS, Ma XR, Zhou R, Zeng T, Guo K, Taylor MS, Vellarikkal SK, Barry AE, Sias-Garcia O, Bloemendal A, Munson G, Guckelberger P, Nguyen TH, Bergman DT, Hinshaw S, Cheng N, Cleary B, Aragam K, Lander ES, Finucane HK, Mukhopadhyay D, Gupta RM, Engreitz JM. Nature. 2024 Feb;626(8000):799-807. PMID: 38326615. PMC10921916.
Lack of leisure time physical activity and variations in cardiovascular mortality across US communities: a comprehensive county-level analysis (2011-2019). Abohashem S, Nasir K, Munir M, Sayed A, Aldosoky W, Abbasi T, Michos ED, Gulati M, Rana JS. Br J Sports Med. 2024 Feb 9;58(4):204-212. PMID: 38212043.
Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a. Armani-Tourret M, Gao C, Hartana CA, Sun W, Carrere L, Vela L, Hochroth A, Bellefroid M, Sbrolla A, Shea K, Flynn T, Roseto I, Rassadkina Y, Lee C, Giguel F, Malhotra R, Bushman FD, Gandhi RT, Yu XG, Kuritzkes DR, Lichterfeld M. Cell. 2024 Feb 29;187(5):1238-1254.e14. PMID: 38367616. PMC10903630.
Risk factors for clonal hematopoiesis of indeterminate potential in people with HIV: a report from the REPRIEVE trial. Bhattacharya R, Uddin MM, Patel AP, Niroula A, Finneran P, Bernardo R, Fitch KV, Lu MT, Bloomfield GS, Malvestutto C, Aberg JA, Fichtenbaum CJ, Hornsby W, Ribaudo HJ, Libby P, Ebert BL, Zanni MV, Douglas PS, Grinspoon SK, Natarajan P. Blood Adv. 2024 Feb 27;8(4):959-967. PMID: 38197863. PMC10877123.
Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias. Schuermans A, Vlasschaert C, Nauffal V, Cho SMJ, Uddin MM, Nakao T, Niroula A, Klarqvist MDR, Weeks LD, Lin AE, Saadatagah S, Lannery K, Wong M, Hornsby W, Lubitz SA, Ballantyne C, Jaiswal S, Libby P, Ebert BL, Bick AG, Ellinor PT, Natarajan P, Honigberg MC. Eur Heart J. 2024 Mar 7;45(10):791-805. PMID: 37952204. PMC10919923.
The impact of government policies, funding, and networking to accelerate transatlantic cardiovascular research. Acharya S, Das S, Devaux Y, Robinson EL. Eur Heart J. 2024 Feb 21;45(8):567-569. PMID: 38103179.
Trends of Lipid Concentrations, Awareness, Evaluation, and Treatment in Severe Dyslipidemia in US Adults. Shetty NS, Gaonkar M, Patel N, Knowles JW, Natarajan P, Arora G, Arora P. Mayo Clin Proc. 2024 Feb;99(2):271-282. PMID: 38189687. PMC10873035.
Comparison of cardiac magnetic resonance imaging, functional and haemodynamic variables in pulmonary arterial hypertension: insights from REPAIR. Kiely DG, Channick R, Flores D, Galiè N, MacDonald G, Marcus JT, Mitchell L, Peacock A, Rosenkranz S, Tawakol A, Torbicki A, Vonk Noordegraaf A, Swift AJ. ERJ Open Res. 2024 Feb 12;10(1):00547-2023. PMID: 38348238. PMC10860210.
Using Genomics to Identify Novel Therapeutic Targets for Aortic Disease. Raghavan A, Pirruccello JP, Ellinor PT, Lindsay ME. Arterioscler Thromb Vasc Biol. 2024 Feb;44(2):334-351. PMID: 38095107. PMC10843699. Review.
Using Genomics to Identify Novel Therapeutic Targets for Aortic Disease. Raghavan A, Pirruccello JP, Ellinor PT, Lindsay ME. Arterioscler Thromb Vasc Biol. 2024 Feb;44(2):334-351. PMID: 38095107. PMC10843699. Review.
Roles of Activin A and Gpnmb in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Liu H, Yerevanian A, Westerhoff M, Hastings MH, Guerra JRB, Zhao M, Svensson KJ, Cai B, Soukas AA, Rosenzweig A. Diabetes. 2024 Feb 1;73(2):260-279. PMID: 37934943. PMC10796305.
Cumulative Diastolic Blood Pressure Burden in Normal Systolic Blood Pressure and Cardiovascular Disease. Cho SMJ, Lee H, Koyama S, Zou RS, Schuermans A, Ganesh S, Hornsby W, Honigberg MC, Natarajan P. Hypertension. 2024 Feb;81(2):273-281. PMID: 38084606. PMC10841692.
A disease of her own? Unique features of heart failure in women. Spacht WA, Lau ES. Climacteric. 2024 Feb;27(1):32-40. PMID: 37768321. PMC10843094. Review.
Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association. Ardissino M, Morley AP, Slob EAW, Schuermans A, Rayes B, Raisi-Estabragh Z, de Marvao A, Burgess S, Rogne T, Honigberg MC, Ng FS. Eur Heart J. 2024 Feb 7;45(6):443-454. PMID: 37738114. PMC10849320.
HIPK1: a New Druggable Kinase Target for Treating Pathological Cardiac Hypertrophy. Spanos M, Gokulnath P, Chatterjee E, Varrias D, Sun L, Das S, Li G. J Cardiovasc Transl Res. 2024 Feb;17(1):230-232. PMID: 37326697.
Comparison of cardiac magnetic resonance imaging, functional and haemodynamic variables in pulmonary arterial hypertension: insights from REPAIR. Kiely DG, Channick R, Flores D, Galiè N, MacDonald G, Marcus JT, Mitchell L, Peacock A, Rosenkranz S, Tawakol A, Torbicki A, Vonk Noordegraaf A, Swift AJ. ERJ Open Res. 2024 Feb 12;10(1):00547-2023. PMID: 38348238. PMC10860210.
Radon Exposure, Clonal Hematopoiesis, and Stroke Susceptibility in the Women’s Health Initiative. Anthony KM, Collins JM, Love SM, Stewart JD, Buchheit SF, Gondalia R, Schwartz GG, Huang DY, Meliker JR, Zhang Z, Barac A, Desai P, Hayden KM, Honigberg MC, Jaiswal S, Natarajan P, Bick AG, Kooperberg C, Manson JE, Reiner AP, Whitsel EA. Neurology. 2024 Jan 23;102(2):e208055. PMID: 38170948. PMC10870742.
Per-Particle Cardiovascular Risk of Lipoprotein(a) vs Non-Lp(a) Apolipoprotein B-Containing Lipoproteins. Marston NA, Melloni GEM, Murphy SA, Morze J, Kamanu FK, Ellinor PT, Ruff CT, Sabatine MS. J Am Coll Cardiol. 2024 Jan 23;83(3):470-472. PMID: 38233021.
Clonal Hematopoiesis Risk Score and All-Cause and Cardiovascular Mortality in Older Adults. Saadatagah S, Uddin MM, Weeks LD, Niroula A, Ru M, Takahashi K, Gondek L, Yu B, Bick AG, Ebert BL, Platz EA, Natarajan P, Ballantyne CM. JAMA Netw Open. 2024 Jan 2;7(1):e2351927. PMID: 38231513. PMC10794939.
Systemic Arterial Oxygen Levels Differentiate Pre- and Post-capillary Predominant Hemodynamic Abnormalities During Exercise in Undifferentiated Dyspnea on Exertion. Hardin KM, Giverts I, Campain J, Farrell R, Cunningham T, Brooks L, Christ A, Wooster L, Bailey CS, Schoenike M, Sbarbaro J, Baggish A, Nayor M, Ho JE, Malhotra R, Shah R, Lewis GD. J Card Fail. 2024 Jan;30(1):39-47. PMID: 37467924.
DeepFreeze 3D-biofabrication for Bioengineering and Storage of Stem Cells in Thick and Large-Scale Human Tissue Analogs. Kumar A, Brown RA, Roufaeil DB, Gupta A, Lipford EL, Muthusamy D, Zalzman A, Hertzano R, Lowe T, Stains JP, Zalzman M. Adv Sci (Weinh). 2024 Jan 6:e2306683. PMID: 38183347. PMC10953591.
SGLT2 Inhibitors in Patients With Cancer Therapy-Related Cardiotoxicity: An Unexpected Benefit? Oren O, Natarajan P, Bhatt DL. JACC Heart Fail. 2024 Jan;12(1):79-82. PMID: 37999662.
Characteristics and Attitudes of Wearable Device Users and Nonusers in a Large Health Care System. Venn RA, Khurshid S, Grayson M, Ashburner JM, Al-Alusi MA, Chang Y, Foulkes A, Ellinor PT, McManus DD, Singer DE, Atlas SJ, Lubitz SA. J Am Heart Assoc. 2024 Jan 2;13(1):e032126. PMID: 38156452. PMC10863832.
Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health. Zekavat SM, Jorshery SD, Rauscher FG, Horn K, Sekimitsu S, Koyama S, Nguyen TT, Costanzo MC, Jang D, Burtt NP, Kühnapfel A, Shweikh Y, Ye Y, Raghu V, Zhao H, Ghassemi M, Elze T, Segrè AV, Wiggs JL, Del Priore L, Scholz M, Wang JC, Natarajan P, Zebardast N. Sci Transl Med. 2024 Jan 24;16(731):eadg4517. PMID: 38266105.
Mendelian Randomization and Cardiovascular Disease-Enabling Expert Readership. Natarajan P, Yancy CW. JAMA Cardiol. 2024 Jan 1;9(1):89-90. PMID: 37938849.
Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas. Hughes O, Bentley AR, Breeze CE, Aguet F, Xu X, Nadkarni G, Sun Q, Lin BM, Gilliland T, Meyer MC, Du J, Raffield LM, Kramer H, Morton RW, Gouveia MH, Atkinson EG, Valladares-Salgado A, Wacher-Rodarte N, Dueker ND, Guo X, Hai Y, Adeyemo A, Best LG, Cai J, Chen G, Chong M, Doumatey A, Eales J, Goodarzi MO, Ipp E, Irvin MR, Jiang M, Jones AC, Kooperberg C, Krieger JE, Lange EM, Lanktree MB, Lash JP, Lotufo PA, Loos RJF, Ha My VT, Peralta-Romero J, Qi L, Raffel LJ, Rich SS, Rodriquez EJ, Tarazona-Santos E, Taylor KD, Umans JG, Wen J, Young BA, Yu Z, Zhang Y, Ida Chen YD, Rundek T, Rotter JI, Cruz M, Fornage M, Lima-Costa MF, Pereira AC, Paré G, Natarajan P, Cole SA, Carson AP, Lange LA, Li Y, Perez-Stable EJ, Do R, Charchar FJ, Tomaszewski M, Mychaleckyj JC, Rotimi C, Morris AP, Franceschini N. Cell Genom. 2024 Jan 10;4(1):100468. PMID: 38190104. PMC10794846.
Clonal Hematopoiesis and Cardiovascular Disease in Patients With Multiple Myeloma Undergoing Hematopoietic Cell Transplant. Rhee JW, Pillai R, He T, Bosworth A, Chen S, Atencio L, Oganesyan A, Peng K, Guzman T, Lukas K, Sigala B, Iukuridze A, Lindenfeld L, Jamal F, Natarajan P, Goldsmith S, Krishnan A, Rosenzweig M, Wong FL, Forman SJ, Armenian S. JAMA Cardiol. 2024 Jan 1;9(1):16-24. PMID: 37938837. PMC10633387.
The Science of Precision Prevention: Research Opportunities and Clinical Applications to Reduce Cardiovascular Health Disparities. Pearson TA, Vitalis D, Pratt C, Campo R, Armoundas AA, Au D, Beech B, Brazhnik O, Chute CG, Davidson KW, Diez-Roux AV, Fine LJ, Gabriel D, Groenveld P, Hall J, Hamilton AB, Hu H, Ji H, Kind A, Kraus WE, Krumholz H, Mensah GA, Merchant RM, Mozaffarian D, Murray DM, Neumark-Sztainer D, Petersen M, Goff D. JACC Adv. 2024 Jan;3(1):100759. PMID: 38375059. PMC10876066.
Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease. Zhu QM, Hsu YH, Lassen FH, MacDonald BT, Stead S, Malolepsza E, Kim A, Li T, Mizoguchi T, Schenone M, Guzman G, Tanenbaum B, Fornelos N, Carr SA, Gupta RM, Ellinor PT, Lage K. Commun Biol. 2024 Jan 12;7(1):87. PMID: 38216744. PMC10786878.
SGLT2 Inhibitors in Patients With Cancer Therapy-Related Cardiotoxicity: An Unexpected Benefit? Oren O, Natarajan P, Bhatt DL. JACC Heart Fail. 2024 Jan;12(1):79-82. PMID: 37999662.
Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease. Rogers MA, Bartoli-Leonard F, Zheng KH, Small AM, Chen HY, Clift CL, Asano T, Kuraoka S, Blaser MC, Perez KA, Natarajan P, Yeang C, Stroes ESG, Tsimikas S, Engert JC, Thanassoulis G, O’Donnell CJ, Aikawa M, Singh SA, Aikawa E. Circulation. 2024 Jan 30;149(5):391-401. PMID: 37937463. PMC10842618.
Deep learned representations of the resting 12-lead electrocardiogram to predict at peak exercise. Khurshid S, Churchill TW, Diamant N, Di Achille P, Reeder C, Singh P, Friedman SF, Wasfy MM, Alba GA, Maron BA, Systrom DM, Wertheim BM, Ellinor PT, Ho JE, Baggish AL, Batra P, Lubitz SA, Guseh JS. Eur J Prev Cardiol. 2024 Jan 25;31(2):252-262. PMID: 37798122. PMC10809171.
Potential for Bridging Treatment Gaps in Cardiovascular Health in Asia With Inclusive Clinical Trials. Patel AP. JACC Asia. 2024 Jan 23;4(2):135-137. PMID: 38371288. PMC10866730.

2023

Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification. de Vries PS, Conomos MP, Singh K, Nicholson CJ, Jain D, Hasbani NR, Jiang W, Lee S, Lino Cardenas CL, Lutz SM, Wong D, Guo X, Yao J, Young EP, Tcheandjieu C, Hilliard AT, Bis JC, Bielak LF, Brown MR, Musharoff S, Clarke SL, Terry JG, Palmer ND, Yanek LR, Xu H, Heard-Costa N, Wessel J, Selvaraj MS, Li RH, Sun X, Turner AW, Stilp AM, Khan A, Newman AB, Rasheed A, Freedman BI, Kral BG, McHugh CP, Hodonsky C, Saleheen D, Herrington DM, Jacobs DR Jr, Nickerson DA, Boerwinkle E, Wang FF, Heiss G, Jun G, Kinney GL, Sigurslid HH, Doddapaneni H, Hall IM, Bensenor IM, Broome J, Crapo JD, Wilson JG, Smith JA, Blangero J, Vargas JD, Mosquera JV, Smith JD, Viaud-Martinez KA, Ryan KA, Young KA, Taylor KD, Lange LA, Emery LS, Bittencourt MS, Budoff MJ, Montasser ME, Yu M, Mahaney MC, Mahamdeh MS, Fornage M, Franceschini N, Lotufo PA, Natarajan P, Wong Q, Mathias RA, Gibbs RA, Do R, Mehran R, Tracy RP, Kim RW, Nelson SC, Damrauer SM, Kardia SLR, Rich SS, Fuster V, Napolioni V, Zhao W, Tian W, Yin X, Min YI, Manning AK, Peloso G, Kelly TN, O’Donnell CJ, Morrison AC, Curran JE, Zapol WM, Bowden DW, Becker LC, Correa A, Mitchell BD, Psaty BM, Carr JJ, Pereira AC, Assimes TL, Stitziel NO, Hokanson JE, Laurie CA, Rotter JI, Vasan RS, Post WS, Peyser PA, Miller CL, Malhotra R. Nat Cardiovasc Res. 2023 Dec;2(12):1159-1172. PMID: 38817323. PMC11138106.
Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research. Costanzo MC, Roselli C, Brandes M, Duby M, Hoang Q, Jang D, Koesterer R, Kudtarkar P, Moriondo A, Nguyen T, Ruebenacker O, Smadbeck P, Sun Y, Butterworth AS, Aragam KG, Lumbers RT, Khera AV, Lubitz SA, Ellinor PT, Gaulton KJ, Flannick J, Burtt NP. Circ Genom Precis Med. 2023 Dec;16(6):e004181. PMID: 37814896. PMC10843166.
Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways. Spanos M, Gokulnath P, Chatterjee E, Li G, Varrias D, Das S. Extracell Vesicle. 2023 Dec;2:100025. PMID: 38188000. PMC10768935.
Concordance of a High Lipoprotein(a) Concentration Among Relatives. Reeskamp LF, Tromp TR, Patel AP, Ibrahim S, Trinder M, Haidermota S, Hovingh GK, Stroes ESG, Natarajan P, Khera AV. JAMA Cardiol. 2023 Dec 1;8(12):1111-1118. PMID: 37819667. PMC10568442.
Machine Learning in Invasive and Noninvasive Coronary Angiography. Unlu O, Fahed AC. Curr Atheroscler Rep. 2023 Dec;25(12):1025-1033. PMID: 38095805. Review.
Clinical applications of polygenic risk score for coronary artery disease through the life course. Fahed AC, Natarajan P. Atherosclerosis. 2023 Dec;386:117356. PMID: 37931336. PMC10842813. Review.
Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Schoenmakers E, Marelli F, Jørgensen HF, Visser WE, Moran C, Groeneweg S, Avalos C, Jurgens SJ, Figg N, Finigan A, Wali N, Agostini M, Wardle-Jones H, Lyons G, Rusk R, Gopalan D, Twiss P, Visser JJ, Goddard M, Nashef SAM, Heijmen R, Clift P, Sinha S, Pirruccello JP, Ellinor PT, Busch-Nentwich EM, Ramirez-Solis R, Murphy MP, Persani L, Bennett M, Chatterjee K. Nat Commun. 2023 Dec 2;14(1):7994. PMID: 38042913. PMC10693596.
Skull bone marrow channels as immune gateways to the central nervous system. Mazzitelli JA, Pulous FE, Smyth LCD, Kaya Z, Rustenhoven J, Moskowitz MA, Kipnis J, Nahrendorf M. Nat Neurosci. 2023 Dec;26(12):2052-2062. PMID: 37996526. PMC10894464. Review.
Accuracy and variability of cardiologist interpretation of single lead electrocardiograms for atrial fibrillation: The VITAL-AF trial. Pipilas DC, Khurshid S, Atlas SJ, Ashburner JM, Lipsanopoulos AT, Borowsky LH, Guan W, Ellinor PT, McManus DD, Singer DE, Chang Y, Lubitz SA. Am Heart J. 2023 Nov;265:92-103. PMID: 37451355. PMC11194686.
Transcriptional profile of the rat cardiovascular system at single cell resolution. Arduini A, Fleming SJ, Xiao L, Hall AW, Akkad AD, Chaffin M, Bendinelli KJ, Tucker NR, Papangeli I, Mantineo H, Babadi M, Stegmann CM, García-Cardeña G, Lindsay ME, Klattenhoff C, Ellinor PT. bioRxiv [Preprint]. 2023 Nov 16:2023.11.14.567085. PMID: 38014050. PMC10680727.
Massive underrepresentation of Arabs in genomic studies of common disease. Bhattacharya R, Chen N, Shim I, Kuwahara H, Gao X, Alkuraya FS, Fahed AC. Genome Med. 2023 Nov 22;15(1):99. PMID: 37993966. PMC10664351.
MSGene: Derivation and validation of a multistate model for lifetime risk of coronary artery disease using genetic risk and the electronic health record. Urbut SM, Yeung MW, Khurshid S, Cho SMJ, Schuermans A, German J, Taraszka K, Fahed AC, Ellinor P, Trinquart L, Parmigiani G, Gusev A, Natarajan P. medRxiv [Preprint]. 2023 Nov 8:2023.11.08.23298229. PMID: 37986972. PMC10659503.
Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction. Lau ES, Roshandelpoor A, Zarbafian S, Wang D, Guseh JS, Allen N, Varadarajan V, Nayor M, Shah RV, Lima JAC, Shah SJ, Yu B, Alotaibi M, Cheng S, Jain M, Lewis GD, Ho JE. Nat Commun. 2023 Nov 20;14(1):7557. PMID: 37985769. PMC10662264.
A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies. Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly T, Konigsberg I, Kooperberg C, Kral BG, Li C, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Palmer ND, Peyser PA, Psaty BM, Raffield LM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari H, Vasan RS, Wang Z, Yanek LR, Yu B; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X. bioRxiv [Preprint]. 2023 Nov 2:2023.10.30.564764. PMID: 37961350. PMC10634938.
Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis. Mosquera JV, Auguste G, Wong D, Turner AW, Hodonsky CJ, Alvarez-Yela AC, Song Y, Cheng Q, Lino Cardenas CL, Theofilatos K, Bos M, Kavousi M, Peyser PA, Mayr M, Kovacic JC, Björkegren JLM, Malhotra R, Stukenberg PT, Finn AV, van der Laan SW, Zang C, Sheffield NC, Miller CL. Cell Rep. 2023 Nov 28;42(11):113380. PMID: 37950869. PMC12335892.
Deep Learning-Enabled Assessment of Left Heart Structure and Function Predicts Cardiovascular Outcomes. Lau ES, Di Achille P, Kopparapu K, Andrews CT, Singh P, Reeder C, Al-Alusi M, Khurshid S, Haimovich JS, Ellinor PT, Picard MH, Batra P, Lubitz SA, Ho JE. J Am Coll Cardiol. 2023 Nov 14;82(20):1936-1948. PMID: 37940231. PMC10696641.
Clinical perspectives on the adoption of the artificial intelligence-enabled electrocardiogram. Khurshid S. J Electrocardiol. 2023 Nov-Dec;81:142-145. PMID: 37696174. PMC11185998. Review.
Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in the CETP Gene. Yu C, Bakshi A, Watts GF, Renton AE, Fulton-Howard B, Goate AM, Natarajan P, Chasman DI, Robman L, Woods RL, Guymer R, Wolfe R, Thao LTP, McNeil JJ, Tonkin AM, Nicholls SJ, Lacaze P. J Am Heart Assoc. 2023 Nov 7;12(21):e031459. PMID: 37929782. PMC10727421.
Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling. Kim E, Kim H, Jedrychowski MP, Bakiasi G, Park J, Kruskop J, Choi Y, Kwak SS, Quinti L, Kim DY, Wrann CD, Spiegelman BM, Tanzi RE, Choi SH. Neuron. 2023 Nov 15;111(22):3619-3633.e8. PMID: 37689059. PMC10840702.
The GenoVA study: Equitable implementation of a pragmatic randomized trial of polygenic-risk scoring in primary care. Vassy JL, Brunette CA, Lebo MS, MacIsaac K, Yi T, Danowski ME, Alexander NVJ, Cardellino MP, Christensen KD, Gala M, Green RC, Harris E, Jones NE, Kerman BJ, Kraft P, Kulkarni P, Lewis ACF, Lubitz SA, Natarajan P, Antwi AA. Am J Hum Genet. 2023 Nov 2;110(11):1841-1852. PMID: 37922883. PMC10645559. Clinical Trial.
Pragmatic Approach to Applying Polygenic Risk Scores to Diverse Populations. Patel AP, Fahed AC. Curr Protoc. 2023 Nov;3(11):e911. PMID: 37921506. PMC11196001.
Circulating extracellular vesicles in human cardiorenal syndrome promote renal injury in a kidney-on-chip system. Chatterjee E, Rodosthenous RS, Kujala V, Gokulnath P, Spanos M, Lehmann HI, de Oliveira GP, Shi M, Miller-Fleming TW, Li G, Ghiran IC, Karalis K, Lindenfeld J, Mosley JD, Lau ES, Ho JE, Sheng Q, Shah R, Das S. JCI Insight. 2023 Nov 22;8(22):e165172. PMID: 37707956. PMC10721327.
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. Chen CW, Zhang L, Dutta R, Niroula A, Miller PG, Gibson CJ, Bick AG, Reyes JM, Lee YT, Tovy A, Gu T, Waldvogel S, Chen YH, Venters BJ, Estève PO, Pradhan S, Keogh MC, Natarajan P, Takahashi K, Sperling AS, Goodell MA. Cell Stem Cell. 2023 Nov 2;30(11):1503-1519.e8. PMID: 37863054. PMC10841682.
