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Pradeep Natarajan, MD, MMSc

Pradeep Natarajan, MD, MMSc

Director, Preventive Cardiology & Fireman Endowed Chair in Vascular Medicine
Massachusetts General Hospital
Associate Member
Broad Institute of Harvard and MIT

Associate Professor of Medicine
Harvard Medical School

Massachusetts General Hospital
Center for Systems Biology
Richard B. Simches Research Center
185 Cambridge Street, 3.184
Boston, MA 02114

Dr. Pradeep Natarajan is a preventive cardiologist, cardiovascular geneticist, and physician-scientist. He is the Director of Preventive Cardiology at Massachusetts General Hospital.

Coronary heart disease is a major cause of morbidity and morbidity worldwide. We use naturally-occuring human genetic variation, biomedical informatics, integrative genomics, and genotype-based deeper phenotyping to gain insights about cardiometabolic traits. We use the following approaches to use human genetic variation to understand human disease:

  1. identify causal factors that influence disease,
  2. test epidemiological associations for causal inference,
  3. disease risk prediction,
  4. therapeutic response prediction,
  5. discover and characterize the range of phenotypic consequences of putative therapeutic targets.

Such analyses are done through clinical recruitment, family-based studies, observational prospective cohorts, case-control cohorts, large-scale health-care associated biobanks, and randomized controlled clinical trials. We aim to leverage novel insights to improve preventive cardiovascular care.

Dr. Natarajan received his BA in Molecular & Cell Biology from the University of California, Berkeley (2004), MD from the University of California, San Francisco (2008), and MMSc in Biomedical Informatics from Harvard Medical School (2015). He completed internship and residency in Internal Medicine at Brigham & Women’s Hospital (2011) and cardiovascular diseases fellowship at Massachusetts General Hospital (2015). He completed post-doctral training in human genetics at the Massachusetts General Hospital and Broad Institute of Harvard & MIT.

Natarajan Lab

Research Areas
Vascular Biology and Metabolism

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