Director of Resynchronization and Advanced Cardiac Therapeutics Program
Associate Member, Broad Institute
Associate Professor of Medicine
Harvard Medical School
Massachusetts General Hospital
Cardiovascular Research Center
Simches Research Building
185 Cambridge Street, 3.190
Boston, MA 02114
The Das laboratory focuses on discovering and characterizing plasma RNAs and extracellular vesicles that may serve as biomarkers for disease phenotypes and processes associated with heart failure and left ventricular remodeling. As part of the NIH Extracellular RNA Communication Consortium we have developed new bioinformatics tools and techniques to measure extracellular RNAs and study their functional role in animal and cell culture models.
In addition we have worked on cellular processes such as autophagy that play a role in cardiac remodeling and may be regulated by extracellular vesicles and RNA. Finally, we are developing novel RNA-based therapies based on our human translational discoveries for treating cardiac remodeling and heart failure.
Cardiac Physiology and Disease