Outcomes of Chronic Total Occlusion Percutaneous Coronary Interventions in Patients With Previous Coronary Artery Bypass Graft Surgery. Alexandrou M, Kostantinis S, Rempakos A, Simsek B, Karacsonyi J, Choi JW, Poommipanit P, Alaswad K, Basir MB, Megaly M, Davies R, Benton S, Jaffer FA, Karmpaliotis D, Azzalini L, Kearney KE, ElGuindy AM, Rafeh NA, Goktekin O, Gorgulu S, Khatri JJ, Aygul N, Jaber W, Nicholson W, Rinfret S, Krestyaninov O, Khelimskii D, Rangan BV, Mastrodemos OC, Allana SS, Sandoval Y, Burke MN, Brilakis ES. Am J Cardiol. 2023 Oct 15;205:40-49. PMID: 37586120.
Genetic and clinical factors underlying a self-reported family history of heart disease. Jowell AR, Bhattacharya R, Marnell C, Wong M, Haidermota S, Trinder M, Fahed AC, Peloso GM, Honigberg MC, Natarajan P. Eur J Prev Cardiol. 2023 Oct 26;30(15):1571-1579. PMID: 37011137. PMC10545808.
The association of eicosanoids and eicosanoid-related metabolites with pulmonary hypertension. McNeill JN, Roshandelpoor A, Alotaibi M, Choudhary A, Jain M, Cheng S, Zarbafian S, Lau ES, Lewis GD, Ho JE. Eur Respir J. 2023 Oct 19;62(4):2300561. PMID: 37857430.
Decoding Genetics, Ancestry, and Geospatial Context for Precision Health. Koyama S, Wang Y, Paruchuri K, Uddin MM, Cho SMJ, Urbut SM, Haidermota S, Hornsby WE, Green RC, Daly MJ, Neale BM, Ellinor PT, Smoller JW, Lebo MS, Karlson EW, Martin AR, Natarajan P. medRxiv [Preprint]. 2023 Oct 25:2023.10.24.23297096. PMID: 37961173. PMC10635180.
Clinical utility of polygenic scores for cardiometabolic disease in Arabs. Shim I, Kuwahara H, Chen N, Hashem MO, AlAbdi L, Abouelhoda M, Won HH, Natarajan P, Ellinor PT, Khera AV, Gao X, Alkuraya FS, Fahed AC. Nat Commun. 2023 Oct 18;14(1):6535. PMID: 37852978.
Treatment of calcific arterial disease via enhancement of autophagy using GSK343. Lino Cardenas CL, Jiang W, Kajuluri LP, Singh K, Ostrom K, Li R, Cherbonneau F, Boerboom S, Birchenough C, Roh K, Chou EL, Shahrooz Z, Nicholson C, Johnson AL, Lee S, Ichinose F, Bloch DB, Nigwekar S, Ellinor PT, Musolino P, Lindsay ME, Dou Z, Miller CL, Malhotra R. iScience. 2023 Oct 29;26(11):108360. PMID: 38033629.
Metabolic Dysfunction in Aortic Stenosis: A Key Piece of the Pathophysiological Puzzle. Sosnovik DE, Elmariah S. Circ Cardiovasc Imaging. 2023 Oct;16(10):e015977. PMID: 37847765
Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study. Wang Y, Selvaraj MS, Li X, Li Z, Holdcraft JA, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Cade BE, Carlson JC, Carson AP, Chen YI, Curran JE, de Vries PS, Dutcher SK, Ellinor PT, Floyd JS, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, Guo X, He J, Heard-Costa N, Hildalgo B, Hou L, Irvin MR, Joehanes R, Kaplan RC, Kardia SL, Kelly TN, Kim R, Kooperberg C, Kral BG, Levy D, Li C, Liu C, Lloyd-Jone D, Loos RJ, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Murabito JM, Naseri T, O’Connell JR, Palmer ND, Preuss MH, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Ruepena MS, Sheu WH, Smith JA, Smith A, Tiwari HK, Tsai MY, Viaud-Martinez KA, Wang Z, Yanek LR, Zhao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Rotter JI, Lin X, Natarajan P, Peloso GM. Am J Hum Genet. 2023 Oct 5;110(10):1704-1717. PMID: 37802043.
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification. Kavousi M, Bos MM, Barnes HJ, Lino Cardenas CL, Wong D, Lu H, Hodonsky CJ, Landsmeer LPL, Turner AW, Kho M, Hasbani NR, de Vries PS, Bowden DW, Chopade S, Deelen J, Benavente ED, Guo X, Hofer E, Hwang SJ, Lutz SM, Lyytikäinen LP, Slenders L, Smith AV, Stanislawski MA, van Setten J, Wong Q, Yanek LR, Becker DM, Beekman M, Budoff MJ, Feitosa MF, Finan C, Hilliard AT, Kardia SLR, Kovacic JC, Kral BG, Langefeld CD, Launer LJ, Malik S, Hoesein FAAM, Mokry M, Schmidt R, Smith JA, Taylor KD, Terry JG, van der Grond J, van Meurs J, Vliegenthart R, Xu J, Young KA, Zilhão NR, Zweiker R, Assimes TL, Becker LC, Bos D, Carr JJ, Cupples LA, de Kleijn DPV, de Winther M, den Ruijter HM, Fornage M, Freedman BI, Gudnason V, Hingorani AD, Hokanson JE, Ikram MA, Išgum I, Jacobs DR Jr, Kähönen M, Lange LA, Lehtimäki T, Pasterkamp G, Raitakari OT, Schmidt H, Slagboom PE, Uitterlinden AG, Vernooij MW, Bis JC, Franceschini N, Psaty BM, Post WS, Rotter JI, Björkegren JLM, O’Donnell CJ, Bielak LF, Peyser PA, Malhotra R, van der Laan SW, Miller CL. Nat Genet. 2023 Oct;55(10):1651-1664. PMID: 37770635.
Prediction of experimental cardiac magnetostimulation thresholds using pig-specific body models. Klein V, Davids M, Vendramini L, Ferris NG, Schad LR, Sosnovik DE, Nguyen CT, Wald LL, Guérin B. Magn Reson Med. 2023 Oct;90(4):1594-1609. PMID: 37288580.
Vagus Nerve Stimulation and Inflammation in Cardiovascular Disease: A State-of-the-Art Review. Bazoukis G, Stavrakis S, Armoundas AA. J Am Heart Assoc. 2023 Oct 3;12(19):e030539. PMID: 37721168. Review.
Zebrafish as a high throughput model for organ preservation and transplantation research. Da Silveira Cavalcante L, Lopera Higuita M, González-Rosa JM, Marques B, To S, Pendexter CA, Cronin SEJ, Gopinathan K, de Vries RJ, Ellett F, Uygun K, Langenau DM, Toner M, Tessier SN. FASEB J. 2023 Oct;37(10):e23187. PMID: 37718489.
Angiogenesis Redux: An Overall Protective Role of VEGF/KDR Signaling in the Microvasculature in Pulmonary Arterial Hypertension. Zhong Y, Yu PB. Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):1784-1787. PMID: 37675636.
Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis. Deflaux N, Selvaraj MS, Condon HR, Mayo K, Haidermota S, Basford MA, Lunt C, Philippakis AA, Roden DM, Denny JC, Musick A, Collins R, Allen N, Effingham M, Glazer D, Natarajan P, Bick AG. Nat Commun. 2023 Sep 5;14(1):5419. PMID: 37669985.
Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender. Fleming SJ, Chaffin MD, Arduini A, Akkad AD, Banks E, Marioni JC, Philippakis AA, Ellinor PT, Babadi M. Nat Methods. 2023 Sep;20(9):1323-1335. PMID: 37550580.
Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk. Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P. J Clin Invest. 2023 Sep 15;133(18):e168597. PMID: 37498674.
Representation of Race and Ethnicity in the Contemporary US Health Cohort All of Us Research Program. Kathiresan N, Cho SMJ, Bhattacharya R, Truong B, Hornsby W, Natarajan P. JAMA Cardiol. 2023 Sep 1;8(9):859-864. PMID: 37585212.
Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis. Kim MS, Song M, Kim B, Shim I, Kim DS, Natarajan P, Do R, Won HH. Cell Rep Med. 2023 Sep 19;4(9):101112. PMID: 37582372.
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma. Benson MD, Eisman AS, Tahir UA, Katz DH, Deng S, Ngo D, Robbins JM, Hofmann A, Shi X, Zheng S, Keyes M, Yu Z, Gao Y, Farrell L, Shen D, Chen ZZ, Cruz DE, Sims M, Correa A, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Guo X, Yao J, Chen YI, Manichaikul AW, Jain D, Yang Q; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Bouchard C, Sarzynski MA, Rich SS, Rotter JI, Wang TJ, Wilson JG, Clish CB, Sarkar IN, Natarajan P, Gerszten RE. Cell Metab. 2023 Sep 5;35(9):1646-1660.e3. PMID: 37582364.
Cardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury. Rhee J, Freeman R, Roh K, Lyons M, Xiao C, Zlotoff D, Yeri A, Li H, Guerra J, Guseh JS, Kuznetsov A, Houstis N, Roh J, Damilano F, Liu X, Silverman M, Kwong R, Das S, Rosenzweig A. Circ Res. 2023 Sep 15;133(7):651-653. PMID: 37638415.
Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study. Cho SMJ, Koyama S, Honigberg MC, Surakka I, Haidermota S, Ganesh S, Patel AP, Bhattacharya R, Lee H, Kim HC, Natarajan P. Eur Heart J. 2023 Sep 21;44(36):3456-3465. PMID: 37350734.
Quantifying the causal impact of biological risk factors on healthcare costs. Lee J, Jukarainen S, Karvanen A, Dixon P, Davies NM, Smith GD, Natarajan P, Ganna A. Nat Commun. 2023 Sep 13;14(1):5672. PMID: 37704630.
Bayesian multivariate genetic analysis improves translational insights. Urbut SM, Koyama S, Hornsby W, Bhukar R, Kheterpal S, Truong B, Selvaraj MS, Neale B, O’Donnell CJ, Peloso GM, Natarajan P. iScience. 2023 Sep 9;26(10):107854. PMID: 37766997.
Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis. Uddin MM, Saadatagah S, Niroula A, Yu B, Hornsby W, Ganesh S, Lannery K, Shuermans A, Honigberg MC, Bick AG, Libby P, Ebert BL, Ballantyne CM, Natarajan P. medRxiv [Preprint]. 2023 Sep 7:2023.09.05.23295093. PMID: 37732181.
Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review. Figtree GA, Vernon ST, Harmer JA, Gray MP, Arnott C, Bachour E, Barsha G, Brieger D, Brown A, Celermajer DS, Channon KM, Chew NWS, Chong JJH, Chow CK, Cistulli PA, Ellinor PT, Grieve SM, Guzik TJ, Hagström E, Jenkins A, Jennings G, Keech AC, Kott KA, Kritharides L, Mamas MA, Mehran R, Meikle PJ, Natarajan P, Negishi K, O’Sullivan J, Patel S, Psaltis PJ, Redfern J, Steg PG, Sullivan DR, Sundström J, Vogel B, Wilson A, Wong D, Bhatt DL, Kovacic JC, Nicholls SJ; CRE for CAD Collaborators. J Am Coll Cardiol. 2023 Sep 26;82(13):1343-1359. PMID: 37730292. Review.
Comparison of the 11-Day Adhesive ECG Patch Monitor and 24-h Holter Tests to Assess the Response to Antiarrhythmic Drug Therapy in Paroxysmal Atrial Fibrillation. Kim S, Choi Y, Lee K, Kim SH, Kim H, Shin S, Park S, Oh YS. Diagnostics (Basel). 2023 Sep 28;13(19):3078. PMID: 37835822.
Noninvasive Quantification of Radiation-Induced Lung Injury using a Targeted Molecular Imaging Probe. Abston E, Zhou IY, Saenger JA, Shuvaev S, Akam E, Esfahani SA, Hariri LP, Rotile NJ, Crowley E, Montesi SB, Humblet V, Arabasz G, Catana C, Fintelmann FJ, Caravan P, Lanuti M. medRxiv [Preprint]. 2023 Sep 26:2023.09.25.23295897. PMID: 37808864.
The Fall of Roe: the Devastating Impact of the Dobbs vs Jackson Decision on Women Living With Heart Failure. Rosenblum HR, Haythe JH, Lau ES. J Card Fail. 2023 Aug;29(8):1207-1209. PMID: 37562897.
Protein Biomarkers of Early Menopause and Incident Cardiovascular Disease. Ramirez MF, Honigberg M, Wang D, Parekh JK, Bielawski K, Courchesne P, Larson MD, Levy D, Murabito JM, Ho JE, Lau ES. J Am Heart Assoc. 2023 Aug 15;12(16):e028849. PMID: 37548169.
Genetic insights into resting heart rate and its role in cardiovascular disease. van de Vegte YJ, Eppinga RN, van der Ende MY, Hagemeijer YP, Mahendran Y, Salfati E, Smith AV, Tan VY, Arking DE, Ntalla I, Appel EV, et al. Nat Commun. 2023 Aug 2;14(1):4646. PMID: 37532724.
Publisher Correction: LungElast-an open-source, flexible, low-cost, microprocessor-controlled mouse lung elastometer. Roberts JD Jr. Sci Rep. 2023 Aug 1;13(1):12460. PMID: 37528185.
Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women. Schuermans A, Nakao T, Uddin MM, Hornsby W, Ganesh S, Shadyab AH, Liu S, Haring B, Shufelt CL, Taub MA, Mathias RA, Kooperberg C, Reiner AP, Bick AG, Manson JE, Natarajan P, Honigberg MC. Circ Res. 2023 Aug 18;133(5):376-386. PMID: 37489536.
Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion. Martí-Pàmies Í, Thoonen R, Morley M, Graves L, Tamez J, Caplan A, McDaid K, Yao V, Hindle A, Gerszten RE, Farrell LA, Li L, Tseng YH, Profeta G, Buys ES, Bloch DB, Scherrer-Crosbie M. Circ Res. 2023 Aug 4;133(4):353-365. PMID: 37462036.
Identifying high risk clinical phenogroups of pulmonary hypertension through a clustering analysis. Rambarat P, Zern EK, Wang D, Roshandelpoor A, Zarbafian S, Liu EE, Wang JK, McNeill JN, Andrews CT, Pomerantsev EV, Diamant N, Batra P, Lubitz SA, Picard MH, Ho JE. PLoS One. 2023 Aug 25;18(8):e0290553. PMID: 37624825.
Loss of the Atrial Fibrillation-Related Gene, Zfhx3, Results in Atrial Dilation and Arrhythmias. Jameson HS, Hanley A, Hill MC, Xiao L, Ye J, Bapat A, Ronzier E, Hall AW, Hucker WJ, Clauss S, Barazza M, Silber E, Mina JA, Tucker NR, Mills RW, Dong JT, Milan DJ, Ellinor PT. Circ Res. 2023 Aug 4;133(4):313-329. PMID: 37449401.
Characteristics and Attitudes of Wearable Device Users and Non-Users in a Large Healthcare System. Venn RA, Khurshid S, Grayson M, Ashburner JM, Al-Alusi MA, Chang Y, Foulkes A, Ellinor PT, McManus DD, Singer DE, Atlas SJ, Lubitz SA. medRxiv [Preprint]. 2023 Aug 12:2023.08.10.23293960. PMID: 37609134.
An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses. Kim JY, Song M, Kim MS, Natarajan P, Do R, Myung W, Won HH. BMC Med. 2023 Aug 21;21(1):316. PMID: 37605270.
AORTA Gene: Polygenic prediction improves detection of thoracic aortic aneurysm. Pirruccello JP, Khurshid S, Lin H, Lu-Chen W, Zamirpour S, Kany S, Raghavan A, Koyama S, Vasan RS, Benjamin EJ, Lindsay ME, Ellinor PT. medRxiv [Preprint]. 2023 Aug 25:2023.08.23.23294513. PMID: 37662232.
Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions. Zhang W, Petri K, Ma J, Lee H, Tsai CL, Joung JK, Yeh JJ. bioRxiv [Preprint]. 2023 Aug 15:2023.08.14.553324. PMID: 37645936.
Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries. Bai Y, Li G, Yung L, Yu PB, Ai X. Am J Physiol Lung Cell Mol Physiol. 2023 Aug 1;325(2):L114-L124. PMID: 37278410.
Genetic Susceptibility to Atrial Fibrillation Identified via Deep Learning of 12-Lead Electrocardiograms. Wang X, Khurshid S, Choi SH, Friedman S, Weng LC, Reeder C, Pirruccello JP, Singh P, Lau ES, Venn R, Diamant N, Di Achille P, Philippakis A, Anderson CD, Ho JE, Ellinor PT, Batra P, Lubitz SA. Circ Genom Precis Med. 2023 Aug;16(4):340-349. PMID: 37278238.
Ketone ester supplementation suppresses cardiac inflammation and improves cardiac energetics in a swine model of acute myocardial infarction. Yurista SR, Eder RA, Welsh A, Jiang W, Chen S, Foster AN, Mauskapf A, Tang WHW, Hucker WJ, Coll-Font J, Rosenzweig A, Nguyen CT. Metabolism. 2023 Aug;145:155608. PMID: 37268056.
Association of genetic risk and outcomes in patients with atrial fibrillation: interactions with early rhythm control in the EAST-AFNET4 trial. Kany S, Al-Taie C, Roselli C, Pirruccello JP, Borof K, Reinbold C, Suling A, Krause L, Reissmann B, Schnabel RB, Zeller T, Zapf A, Wegscheider K, Fabritz L, Ellinor PT, Kirchhof P. Cardiovasc Res. 2023 Aug 7;119(9):1799-1810. PMID: 37264683. Clinical Trial.
Identification of the Key Immune Cells and Genes for the Diagnostics and Therapeutics of Meningioma. Chen J, Hua L, Xu X, Jiapaer Z, Deng J, Wang D, Zhang L, Li G, Gong Y. World Neurosurg. 2023 Aug;176:e501-e514. PMID: 37263494.
Genetic Burden of TNNI3K in Diagnostic Testing of Patients With Dilated Cardiomyopathy and Supraventricular Arrhythmias. Pham C, Andrzejczyk K, Jurgens SJ, Lekanne Deprez R, Palm KCA, Vermeer AMC, Nijman J, Christiaans I, Barge-Schaapveld DQCM, van Dessel PFHM, Beekman L, Choi SH, Lubitz SA, Skoric-Milosavljevic D, van den Bersselaar L, Jansen PR, Copier JS, Ellinor PT, Wilde AAM, Bezzina CR, Lodder EM. Circ Genom Precis Med. 2023 Aug;16(4):328-336. PMID: 37199186.
Common and rare variants associated with cardiometabolic traits across 98,622 whole-genome sequences in the All of Us research program. Wang X, Ryu J, Kim J, Ramirez A, Mayo KR; All of Us Research Program; Condon H, Vaitinadin NS, Ohno-Machado L, Talavera GA, Ellinor PT, Lubitz SA, Choi SH. J Hum Genet. 2023 Aug;68(8):565-570. PMID: 37072623.
Autonomic Nervous System and Cardiac Metabolism: Links Between Autonomic and Metabolic Remodeling in Atrial Fibrillation. Chakraborty P, Farhat K, Po SS, Armoundas AA, Stavrakis S. JACC Clin Electrophysiol. 2023 Jul;9(7 Pt 2):1196-1206. PMID: 37086229. Review.
Novel AI-based HRV analysis (NAIHA) in healthcare automation and related applications. Rahul LR, Sarkar R, Sengupta A, Chandra BS, Jana S. J Electrocardiol. 2023 Jul-Aug;79:112-121. PMID: 37031632.
The common pathobiology between coronary artery disease and calcific aortic stenosis: Evidence and clinical implications. Abdul-Rahman T, Lizano-Jubert I, Garg N, Talukder S, Lopez PP, Awuah WA, Shah R, Chambergo D, Cantu-Herrera E, Farooqi M, Pyrpyris N, de Andrade H, Mares AC, Gupta R, Aldosoky W, Mir T, Lavie CJ, Abohashem S. Prog Cardiovasc Dis. 2023 Jul-Aug;79:89-99. PMID: 37302652. Review.
Accelerometer-Derived “Weekend Warrior” Physical Activity and Incident Cardiovascular Disease. Khurshid S, Al-Alusi MA, Churchill TW, Guseh JS, Ellinor PT. JAMA. 2023 Jul 18;330(3):247-252. PMID: 37462704.
Venous Thromboembolism in Pregnancy: Challenges and Solutions. Varrias D, Spanos M, Kokkinidis DG, Zoumpourlis P, Kalaitzopoulos DR. Vasc Health Risk Manag. 2023 Jul 20;19:469-484. PMID: 37492280. Review.
The Cardiovascular Impact and Genetics of Pericardial Adiposity. Rämö JT, Kany S, Hou CR, Friedman SF, Roselli C, Nauffal V, Koyama S, Karjalainen J; FinnGen; Maddah M, Palotie A, Ellinor PT, Pirruccello JP. medRxiv [Preprint]. 2023 Jul 18:2023.07.16.23292729. PMID: 37502935.
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus. Kwak SH, Hernandez-Cancela RB, DiCorpo DA, Condon DE, Merino J, Wu P, Brody JA, Yao J, Guo X, Ahmadizar F, Meyer M, Sincan M, Mercader JM, Lee S, Haessler J, Vy HMT, Lin Z, Armstrong ND, Gu S, Tsao NL, Lange LA, Wang N, Wiggins KL, Trompet S, Liu S, Loos RJF, Judy R, Schroeder PH, Hasbani NR, Bos MM, Morrison AC, Jackson RD, Reiner AP, Manson JE, Chaudhary NS, Carmichael LK, Chen YI, Taylor KD, Ghanbari M, van Meurs J, Pitsillides AN, Psaty BM, Noordam R, Do R, Park KS, Jukema JW, Kavousi M, Correa A, Rich SS, Damrauer SM, Hajek C, Cho NH, Irvin MR, Pankow JS, Nadkarni GN, Sladek R, Goodarzi MO, Florez JC, Chasman DI, Heckbert SR, Kooperberg C, Dupuis J, Malhotra R, de Vries PS, Liu CT, Rotter JI, Meigs JB. medRxiv [Preprint]. 2023 Jul 28:2023.07.25.23293180. PMID: 37546893.
Clinical and Genetic Atrial Fibrillation Risk and Discrimination of Cardioembolic From Noncardioembolic Stroke. Weng LC, Khurshid S, Gunn S, Trinquart L, Lunetta KL, Xu H; NINDS Stroke Genetics Network*; Benjamin EJ, Ellinor PT, Anderson CD, Lubitz SA. Stroke. 2023 Jul;54(7):1777-1785. PMID: 37363945.
Recruited macrophages elicit atrial fibrillation. Hulsmans M, Schloss MJ, Lee IH, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous FE, Keller D, Bening C, Green U, Lennerz JK, Mitchell RN, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong CS, Pierson RN, Aster JC, Rohde D, Wojtkiewicz GR, Weissleder R, Swirski FK, Tellides G, Tolis G Jr, Melnitchouk S, Milan DJ, Ellinor PT, Naxerova K, Nahrendorf M. Science. 2023 Jul 14;381(6654):231-239. PMID: 37440641.
LungElast-an open-source, flexible, low-cost, microprocessor-controlled mouse lung elastometer. Roberts JD Jr. Sci Rep. 2023 Jul 12;13(1):11246. PMID: 37438462.
A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease. Patel AP, Wang M, Ruan Y, Koyama S, Clarke SL, Yang X, Tcheandjieu C, Agrawal S, Fahed AC, Ellinor PT; Genes & Health Research Team; the Million Veteran Program; Tsao PS, Sun YV, Cho K, Wilson PWF, Assimes TL, van Heel DA, Butterworth AS, Aragam KG, Natarajan P, Khera AV. Nat Med. 2023 Jul;29(7):1793-1803. PMID: 37414900.
Effect of clinic-based single-lead electrocardiogram rhythm assessment on oral anticoagulation prescriptions in patients with previously diagnosed atrial fibrillation. Ashburner JM, Chang Y, Borowsky LH, Khurshid S, McManus DD, Ellinor PT, Lubitz SA, Singer DE, Atlas SJ. Heart Rhythm O2. 2023 Jul 12;4(8):469-477. PMID: 37645259.
Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia. Plotnikov MB, Chernysheva GA, Smol’yakova VI, Aliev OI, Anishchenko AM, Ulyakhina OA, Trofimova ES, Ligacheva AA, Anfinogenova ND, Osipenko AN, Kovrizhina AR, Khlebnikov AI, Schepetkin IA, Drozd AG, Plotnikov EV, Atochin DN, Quinn MT. Pharmaceuticals (Basel). 2023 Jul 25;16(8):1057. PMID: 37630972.
Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease. Limpitikul WB, Das S. J Cardiovasc Dev Dis. 2023 Jul 30;10(8):323. PMID: 37623336. Review.
Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood. Schuermans A, Nakao T, Ruan Y, Koyama S, Yu Z, Uddin MM, Haidermota S, Hornsby W, Lewandowski AJ, Bick AG, Niroula A, Jaiswal S, Ebert BL, Natarajan P, Honigberg MC. J Am Heart Assoc. 2023 Jul 4;12(13):e030220. PMID: 37345823.
H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia. Deng J, Zhao HJ, Zhong Y, Hu C, Meng J, Wang C, Lan X, Wang X, Chen ZJ, Yan J, Wang W, Li Y. EBioMedicine. 2023 Jul;93:104664. PMID: 37331163.
Clonal hematopoiesis is associated with protection from Alzheimer’s disease. Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT Jr, Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S. Nat Med. 2023 Jul;29(7):1662-1670. PMID: 37322115.
Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program. Klarin D, Devineni P, Sendamarai AK, Angueira AR, Graham SE, Shen YH, Levin MG, Pirruccello JP, Surakka I, Karnam PR, Roychowdhury T, Li Y, Wang M, Aragam KG, Paruchuri K, Zuber V, Shakt GE, Tsao NL, Judy RL, Vy HMT, Verma SS, Rader DJ, Do R, Bavaria JE, Nadkarni GN, Ritchie MD; VA Million Veteran Program; Burgess S, Guo DC, Ellinor PT, LeMaire SA, Milewicz DM, Willer CJ, Natarajan P, Tsao PS, Pyarajan S, Damrauer SM. Nat Genet. 2023 Jul;55(7):1106-1115. PMID: 37308786.
Wall shear rate and energy loss coefficient measures using conventional Doppler ultrasound do not predict carotid plaque progression. Goudot G, Bellomo TR, Gaston B, Pauly M, Patel S, Manchester S, Dua A. Vasa. 2023 Jul;52(4):249-256. PMID: 37128732.
Single breath-hold CINE imaging with combined simultaneous multislice and region-optimized virtual coils. Kim D, Coll-Font J, Lobos RA, Stäb D, Pang J, Foster A, Garrett T, Bi X, Speier P, Haldar JP, Nguyen C. Magn Reson Med. 2023 Jul;90(1):222-230. PMID: 36864561.
Application of artificial intelligence in the diagnosis of sleep apnea. Bazoukis G, Bollepalli SC, Chung CT, Li X, Tse G, Bartley BL, Batool-Anwar S, Quan SF, Armoundas AA. J Clin Sleep Med. 2023 Jul 1;19(7):1337-1363. PMID: 36856067. Review.
Multiple Prior Live Births Are Associated With Cardiac Remodeling and Heart Failure Risk in Women. Sarma AA, Paniagua SM, Lau ES, Wang D, Liu EE, Larson MG, Hamburg NM, Mitchell GF, Kizer J, Psaty BM, Allen NB, Lely AT, Gansevoort RT, Rosenberg E, Mukamal K, Benjamin EJ, Vasan RS, Cheng S, Levy D, Boer RA, Gottdiener JS, Shah SJ, Ho JE. J Card Fail. 2023 Jul;29(7):1032-1042. PMID: 36638956.
Beyond cardiomyocytes: Cellular diversity in the heart’s response to exercise. Trager LE, Lyons M, Kuznetsov A, Sheffield C, Roh K, Freeman R, Rhee J, Guseh JS, Li H, Rosenzweig A. J Sport Health Sci. 2023 Jul;12(4):423-437. PMID: 36549585. Review.
Screening for undiagnosed atrial fibrillation using a single-lead electrocardiogram at primary care visits: patient uptake and practitioner perspectives from the VITAL-AF trial. Atlas SJ, Ashburner JM, Chang Y, Borowsky LH, Ellinor PT, McManus DD, Lubitz SA, Singer DE. BMC Prim Care. 2023 Jun 30;24(1):135. PMID: 37391738. Clinical Trial.
Integrative metabolomics differentiate coronary artery disease, peripheral artery disease, and venous thromboembolism risks. Lee J, Gilliland T, Koyama S, Nakao T, Dron J, Lannery K, Wong M, Peloso GM, Hornsby W, Natarajan P. medRxiv [Preprint]. 2023 Jun 27:2023.06.21.23291103. PMID: 37425786.
Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study. Wang Y, Selvaraj MS, Li X, Li Z, Holdcraft JA, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Cade BE, Carlson JC, Carson AP, Chen YI, Curran JE, de Vries PS, Dutcher SK, Ellinor PT, Floyd JS, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, Guo X, He J, Heard-Costa N, Hildalgo B, Hou L, Irvin MR, Joehanes R, Kaplan RC, Kardia SL, Kelly TN, Kim R, Kooperberg C, Kral BG, Levy D, Li C, Liu C, Lloyd-Jone D, Loos RJ, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Murabito JM, Naseri T, O’Connell JR, Palmer ND, Preuss MH, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Ruepena MS, Sheu WH, Smith JA, Smith A, Tiwari HK, Tsai MY, Viaud-Martinez KA, Wang Z, Yanek LR, Zhao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Rotter JI, Lin X, Natarajan P, Peloso GM. medRxiv [Preprint]. 2023 Jun 29:2023.06.28.23291966. PMID: 37425772.
Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation. Pluimer BR, Harrison DL, Boonyavairoje C, Prinssen EP, Rogers-Evans M, Peterson RT, Thyme SB, Nath AK. iScience. 2023 Jun 14;26(7):107099. PMID: 37416451.
IL-6 helps weave the inflammatory web during acute coronary syndromes. Nakao T, Libby P. J Clin Invest. 2023 Jun 1;133(11):e167670. PMID: 37259918.
Periprocedural Mortality in Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO Registry. Simsek B, Rempakos A, Kostantinis S, Karacsonyi J, Gorgulu S, Alaswad K, Choi JW, Jaffer FA, Doshi D, Poommipanit P, Aygul N, Krestyaninov O, Khelimskii D, Uretsky B, Davies R, Goktekin O, ElGuindy A, Jefferson BK, Patel TN, Patel M, Sheikh A, Karmpaliotis D, Potluri S, Al-Azizi K, Mastrodemos OC, Rangan BV, Allana SS, Sandoval Y, Burke MN, Brilakis ES. Circ Cardiovasc Interv. 2023 Jun;16(6):e012977. PMID: 37259859.
Transfer learning enables predictions in network biology. Theodoris CV, Xiao L, Chopra A, Chaffin MD, Al Sayed ZR, Hill MC, Mantineo H, Brydon EM, Zeng Z, Liu XS, Ellinor PT. Nature. 2023 Jun;618(7965):616-624. PMID: 37258680.
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation. Adlam D, Berrandou TE, Georges A, Nelson CP, Giannoulatou E, Henry J, Ma L, Blencowe M, Turley TN, Yang ML, Chopade S, Finan C, Braund PS, Sadeg-Sayoud I, Iismaa SE, Kosel ML, Zhou X, Hamby SE, Cheng J, Liu L, Tarr I, Muller DWM, d’Escamard V, King A, Brunham LR, Baranowska-Clarke AA, Debette S, Amouyel P, Olin JW, Patil S, Hesselson SE, Junday K, Kanoni S, Aragam KG, Butterworth AS; CARDIoGRAMPlusC4D; MEGASTROKE; International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group; Tweet MS, Gulati R, Combaret N; DISCO register; Kadian-Dodov D, Kalman JM, Fatkin D, Hingorani AD, Saw J, Webb TR, Hayes SN, Yang X, Ganesh SK, Olson TM, Kovacic JC, Graham RM, Samani NJ, Bouatia-Naji N. Nat Genet. 2023 Jun;55(6):964-972. PMID: 37248441.
Polygenic prediction of preeclampsia and gestational hypertension. Honigberg MC, Truong B, Khan RR, Xiao B, Bhatta L, Vy HMT, Guerrero RF, Schuermans A, Selvaraj MS, Patel AP, Koyama S, Cho SMJ, Vellarikkal SK, Trinder M, Urbut SM, Gray KJ, Brumpton BM, Patil S, Zöllner S, Antopia MC, Saxena R, Nadkarni GN, Do R, Yan Q, Pe’er I, Verma SS, Gupta RM, Haas DM, Martin HC, van Heel DA, Laisk T, Natarajan P. Nat Med. 2023 Jun;29(6):1540-1549. PMID: 37248299.
Pacing-induced cardiomyopathy after leadless pacemaker implant: It’s all about location, location, location. Pipilas D, Frankel DS, Khurshid S. J Cardiovasc Electrophysiol. 2023 Jun;34(6):1427-1430. PMID: 37245077.
Frequent questions and responses on the 2022 lipoprotein(a) consensus statement of the European Atherosclerosis Society. Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky ML, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard BG, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JK, Ray KK, Tokgözoğlu LS, Catapano AL. Atherosclerosis. 2023 Jun;374:107-120. PMID: 37188555. Review.
Determination of optimal tip position of peripherally inserted central catheters using electrocardiography: a retrospective study. Jung KT, Kelly L, Kuznetsov A, Sabouri AS, Lee K. Korean J Anesthesiol. 2023 Jun;76(3):242-251. PMID: 36550778.
Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk. Kojima S, Koyama S, Ka M, Saito Y, Parrish EH, Endo M, Takata S, Mizukoshi M, Hikino K, Takeda A, Gelinas AF, Heaton SM, Koide R, Kamada AJ, Noguchi M, Hamada M; Biobank Japan Project Consortium; Kamatani Y, Murakawa Y, Ishigaki K, Nakamura Y, Ito K, Terao C, Momozawa Y, Parrish NF. Nat Genet. 2023 Jun;55(6):939-951. PMID: 37169872.
Procedural Time and Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention. Rempakos A, Kostantinis S, Simsek B, Karacsonyi J, Choi JW, Poommipanit P, Khatri JJ, Jaber W, Rinfret S, Nicholson W, Gorgulu S, Jaffer FA, Chandwaney R, Ybarra LF, Bagur R, Alaswad K, Krestyaninov O, Khelimskii D, Karmpaliotis D, Uretsky BF, Soylu K, Yildirim U, Potluri S, Al-Azizi KM, Rangan BV, Mastrodemos OC, Allana S, Sandoval Y, Burke MN, Brilakis ES. Am J Cardiol. 2023 Jun 15;197:55-64. PMID: 37156067.
Obesity-induced inflammation exacerbates clonal hematopoiesis. Pasupuleti SK, Ramdas B, Burns SS, Palam LR, Kanumuri R, Kumar R, Pandhiri TR, Dave UP, Yellapu NK, Zhou X, Zhang C, Sandusky GE, Yu Z, Honigberg MC, Bick AG, Griffin GK, Niroula A, Ebert BL, Paczesny S, Natarajan P, Kapur R. J Clin Invest. 2023 Jun 1;133(11):e163968. PMID: 37071471
Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery. Yurista SR, Chen S, Eder RA, Garrett T, Butsch WS, Aminian A, Tang WHW, Farrar CT, Gee D, Abel ED, Das S, Nguyen CT. Obes Surg. 2023 Jun;33(6):1944-1948. PMID: 37058265.
Prediction of risk for myeloid malignancy in clonal hematopoiesis. Weeks LD, Niroula A, Neuberg D, Wong W, Lindsley RC, Luskin M, Berliner N, Stone RM, DeAngelo DJ, Soiffer R, Uddin MM, Griffin G, Vlasschaert C, Gibson CJ, Jaiswal S, Bick AG, Malcovati L, Natarajan P, Ebert BL. NEJM Evid. 2023 May;2(5):10.1056/evidoa2200310. PMID: 37483562.
Exomap1 mouse: a transgenic model for in vivo studies of exosome biology. Fordjour FK, Abuelreich S, Hong X, Chatterjee E, Lallai V, Ng M, Saftics A, Deng F, Carnel-Amar N, Wakimoto H, Shimizu K, Bautista M, Phu TA, Vu NK, Geiger PC, Raffai RL, Fowler CD, Das S, Christenson LK, Jovanovic-Talisman T, Gould SJ. bioRxiv [Preprint]. 2023 May 29:2023.05.29.542707. PMID: 37398219.
An AAV capsid increases transduction of striatum and a ChAT promoter allows selective cholinergic neuron transduction. Santoscoy MC, Espinoza P, De La Cruz D, Mahamdeh M, Starr JR, Patel N, Maguire CA. Mol Ther Methods Clin Dev. 2023 May 9;29:532-540. PMID: 37359416.
Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes. Zekavat SM, Jorshery SD, Shweikh Y, Horn K, Rauscher FG, Sekimitsu S, Kayoma S, Ye Y, Raghu V, Zhao H, Ghassemi M, Elze T, Segrè AV, Wiggs JL, Scholz M, Priore LD, Wang JC, Natarajan P, Zebardast N. medRxiv [Preprint]. 2023 May 17:2023.05.16.23290063. PMID: 37292770.
Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy. Luciani M, Montalbano M, Troncone L, Bacchin C, Uchida K, Daniele G, Jacobs Wolf B, Butler HM, Kiel J, Berto S, Gensemer C, Moore K, Morningstar J, Diteepeng T, Albayram O, Abisambra JF, Norris RA, Di Salvo TG, Prosser B, Kayed R, Del Monte F. Eur Heart J. 2023 May 1;44(17):1560-1570. PMID: 37122097.
Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2. Giannetti F, Barbieri M, Shiti A, Casini S, Sager PT, Das S, Pradhananga S, Srinivasan D, Nimani S, Alerni N, Louradour J, Mura M, Gnecchi M, Brink P, Zehender M, Koren G, Zaza A, Crotti L, Wilde AAM, Schwartz PJ, Remme CA, Gepstein L, Sala L, Odening KE. Europace. 2023 May 19;25(5):euad094. PMID: 37099628.
Genetics of myocardial interstitial fibrosis in the human heart and association with disease. Nauffal V, Di Achille P, Klarqvist MDR, Cunningham JW, Hill MC, Pirruccello JP, Weng LC, Morrill VN, Choi SH, Khurshid S, Friedman SF, Nekoui M, Roselli C, Ng K, Philippakis AA, Batra P, Ellinor PT, Lubitz SA. Nat Genet. 2023 May;55(5):777-786. PMID: 37081215.
Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration. Rämö JT, Abner E, van Dijk EHC, Wang X, Brinks J, Nikopensius T, Nõukas M, Marjonen H, Silander K, Jukarainen S, Kiiskinen T, Choi SH, Kajanne R, Mehtonen J, Palta P, Lubitz SA, Kaarniranta K, Sobrin L, Kurki M, Yzer S, Ellinor PT, Esko T, Daly MJ, den Hollander AI, Palotie A, Turunen JA, Boon CJF, Rossin EJ; FinnGen Study; Estonian Biobank Research Team. JAMA Ophthalmol. 2023 May 1;141(5):449-457. PMID: 37079300.
The Use of Artificial Intelligence to Predict the Development of Atrial Fibrillation. Pipilas D, Friedman SF, Khurshid S. Curr Cardiol Rep. 2023 May;25(5):381-389. PMID: 37000332. Review.
Outcomes of Early Rhythm Control Therapy in Patients With Atrial Fibrillation and a High Comorbidity Burden in Large Real-World Cohorts. Dickow J, Kany S, Roth Cardoso V, Ellinor PT, Gkoutos GV, Van Houten HK, Kirchhof P, Metzner A, Noseworthy PA, Yao X, Rillig A. Circ Arrhythm Electrophysiol. 2023 May;16(5):e011585. PMID: 36942567
Multipolar Ablation Using Mapping Electrodes: A Novel Approach to Intramural Arrhythmia Substrates. Fernandes GC, Nguyen T, Creed E, Lee K, Jung K, Hack B, Hucker W, Hanley A. JACC Clin Electrophysiol. 2023 May;9(5):680-685. PMID: 36752474. Review.
Accelerated and quantitative three-dimensional molecular MRI using a generative adversarial network. Weigand-Whittier J, Sedykh M, Herz K, Coll-Font J, Foster AN, Gerstner ER, Nguyen C, Zaiss M, Farrar CT, Perlman O. Magn Reson Med. 2023 May;89(5):1901-1914. PMID: 36585915.
A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets. Vlasschaert C, Mack T, Heimlich JB, Niroula A, Uddin MM, Weinstock J, Sharber B, Silver AJ, Xu Y, Savona M, Gibson C, Lanktree MB, Rauh MJ, Ebert BL, Natarajan P, Jaiswal S, Bick AG. Blood. 2023 May 4;141(18):2214-2223. PMID: 36652671.
Plasma protein and venous thromboembolism: prospective cohort and mendelian randomisation analyses. Yuan S, Titova OE, Zhang K, Gou W, Schillemans T, Natarajan P, Chen J, Li X, Åkesson A, Bruzelius M, Klarin D, Damrauer SM, Larsson SC. Br J Haematol. 2023 May;201(4):783-792. PMID: 36734038.
Adjusting for common variant polygenic scores improves yield in rare variant association analyses. Jurgens SJ, Pirruccello JP, Choi SH, Morrill VN, Chaffin M, Lubitz SA, Lunetta KL, Ellinor PT. Nat Genet. 2023 Apr;55(4):544-548. PMID: 36959364.
Atrial Fibrillation in Patients With Cancer: A Persistent and Increasing Challenge. Suero-Abreu GA, Ellinor PT. JACC CardioOncol. 2023 Apr 18;5(2):230-232.PMID: 37144117.
The genetic determinants of recurrent somatic mutations in 43,693 blood genomes. Weinstock JS, Laurie CA, Broome JG, Taylor KD, Guo X, Shuldiner AR, O’Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Redline S, Cade BE, Gilliland FD, Chen Z, Gauderman WJ, Kumar R, Grammer L, Schleimer RP, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Weiss ST, Lasky-Su J, DeMeo DL, Palmer ND, Freedman BI, Bowden DW, Cho MH, Vasan RS, Johnson AD, Yanek LR, Becker LC, Kardia S, He J, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Manichaikul AW, Konkle BA, Johnsen JM, Wheeler MM, Custer BS, Duggirala R, Curran JE, Blangero J, Gui H, Xiao S, Williams LK, Meyers DA, Li X, Ortega V, McGarvey S, Gu CC, Chen YI, Lee WJ, Shoemaker MB, Darbar D, Roden D, Albert C, Kooperberg C, Desai P, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Mathias R, Natarajan P, Jaiswal S, Reiner AP, Bick AG; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Sci Adv. 2023 Apr 28;9(17):eabm4945. PMID: 37126548.
A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([¹⁸F]GE-180) PET/MRI. Kim SJW, Lupo JM, Chen Y, Pampaloni MH, VanBrocklin HF, Narvid J, Kim H, Seo Y. Front Med (Lausanne). 2023 Apr 5;10:1091463. PMID: 37089589.
Multimodal charting of molecular and functional cell states via in situ electro-sequencing. Li Q, Lin Z, Liu R, Tang X, Huang J, He Y, Sui X, Tian W, Shen H, Zhou H, Sheng H, Shi H, Xiao L, Wang X, Liu J. Cell. 2023 Apr 27;186(9):2002-2017.e21. PMID: 37080201.
Clonal haematopoiesis and risk of chronic liver disease. Wong WJ, Emdin C, Bick AG, Zekavat SM, Niroula A, Pirruccello JP, Dichtel L, Griffin G, Uddin MM, Gibson CJ, Kovalcik V, Lin AE, McConkey ME, Vromman A, Sellar RS, Kim PG, Agrawal M, Weinstock J, Long MT, Yu B, Banerjee R, Nicholls RC, Dennis A, Kelly M, Loh PR, McCarroll S, Boerwinkle E, Vasan RS, Jaiswal S, Johnson AD, Chung RT, Corey K, Levy D, Ballantyne C; NHLBI TOPMed Hematology Working Group; Ebert BL, Natarajan P. Nature. 2023 Apr;616(7958):747-754. PMID: 37046084.
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. Weinstock JS, Gopakumar J, Burugula BB, Uddin MM, Jahn N, Belk JA, Bouzid H, Daniel B, Miao Z, Ly N, Mack TM, Luna SE, Prothro KP, Mitchell SR, Laurie CA, Broome JG, Taylor KD, Guo X, Sinner MF, von Falkenhausen AS, Kääb S, Shuldiner AR, O’Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Hou L, Lloyd-Jones DM, Redline S, Cade BE, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Palmer ND, Freedman BI, Bowden DW, Cho MH, DeMeo DL, Vasan RS, Yanek LR, Becker LC, Kardia SLR, Peyser PA, He J, Rienstra M, Van der Harst P, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Cutler MJ, Knight S, Muhlestein JB, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Tracy RP, Konkle BA, Johnsen JM, Wheeler MM, Smith JG, Melander O, Nilsson PM, Custer BS, Duggirala R, Curran JE, Blangero J, McGarvey S, Williams LK, Xiao S, Yang M, Gu CC, Chen YI, Lee WJ, Marcus GM, Kane JP, Pullinger CR, Shoemaker MB, Darbar D, Roden DM, Albert C, Kooperberg C, Zhou Y, Manson JE, Desai P, Johnson AD, Mathias RA; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Blackwell TW, Abecasis GR, Smith AV, Kang HM, Satpathy AT, Natarajan P, Kitzman JO, Whitsel EA, Reiner AP, Bick AG, Jaiswal S. Nature. 2023 Apr;616(7958):755-763. PMID: 37046083.
Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease. Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Sencicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2214997120. PMID: 37043537.
Contrast-Enhanced Cardiac Magnetic Resonance Imaging With a Manganese-Based Alternative to Gadolinium for Tissue Characterization of Acute Myocardial Infarction. Bonner BP, Yurista SR, Coll-Font J, Chen S, Eder RA, Foster AN, Nguyen KD, Caravan P, Gale EM, Nguyen C. J Am Heart Assoc. 2023 Apr 18;12(8):e026923. PMID: 37042259.
Accounting for blood attenuation in intravascular near-infrared fluorescence-ultrasound imaging using a fluorophore-coated guidewire. Rauschendorfer P, Wissmeyer G, Jaffer FA, Gorpas D, Ntziachristos V. J Biomed Opt. 2023 Apr;28(4):046001. PMID: 37035030.
The Genetic Determinants of Aortic Distention. Pirruccello JP, Rämö JT, Choi SH, Chaffin MD, Kany S, Nekoui M, Chou EL, Jurgens SJ, Friedman SF, Juric D, Stone JR, Batra P, Ng K, Philippakis AA, Lindsay ME, Ellinor PT. J Am Coll Cardiol. 2023 Apr 11;81(14):1320-1335. PMID: 37019578.
Association of Initial and Longitudinal Changes in C-reactive Protein With the Risk of Cardiovascular Disease, Cancer, and Mortality. Suthahar N, Wang D, Aboumsallem JP, Shi C, de Wit S, Liu EE, Lau ES, Bakker SJL, Gansevoort RT, van der Vegt B, Jovani M, Kreger BE, Lee Splansky G, Benjamin EJ, Vasan RS, Larson MG, Levy D, Ho JE, de Boer RA. Mayo Clin Proc. 2023 Apr;98(4):549-558. PMID: 37019514.
FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells. Wong D, Auguste G, Lino Cardenas CL, Turner AW, Chen Y, Song Y, Ma L, Perry RN, Aherrahrou R, Kuppusamy M, Yang C, Mosquera JV, Dube CJ, Khan MD, Palmore M, Kalra J, Kavousi M, Peyser PA, Matic L, Hedin U, Manichaikul A, Sonkusare SK, Civelek M, Kovacic JC, Björkegren JLM, Malhotra R, Miller CL. Circ Res. 2023 Apr 28;132(9):1144-1161. PMID: 37017084.
Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling. Kurz FT, Aon MA, Schlemmer HP, Jende JME, O’Rourke B, Armoundas AA. Biophys J. 2023 Apr 18;122(8):1459-1469. PMID: 36905121.
Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention After a Previous Failed Attempt. Rempakos A, Kostantinis S, Simsek B, Karacsonyi J, Choi JW, Poommipanit P, Khatri JJ, Jaber W, Rinfret S, Nicholson W, Gorgulu S, Jaffer FA, Chandwaney R, Ybarra LF, Bagur R, Alaswad K, Krestyaninov O, Khelimskii D, Karmpaliotis D, Uretsky BF, Soylu K, Yildirim U, Potluri S, Rangan BV, Mastrodemos OC, Allana S, Sandoval Y, Burke NM, Brilakis ES. Am J Cardiol. 2023 Apr 15;193:61-69. PMID: 36871531.
Persistent Iron Deficiency and Dysregulated Hepcidin Levels After Durable Left Ventricular Assist Device Therapy. Ton VK, Drezek K, Boerboom S, Ostrom KF, Birchenough C, Camuso J, Logan T, Milley K, Anthony A, Thomas SS, Coglianese E, D’Alessandro DD, Malhotra R, Lewis GD. ASAIO J. 2023 Apr 1;69(4):e152-e154. PMID: 36084293.
Prevalence and Therapeutic Implications of Clonal Hematopoiesis of Indeterminate Potential in Young Patients With Stroke. Mayerhofer E, Strecker C, Becker H, Georgakis MK, Uddin MM, Hoffmann MM, Nadarajah N, Meggendorfer M, Haferlach T, Rosand J, Natarajan P, Anderson CD, Harloff A, Hoermann G. Stroke. 2023 Apr;54(4):938-946. PMID: 36789775.
Reply. Zekavat SM, Sekimitsu S, Doroodgar Jorshery S, Natarajan P, Rossin EJ, Del Priore L, Zebardast N, Wang JC. Ophthalmology. 2023 Apr;130(4):e15-e16. PMID: 36707304
Identification and Management of Atherosclerotic Cardiovascular Disease Risk in South Asian Populations in the U.S. Agarwala A, Satish P, Rifai MA, Mehta A, Cainzos-Achirica M, Shah NS, Kanaya AM, Sharma GV, Dixon DL, Blumenthal RS, Natarajan P, Nasir K, Virani SS, Patel J. JACC Adv. 2023 Mar;2(2):100258. PMID: 38089916.
Looking into the mirror: Pulmonary vein isolation in a patient with dextrocardia, complete situs inversus, and interrupted inferior vena cava. Khurshid S, Nguyen T, Yamada K, Hanley A. HeartRhythm Case Rep. 2023 Mar 29;9(6):396-400. PMID: 37361983.
Effects of Mavacamten on Measures of Cardiopulmonary Exercise Testing Beyond Peak Oxygen Consumption: A Secondary Analysis of the EXPLORER-HCM Randomized Trial. Wheeler MT, Olivotto I, Elliott PM, Saberi S, Owens AT, Maurer MS, Masri A, Sehnert AJ, Edelberg JM, Chen YM, Florea V, Malhotra R, Wang A, Oreziak A, Myers J. JAMA Cardiol. 2023 Mar 1;8(3):240-247. PMID: 36652223. PMC9857843.
Identification and Management of Atherosclerotic Cardiovascular Disease Risk in South Asian Populations in the U.S. Agarwala A, Satish P, Rifai MA, Mehta A, Cainzos-Achirica M, Shah NS, Kanaya AM, Sharma GV, Dixon DL, Blumenthal RS, Natarajan P, Nasir K, Virani SS, Patel J. JACC Adv. 2023 Mar;2(2):100258. PMID: 38089916.
Artificial intelligence-enabled classification of hypertrophic heart diseases using electrocardiograms. Haimovich JS, Diamant N, Khurshid S, Di Achille P, Reeder C, Friedman S, Singh P, Spurlock W, Ellinor PT, Philippakis A, Batra P, Ho JE, Lubitz SA. Cardiovasc Digit Health J. 2023 Mar 7;4(2):48-59. PMID: 37101945.
A Mouse Model of Atrial Fibrillation in Sepsis. Bapat A, Schloss MJ, Yamazoe M, Grune J, Hulsmans M, Milan DJ, Nahrendorf M, Ellinor PT. Circulation. 2023 Mar 28;147(13):1047-1049. PMID: 36972346.
How often is occult atrial fibrillation in cryptogenic stroke causal vs. incidental? A meta-analysis. Chaisinanunkul N, Khurshid S, Buck BH, Rabinstein AA, Anderson CD, Hill MD, Fugate JE, Saver JL. Front Neurol. 2023 Mar 14;14:1103664. PMID: 36998779.
Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass. Khurshid S, Lazarte J, Pirruccello JP, Weng LC, Choi SH, Hall AW, Wang X, Friedman SF, Nauffal V, Biddinger KJ, Aragam KG, Batra P, Ho JE, Philippakis AA, Ellinor PT, Lubitz SA. Nat Commun. 2023 Mar 21;14(1):1558. PMID: 36944631.
Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases. Truong B, Hull LE, Ruan Y, Huang QQ, Hornsby W, Martin H, van Heel DA, Wang Y, Martin AR, Lee SH, Natarajan P. medRxiv [Preprint]. 2023 Mar 23:2023.02.21.23286110. PMID: 36865265.
Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program. Small AM, Peloso GM, Linefsky J, Aragam J, Galloway A, Tanukonda V, Wang LC, Yu Z, Sunitha Selvaraj M, Farber-Eger EH, Baker MT, Setia-Verma S, Lee SSK, Preuss M, Ritchie MD, Damrauer SM, Rader DJ, Wells QS, Loos R, Lubitz SA, Thanassoulis G, Cho K, Wilson PWF; VA Million Veteran Program; Natarajan P, O’Donnell CJ. Circulation. 2023 Mar 21;147(12):942-955. PMID: 36802703.
Systolic Blood Pressure and Cardiovascular Risk: Straightening the Evidence. McCarthy CP, Natarajan P. Hypertension. 2023 Mar;80(3):577-579. PMID: 36791225.
Clonal Hematopoiesis and Risk of Incident Lung Cancer. Tian R, Wiley B, Liu J, Zong X, Truong B, Zhao S, Uddin MM, Niroula A, Miller CA, Mukherjee S, Heiden BT, Luo J, Puri V, Kozower BD, Walter MJ, Ding L, Link DC, Amos CI, Ebert BL, Govindan R, Natarajan P, Bolton KL, Cao Y. J Clin Oncol. 2023 Mar 1;41(7):1423-1433. PMID: 36480766.
Impact of lesion length on the outcomes of chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS-CTO registry. Rempakos A, Simsek B, Kostantinis S, Karacsonyi J, Choi JW, Poommipanit P, Khatri JJ, Jaber W, Rinfret S, Nicholson W, Gorgulu S, Jaffer FA, Chandwaney R, Koutouzis M, Tsiafoutis I, Alaswad K, Krestyaninov O, Khelimskii D, Karmpaliotis D, Uretsky BF, Patel MP, Mahmud E, Potluri S, Rangan BV, Mastrodemos OC, Allana S, Sandoval Y, Burke NM, Brilakis ES. Catheter Cardiovasc Interv. 2023 Mar;101(4):747-755. PMID: 36740236.
Siblings with profound connective tissue disease: First report of biallelic TGFBR1-related Loeys-Dietz syndrome. Starr LJ, Lindsay ME, Lino Cardenas CL, Yetman AT. Am J Med Genet A. 2023 Mar;191(3):786-793. PMID: 36584339.
A seed sequence variant in miR-145-5p causes multisystem smooth muscle dysfunction syndrome. Lino Cardenas CL, Briere LC, Sweetser DA, Lindsay ME, Musolino PL. J Clin Invest. 2023 Mar 1;133(5):e166497. PMID: 36649075.
Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity. Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E. Eur Heart J. 2023 Mar 7;44(10):885-898. PMID: 36660854.
Cardioprotective Effects of a Selective c-Jun N-terminal Kinase Inhibitor in a Rat Model of Myocardial Infarction. Plotnikov MB, Chernysheva GA, Smol’yakova VI, Aliev OI, Fomina TI, Sandrikina LA, Sukhodolo IV, Ivanova VV, Osipenko AN, Anfinogenova ND, Khlebnikov AI, Atochin DN, Schepetkin IA, Quinn MT. Biomedicines. 2023 Feb 27;11(3):714. PMID: 36979693.
SGK1 inhibition attenuated the action potential duration in patient- and genotype-specific re-engineered heart cells with congenital long QT syndrome. Kim M, Das S, Tester DJ, Pradhananga S, Hamrick SK, Gao X, Srinivasan D, Sager PT, Ackerman MJ. Heart Rhythm O2. 2023 Feb 16;4(4):268-274. PMID: 37124559.
The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism. Bressan E, Reed X, Bansal V, Hutchins E, Cobb MM, Webb MG, Alsop E, Grenn FP, Illarionova A, Savytska N, Violich I, Broeer S, Fernandes N, Sivakumar R, Beilina A, Billingsley KJ, Berghausen J, Pantazis CB, Pitz V, Patel D, Daida K, Meechoovet B, Reiman R, Courtright-Lim A, Logemann A, Antone J, Barch M, Kitchen R, Li Y, Dalgard CL; American Genome Center; Rizzu P, Hernandez DG, Hjelm BE, Nalls M, Gibbs JR, Finkbeiner S, Cookson MR, Van Keuren-Jensen K, Craig DW, Singleton AB, Heutink P, Blauwendraat C. Cell Genom. 2023 Feb 6;3(3):100261. PMID: 36950378.
Co-occurring pathogenic variants in 6q27 associated with dementia spectrum disorders in a Peruvian family. Alvarez KLF, Aguilar-Pineda JA, Ortiz-Manrique MM, Paredes-Calderon MF, Cardenas-Quispe BC, Vera-Lopez KJ, Goyzueta-Mamani LD, Chavez-Fumagalli MA, Davila-Del-Carpio G, Peralta-Mestas A, Musolino PL, Lino Cardenas CL. Front Mol Neurosci. 2023 Feb 16;16:1104585. PMID: 36873109.
Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions. Obi AT, Sharma SB, Elfline MA, Luke CE, Dowling AR, Cai Q, Kimball AS, Hollinstat M, Stanger L, Moore BB, Jaffer FA, Henke PK. Sci Rep. 2023 Feb 24;13(1):3253. PMID: 36828892.
Soft robotic patient-specific hydrodynamic model of aortic stenosis and ventricular remodeling. Rosalia L, Ozturk C, Goswami D, Bonnemain J, Wang SX, Bonner B, Weaver JC, Puri R, Kapadia S, Nguyen CT, Roche ET. Sci Robot. 2023 Feb 22;8(75):eade2184. PMID: 36812335.
Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure. Simonson B, Chaffin M, Hill MC, Atwa O, Guedira Y, Bhasin H, Hall AW, Hayat S, Baumgart S, Bedi KC Jr, Margulies KB, Klattenhoff CA, Ellinor PT. Cell Rep. 2023 Feb 28;42(2):112086. PMID: 36790929.
Prevalence and Incidence of Atrial Fibrillation Among Older Primary Care Patients. Khurshid S, Ashburner JM, Ellinor PT, McManus DD, Atlas SJ, Singer DE, Lubitz SA. JAMA Netw Open. 2023 Feb 1;6(2):e2255838. PMID: 36780164.
Use of Mechanical Circulatory Support in Chronic Total Occlusion Percutaneous Coronary Intervention. Karacsonyi J, Deffenbacher K, Benzuly KH, Flaherty JD, Alaswad K, Basir M, Megaly MS, Jaffer F, Doshi D, Poommipanit P, Khatri J, Patel M, Riley R, Sheikh A, Wollmuth JR, Korngold E, Uretsky BF, Yeh RW, Chandwaney RH, Elguindy AM, Tammam K, AbiRafeh N, Schmidt CW, Okeson B, Kostantinis S, Simsek B, Rangan BV, Brilakis ES, Schimmel DR. Am J Cardiol. 2023 Feb 15;189:76-85. PMID: 36512989.
Association of Depression and Poor Mental Health With Cardiovascular Disease and Suboptimal Cardiovascular Health Among Young Adults in the United States. Kwapong YA, Boakye E, Khan SS, Honigberg MC, Martin SS, Oyeka CP, Hays AG, Natarajan P, Mamas MA, Blumenthal RS, Blaha MJ, Sharma G. J Am Heart Assoc. 2023 Feb 7;12(3):e028332. PMID: 36688365.
Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases. Li G, Chen T, Dahlman J, Eniola-Adefeso L, Ghiran IC, Kurre P, Lam WA, Lang JK, Marbán E, Martín P, Momma S, Moos M, Nelson DJ, Raffai RL, Ren X, Sluijter JPG, Stott SL, Vunjak-Novakovic G, Walker ND, Wang Z, Witwer KW, Yang PC, Lundberg MS, Ochocinska MJ, Wong R, Zhou G, Chan SY, Das S, Sundd P. J Extracell Vesicles. 2023 Feb;12(2):e12305. PMID: 36775986. Review.
Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention. Marston NA, Pirruccello JP, Melloni GEM, Koyama S, Kamanu FK, Weng LC, Roselli C, Kamatani Y, Komuro I, Aragam KG, Butterworth AS, Ito K, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT. JAMA Cardiol. 2023 Feb 1;8(2):130-137. PMID: 36576811.
A polygenic score for reduced kidney function and adverse outcomes in a cohort with chronic kidney disease. Steinbrenner I, Yu Z, Jin J, Schultheiss UT, Kotsis F, Grams ME, Coresh J, Wuttke M; GCKD Investigators; Kronenberg F, Eckardt KU, Chatterjee N, Sekula P, Köttgen A. Kidney Int. 2023 Feb;103(2):421-424. PMID: 36481179.
Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic Pathways, Inflammation, and Atherosclerosis. Liu H, Hallauer Hastings M, Kitchen R, Xiao C, Baldovino Guerra JR, Kuznetsov A, Rosenzweig A. Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):330-349. PMID: 36453275.
Sutton NR, Malhotra R, St Hilaire C, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y. Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification. Arterioscler Thromb Vasc Biol. 2023 Jan;43(1):15-29. PMID: 36412195. PMC9793888.
Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection. Liu A, Genovese G, Zhao Y, Pirinen M, Zekavat MM, Kentistou K, Yang Z, Yu K, Vlasschaert C, Liu X, Brown DW, Hudjashov G, Gorman B, Dennis J, Zhou W, Momozawa Y, Pyarajan S, Tuzov V, Pajuste FD, Aavikko M, Sipilä TP, Ghazal A, Huang WY, Freedman N, Song L, Gardner EJ, Sankaran VG, Palotie A, Ollila HM, Tukiainen T, Chanock SJ, Mägi R, Natarajan P, Daly MJ, Bick A, McCarroll SA, Terao C, Loh PR, Ganna A, Perry JRB, Machiela MJ. medRxiv [Preprint]. 2023 Jan 31:2023.01.28.23285140. PMID: 36778285.
Patient-Reported and Clinical Outcomes Among Patients With Calciphylaxis. Wen W, Krinsky S, Kroshinsky D, Durant O, He J, Seethapathy R, Hillien SAS, Mengesha B, Malhotra R, Chitalia V, Nazarian RM, Goverman J, Lyons KS, Nigwekar SU. Mayo Clin Proc Innov Qual Outcomes. 2023 Jan 24;7(1):81-92. PMID: 36712824.
Predicting Arterial Thrombotic Events Following Peripheral Revascularization Using Objective Viscoelastic Data. Majumdar M, Hall RP, Feldman Z, Goudot G, Sumetsky N, Jessula S, Kirshkaln A, Bellomo T, Chang D, Cardenas J, Patell R, Eagleton M, Dua A. J Am Heart Assoc. 2023 Jan 3;12(1):e027790. PMID: 36565191.
Extracellular Non-Coding RNAs in Cardiovascular Diseases. Jiapaer Z, Li C, Yang X, Sun L, Chatterjee E, Zhang L, Lei J, Li G. Pharmaceutics. 2023 Jan 3;15(1):155. PMID: 36678784. Review.
Photobiomodulation and nitric oxide signaling. Kashiwagi S, Morita A, Yokomizo S, Ogawa E, Komai E, Huang PL, Bragin DE, Atochin DN. Nitric Oxide. 2023 Jan 1;130:58-68. PMID: 36462596. Review.
Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank. Vlasschaert C, Heimlich JB, Rauh MJ, Natarajan P, Bick AG. Circulation. 2023 Jan 24;147(4):358-360. PMID: 36689568.
Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies. Li X, Quick C, Zhou H, Gaynor SM, Liu Y, Chen H, Selvaraj MS, Sun R, Dey R, Arnett DK, Bielak LF, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Correa A, Cupples LA, Curran JE, de Vries PS, Duggirala R, Freedman BI, Göring HHH, Guo X, Haessler J, Kalyani RR, Kooperberg C, Kral BG, Lange LA, Manichaikul A, Martin LW, McGarvey ST, Mitchell BD, Montasser ME, Morrison AC, Naseri T, O’Connell JR, Palmer ND, Peyser PA, Psaty BM, Raffield LM, Redline S, Reiner AP, Reupena MS, Rice KM, Rich SS, Sitlani CM, Smith JA, Taylor KD, Vasan RS, Willer CJ, Wilson JG, Yanek LR, Zhao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lipids Working Group; Rotter JI, Natarajan P, Peloso GM, Li Z, Lin X. Nat Genet. 2023 Jan;55(1):154-164. PMID: 36564505.
Polygenic risk scores for prediction of atrial fibrillation. Kavousi M, Ellinor PT. Neth Heart J. 2023 Jan;31(1):1-2. PMID: 36538263.
Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry. Djenoune L, Mahamdeh M, Truong TV, Nguyen CT, Fraser SE, Brueckner M, Howard J, Yuan S. Science. 2023 Jan 6;379(6627):71-78. PMID: 36603098.
TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease. Zekavat SM, Viana-Huete V, Matesanz N, Jorshery SD, Zuriaga MA, Uddin MM, Trinder M, Paruchuri K, Zorita V, Ferrer-Pérez A, Amorós-Pérez M, Kunderfranco P, Carriero R, Greco CM, Aroca-Crevillen A, Hidalgo A, Damrauer SM, Ballantyne CM, Niroula A, Gibson CJ, Pirruccello J, Griffin G, Ebert BL, Libby P, Fuster V, Zhao H, Ghassemi M, Natarajan P, Bick AG, Fuster JJ, Klarin D. Nat Cardiovasc Res. 2023 Jan 16;2:144-158. PMID: 36949957.
Therapeutics of Extracellular Vesicles in Cardiocerebrovascular and Metabolic Diseases. Hou Z, Lin Y, Yang X, Chen J, Li G. Adv Exp Med Biol. 2023;1418:187-205. PMID: 37603281.

2022

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M, Hindy G, Zhou W, Grace C, Roselli C, Marston NA, Kamanu FK, Surakka I, Venegas LM, Sherliker P, Koyama S, Ishigaki K, Åsvold BO, Brown MR, Brumpton B, de Vries PS, Giannakopoulou O, Giardoglou P, Gudbjartsson DF, Güldener U, Haider SMI, Helgadottir A, Ibrahim M, Kastrati A, Kessler T, Kyriakou T, Konopka T, Li L, Ma L, Meitinger T, Mucha S, Munz M, Murgia F, Nielsen JB, Nöthen MM, Pang S, Reinberger T, Schnitzler G, Smedley D, Thorleifsson G, von Scheidt M, Ulirsch JC; Biobank Japan; EPIC-CVD; Arnar DO, Burtt NP, Costanzo MC, Flannick J, Ito K, Jang DK, Kamatani Y, Khera AV, Komuro I, Kullo IJ, Lotta LA, Nelson CP, Roberts R, Thorgeirsson G, Thorsteinsdottir U, Webb TR, Baras A, Björkegren JLM, Boerwinkle E, Dedoussis G, Holm H, Hveem K, Melander O, Morrison AC, Orho-Melander M, Rallidis LS, Ruusalepp A, Sabatine MS, Stefansson K, Zalloua P, Ellinor PT, Farrall M, Danesh J, Ruff CT, Finucane HK, Hopewell JC, Clarke R, Gupta RM, Erdmann J, Samani NJ, Schunkert H, Watkins H, Willer CJ, Deloukas P, Kathiresan S, Butterworth AS; CARDIoGRAMplusC4D Consortium. Nat Genet. 2022 Dec;54(12):1803-1815. PMID: 36474045
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, et al. Genome Biol. 2022 Dec 27;23(1):268. PMID: 36575460.
Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults. Snel GJH, Slart RHJA, Velthuis BK, van den Boomen M, Nguyen CT, Sosnovik DE, van Deursen VM, Dierckx RAJO, Borra RJH, Prakken NHJ. PLoS One. 2022 Dec 1;17(12):e0278308. PMID: 36454872.
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, et al. Genome Biol. 2022 Dec 27;23(1):268. PMID: 36575460.
Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults. Snel GJH, Slart RHJA, Velthuis BK, van den Boomen M, Nguyen CT, Sosnovik DE, van Deursen VM, Dierckx RAJO, Borra RJH, Prakken NHJ. PLoS One. 2022 Dec 1;17(12):e0278308. PMID: 36454872.
Diminished muscle integrity in patients with fibrodysplasia ossificans progressiva assessed with at-home electrical impedance myography. Farid A, Golden E, Robicheau S, Hu A, Cheung K, Yu PB, Rutkove SB, Upadhyay J. Sci Rep. 2022 Dec 3;12(1):20908. PMID: 36463382.
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M, Hindy G, Zhou W, Grace C, Roselli C, Marston NA, Kamanu FK, Surakka I, Venegas LM, Sherliker P, Koyama S, Ishigaki K, Åsvold BO, Brown MR, Brumpton B, de Vries PS, Giannakopoulou O, Giardoglou P, Gudbjartsson DF, Güldener U, Haider SMI, Helgadottir A, Ibrahim M, Kastrati A, Kessler T, Kyriakou T, Konopka T, Li L, Ma L, Meitinger T, Mucha S, Munz M, Murgia F, Nielsen JB, Nöthen MM, Pang S, Reinberger T, Schnitzler G, Smedley D, Thorleifsson G, von Scheidt M, Ulirsch JC; Biobank Japan; EPIC-CVD; Arnar DO, Burtt NP, Costanzo MC, Flannick J, Ito K, Jang DK, Kamatani Y, Khera AV, Komuro I, Kullo IJ, Lotta LA, Nelson CP, Roberts R, Thorgeirsson G, Thorsteinsdottir U, Webb TR, Baras A, Björkegren JLM, Boerwinkle E, Dedoussis G, Holm H, Hveem K, Melander O, Morrison AC, Orho-Melander M, Rallidis LS, Ruusalepp A, Sabatine MS, Stefansson K, Zalloua P, Ellinor PT, Farrall M, Danesh J, Ruff CT, Finucane HK, Hopewell JC, Clarke R, Gupta RM, Erdmann J, Samani NJ, Schunkert H, Watkins H, Willer CJ, Deloukas P, Kathiresan S, Butterworth AS; CARDIoGRAMplusC4D Consortium. Nat Genet. 2022 Dec;54(12):1803-1815. PMID: 36474045.
Pocket CLARITY enables distortion-mitigated cardiac microstructural tissue characterization of large-scale specimens. Kim JJH, Parajuli S, Sinha A, Mahamdeh M, van den Boomen M, Coll-Font J, Chen LS, Fan Y, Eder RA, Phipps K, Yuan S, Nguyen C. Front Cardiovasc Med. 2022 Nov 14;9:1037500. PMID: 36451924.
Editorial: Cardiovascular engineering. Ozturk C, Schmid Daners M, Zhao X, Roche ET, Nguyen CT. Front Cardiovasc Med. 2022 Nov 21;9:1089794. PMID: 36479566.
Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals. Pirruccello JP, Lin H, Khurshid S, Nekoui M, Weng LC, Vasan RS, Isselbacher EM, Benjamin EJ, Lubitz SA, Lindsay ME, Ellinor PT. JAMA. 2022 Nov 15;328(19):1935-1944. PMID: 36378208.
Top2a promotes the development of social behavior via PRC2 and H3K27me3. Geng Y, Zhang T, Alonzo IG, Godar SC, Yates C, Pluimer BR, Harrison DL, Nath AK, Yeh JJ, Drummond IA, Bortolato M, Peterson RT. Sci Adv. 2022 Nov 25;8(47):eabm7069. PMID: 36417527.
Special Issue: Peripheral Factors and Neural Plasticity. van Praag H, Wrann CD. Brain Plast. 2022 Oct 21;8(1):1-3. PMID: 36448037.
Acquired lymphedema: Molecular contributors and future directions for developing intervention strategies. Nurlaila I, Roh K, Yeom CH, Kang H, Lee S. Front Pharmacol. 2022 Oct 25;13:873650. PMID: 36386144. Review.
Understudied factors in drug-coated balloon design and evaluation: A biophysical perspective. Shazly T, Torres WM, Secemsky EA, Chitalia VC, Jaffer FA, Kolachalama VB. Bioeng Transl Med. 2022 Jul 7;8(1):e10370. PMID: 36684110. Review.